Imperial College London
Alternate

ProfessorElioRiboli

Faculty of Medicine, School of Public Health

Chair in Cancer Epidemiology and Prevention
 
 
 
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Contact

 

e.riboli Website CV

 
 
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Assistant

 

Ms Julieta Dourado +44 (0)20 7594 3426

 
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Location

 

152Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Papadimitriou:2021:10.1002/ijc.33246,
author = {Papadimitriou, N and Dimou, N and Gill, D and Tzoulaki, I and Murphy, N and Riboli, E and Lewis, SJ and Martin, RM and Gunter, MJ and Tsilidis, KK},
doi = {10.1002/ijc.33246},
journal = {International Journal of Cancer},
pages = {646--653},
title = {Genetically predicted circulating concentrations of micro-nutrients and risk of breast cancer: A Mendelian randomization study},
url = {http://dx.doi.org/10.1002/ijc.33246},
volume = {148},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The epidemiological literature reports inconsistent associations between consumption or circulating concentrations of micro-nutrients and breast cancer risk. We investigated associations between genetically predicted concentrations of 11 micro-nutrients (beta-carotene, calcium, copper, folate, iron, magnesium, phosphorus, selenium, vitamin B6, vitamin B12 and zinc) and breast cancer risk using Mendelian randomization (MR). A two-sample MR study was conducted using 122,977 women with breast cancer and 105,974 controls from the Breast Cancer Association Consortium. MR analyses were conducted using the inverse variance weighted approach, and sensitivity analyses were conducted to assess the impact of potential violations of MR assumptions. One standard deviation (SD: 0.08 mmol/L) higher genetically predicted concentration of magnesium was associated with a 17% (odds ratio [OR]: 1.17, 95% confidence interval [CI]: 1.10 to 1.25, P-value=9.1 ×10-7 ) and 20% (OR: 1.20, 95% CI: 1.08 to 1.34, P-value=3.2×10-6 ) higher risk of overall and ER+ve breast cancer, respectively. An inverse association was observed for a SD (0.5 mg/dL) higher genetically predicted phosphorus concentration and ER-ve breast cancer (OR: 0.84, 95% CI: 0.72 to 0.98, P-value=0.03). There was little evidence that any other nutrient was associated with breast cancer. The results for magnesium were robust under all sensitivity analyses and survived correction for multiple comparisons. Higher circulating concentrations of magnesium and potentially phosphorus may affect breast cancer risk. Further work is required to replicate these findings and investigate underlying mechanisms.
AU  - Papadimitriou,N
AU  - Dimou,N
AU  - Gill,D
AU  - Tzoulaki,I
AU  - Murphy,N
AU  - Riboli,E
AU  - Lewis,SJ
AU  - Martin,RM
AU  - Gunter,MJ
AU  - Tsilidis,KK
DO  - 10.1002/ijc.33246
EP  - 653
PY  - 2021///
SN  - 0020-7136
SP  - 646
TI  - Genetically predicted circulating concentrations of micro-nutrients and risk of breast cancer: A Mendelian randomization study
T2  - International Journal of Cancer
UR  - http://dx.doi.org/10.1002/ijc.33246
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32761610
UR  - https://onlinelibrary.wiley.com/doi/10.1002/ijc.33246
UR  - http://hdl.handle.net/10044/1/81935
VL  - 148
ER  -
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