Imperial College London
Alternate

ProfessorElioRiboli

Faculty of Medicine, School of Public Health

Chair in Cancer Epidemiology and Prevention
 
 
 
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Contact

 

e.riboli Website CV

 
 
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Assistant

 

Ms Julieta Dourado +44 (0)20 7594 3426

 
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Location

 

152Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Aune:2020:10.1038/s41598-020-76306-9,
author = {Aune, D and Sen, A and Kobeissi, E and Hamer, M and Norat, T and Riboli, E},
doi = {10.1038/s41598-020-76306-9},
journal = {Scientific Reports},
pages = {1--10},
title = {Physical activity and the risk of abdominal aortic aneurysm: a systematic review and meta-analysis of prospective studies},
url = {http://dx.doi.org/10.1038/s41598-020-76306-9},
volume = {10},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The association between physical activity and risk of abdominal aortic aneurysm has been inconsistent with some studies reporting a reduced risk while others have found no association. We conducted a systematic review and meta-analysis of prospective studies to quantify the association. PubMed and Embase databases were searched up to 3 October 2020. Prospective studies were included if they reported adjusted relative risk (RR) estimates and 95% confidence intervals (CIs) of abdominal aortic aneurysm associated with physical activity. Summary RRs (95% CIs) were estimated using a random effects model. Nine prospective studies (2073 cases, 409732 participants) were included. The summary RR for high vs. low physical activity was 0.70 (95% CI: 0.56-0.87, I2=58%) and per 20 metabolic equivalent task (MET)-hours/week increase of activity was 0.84 (95% CI: 0.74-0.95, I2=59%, n=6). Although the test for nonlinearity was not significant (p=0.09) the association appeared to be stronger when increasing the physical activity level from 0 to around 20-25 MET-hours/week than at higher levels. The current meta-analysis suggest that higher physical activity may reduce the risk of abdominal aortic aneurysm, however, further studies are needed to clarify the dose-response relationship between different subtypes and intensities of activity and abdominal aortic aneurysm risk.
AU  - Aune,D
AU  - Sen,A
AU  - Kobeissi,E
AU  - Hamer,M
AU  - Norat,T
AU  - Riboli,E
DO  - 10.1038/s41598-020-76306-9
EP  - 10
PY  - 2020///
SN  - 2045-2322
SP  - 1
TI  - Physical activity and the risk of abdominal aortic aneurysm: a systematic review and meta-analysis of prospective studies
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-020-76306-9
UR  - https://www.nature.com/articles/s41598-020-76306-9
UR  - http://hdl.handle.net/10044/1/85075
VL  - 10
ER  -
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