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@article{Clasen:2021:ajcn/nqab045,
author = {Clasen, J and Heath, A and Van, Puyvelde H and Huybrechts, I and Young, Park J and Ferrari, P and Johansson, M and Scelo, G and Midttun, Ø and Magne, Ueland P and Dahm, C and Halkjær, J and Olsen, A and Johnson, T and Katzke, V and Schulze, M and Masala, G and Segrado, F and Santucci, de Magistris M and Sacerdote, C and Ocké, M and Luján-Barroso, L and Ching-López, A and Huerta, JM and Ardanaz, E and Amiano, P and Ericson, U and Manjer, J and Gylling, B and Johansson, I and Schmidt, J and Weiderpass, E and Riboli, E and Cross, A and Muller, D},
doi = {ajcn/nqab045},
journal = {American Journal of Clinical Nutrition},
pages = {338--347},
title = {A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study},
url = {http://dx.doi.org/10.1093/ajcn/nqab045},
volume = {114},
year = {2021}
}

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TY  - JOUR
AB  - BackgroundVitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5′-phosphate (PLP) is a commonly used measure of vitamin B6 status. Ratios of substrates indicating PLP coenzymatic function and metabolism may be useful complementary measures to further explore the role of vitamin B6 in health.ObjectivesWe explored the sensitivity of 5 outcomes, namely PLP concentration, homocysteine:cysteine (Hcy:Cys), cystathionine:cysteine (Cysta:Cys), the 3-hydroxykynurenine ratio (HKr), and the 4-pyridoxic acid ratio (PAr) to vitamin B6 intake as well as personal and lifestyle characteristics.MedthodsDietary intake and biomarker data were collected from participants from 3 nested case-control studies within the European Prospective Investigation into Cancer and Nutrition (EPIC). Bayesian regression models assessed the associations of the 5 biomarker outcomes with vitamin B6 intake and personal and lifestyle covariates. Analogous models examined the relations of Hcy:Cys, Cysta:Cys, and HKr with PLP.ResultsIn total, 4608 participants were included in the analyses. Vitamin B6 intake was most strongly associated with PLP, moderately associated with Hcy:Cys, Cysta:Cys, and HKr, and not associated with PAr (fold change in marker given a doubling of vitamin B6 intake: PLP 1.60 [95% credible interval (CrI): 1.50, 1.71]; Hcy:Cys 0.87 [95% CrI: 0.84, 0.90]; Cysta:Cys 0.89 [95% CrI: 0.84, 0.94]; HKr 0.88 [95% CrI: 0.85, 0.91]; PAr 1.00 [95% CrI: 0.95, 1.05]). PAr was most sensitive to age, and HKr was least sensitive to BMI and alcohol intake. Sex and menopause status were strongly associated with all 5 markers.ConclusionsWe found that 5 different markers, capturing different aspects of vitamin B6–related biological processes, varied in their associations with vitamin B6 intake and personal and lifestyle predictors.
AU  - Clasen,J
AU  - Heath,A
AU  - Van,Puyvelde H
AU  - Huybrechts,I
AU  - Young,Park J
AU  - Ferrari,P
AU  - Johansson,M
AU  - Scelo,G
AU  - Midttun,Ø
AU  - Magne,Ueland P
AU  - Dahm,C
AU  - Halkjær,J
AU  - Olsen,A
AU  - Johnson,T
AU  - Katzke,V
AU  - Schulze,M
AU  - Masala,G
AU  - Segrado,F
AU  - Santucci,de Magistris M
AU  - Sacerdote,C
AU  - Ocké,M
AU  - Luján-Barroso,L
AU  - Ching-López,A
AU  - Huerta,JM
AU  - Ardanaz,E
AU  - Amiano,P
AU  - Ericson,U
AU  - Manjer,J
AU  - Gylling,B
AU  - Johansson,I
AU  - Schmidt,J
AU  - Weiderpass,E
AU  - Riboli,E
AU  - Cross,A
AU  - Muller,D
DO  - ajcn/nqab045
EP  - 347
PY  - 2021///
SN  - 0002-9165
SP  - 338
TI  - A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
T2  - American Journal of Clinical Nutrition
UR  - http://dx.doi.org/10.1093/ajcn/nqab045
UR  - https://academic.oup.com/ajcn/article/114/1/338/6214586
UR  - http://hdl.handle.net/10044/1/87830
VL  - 114
ER  -

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