Imperial College London
Alternate

ProfessorElioRiboli

Faculty of Medicine, School of Public Health

Chair in Cancer Epidemiology and Prevention
 
 
 
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Contact

 

e.riboli Website CV

 
 
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Assistant

 

Ms Julieta Dourado +44 (0)20 7594 3426

 
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Location

 

152Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Papadimitriou:2022:10.1016/j.cgh.2021.04.028,
author = {Papadimitriou, N and Bouras, E and van, den Brandt PA and Muller, DC and Papadopoulou, A and Heath, AK and Critselis, E and Gunter, MJ and Vineis, P and Ferrari, P and Weiderpass, E and Boeing, H and Bastide, N and Merritt, MA and Lopez, DS and Bergmann, MM and Perez-Cornago, A and Schulze, M and Skeie, G and Srour, B and Eriksen, AK and Boden, S and Johansson, I and Nøst, TH and Lukic, M and Ricceri, F and Ericson, U and Huerta, JM and Dahm, CC and Agnoli, C and Amiano, PE and Tjønneland, A and Gurrea, AB and Bueno-de-Mesquita, B and Ardanaz, E and Berntsson, J and Sánchez, M-J and Tumino, R and Panico, S and Katzke, V and Jakszyn, P and Masala, G and Derksen, JWG and Quirós, JR and Severi, G and Cross, AJ and Riboli, E and Tzoulaki, I and Tsilidis, KK},
doi = {10.1016/j.cgh.2021.04.028},
journal = {Clinical Gastroenterology and Hepatology},
pages = {864--873.e13},
title = {A prospective diet-wide association study for risk of colorectal cancer in EPIC},
url = {http://dx.doi.org/10.1016/j.cgh.2021.04.028},
volume = {20},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND & AIMS: Evidence regarding the association of dietary exposures with colorectal cancer (CRC) risk is not consistent with a few exceptions. Therefore, we conducted a diet-wide association study (DWAS) in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate the associations between several dietary exposures with CRC risk. METHODS: The association of 92 food and nutrient intakes with CRC risk was assessed in 386,792 participants, 5,069 of whom developed incident CRC. Correction for multiple comparisons was performed using the false discovery rate, and emerging associations were examined in the Netherlands Cohort Study (NLCS). Multiplicative gene-nutrient interactions were also tested in EPIC based on known CRC-associated loci. RESULTS: In EPIC, alcohol, liquor/spirits, wine, beer/cider, soft drinks, and pork were positively associated with CRC, whereas milk, cheese, calcium, phosphorus, magnesium, potassium, riboflavin, vitamin B6, beta-carotene, fruit, fibre, non-white bread, banana, and total protein intakes were inversely associated. Of these 20 associations, 13 were replicated in NLCS, for which a meta-analysis was performed, namely alcohol (summary HR per 1 SD increment in intake: 1.07; 95%CI:1.04-1.09), liquor/spirits (1.04; 1.02-1.06), wine (1.04;1.02-1.07), beer/cider (1.06;1.04-1.08), milk (0.95;0.93-0.98), cheese (0.96;0.94-0.99), calcium (0.93;0.90-0.95), phosphorus (0.92;0.90-0.95), magnesium (0.95;0.92-0.98), potassium (0.96;0.94-0.99), riboflavin (0.94;0.92-0.97), beta-carotene (0.96;0.93-0.98), and total protein (0.94;0.92-0.97). None of the gene-nutrient interactions were significant after adjustment for multiple comparisons. CONCLUSIONS: Our findings confirm a positive association for alcohol and an inverse association for dairy products and calcium with CRC risk, and also suggest a lower risk at higher dietary intakes of phosphorus, magnesium, potassium, riboflavin, beta-carotene and total protein.
AU  - Papadimitriou,N
AU  - Bouras,E
AU  - van,den Brandt PA
AU  - Muller,DC
AU  - Papadopoulou,A
AU  - Heath,AK
AU  - Critselis,E
AU  - Gunter,MJ
AU  - Vineis,P
AU  - Ferrari,P
AU  - Weiderpass,E
AU  - Boeing,H
AU  - Bastide,N
AU  - Merritt,MA
AU  - Lopez,DS
AU  - Bergmann,MM
AU  - Perez-Cornago,A
AU  - Schulze,M
AU  - Skeie,G
AU  - Srour,B
AU  - Eriksen,AK
AU  - Boden,S
AU  - Johansson,I
AU  - Nøst,TH
AU  - Lukic,M
AU  - Ricceri,F
AU  - Ericson,U
AU  - Huerta,JM
AU  - Dahm,CC
AU  - Agnoli,C
AU  - Amiano,PE
AU  - Tjønneland,A
AU  - Gurrea,AB
AU  - Bueno-de-Mesquita,B
AU  - Ardanaz,E
AU  - Berntsson,J
AU  - Sánchez,M-J
AU  - Tumino,R
AU  - Panico,S
AU  - Katzke,V
AU  - Jakszyn,P
AU  - Masala,G
AU  - Derksen,JWG
AU  - Quirós,JR
AU  - Severi,G
AU  - Cross,AJ
AU  - Riboli,E
AU  - Tzoulaki,I
AU  - Tsilidis,KK
DO  - 10.1016/j.cgh.2021.04.028
EP  - 873
PY  - 2022///
SN  - 1542-3565
SP  - 864
TI  - A prospective diet-wide association study for risk of colorectal cancer in EPIC
T2  - Clinical Gastroenterology and Hepatology
UR  - http://dx.doi.org/10.1016/j.cgh.2021.04.028
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33901663
UR  - https://www.sciencedirect.com/science/article/pii/S1542356521004626?via%3Dihub
UR  - http://hdl.handle.net/10044/1/90218
VL  - 20
ER  -
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