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@article{Fortuin-de:2022:eurjpc/zwac055,
author = {Fortuin-de, Smidt MC and Sewe, MO and Lassale, C and Weiderpass, E and Andersson, J and Huerta, JM and Ekelund, U and Aleksandrova, K and Tong, TYN and Dahm, CC and Tjønneland, A and Kyrø, C and Steindorf, K and Schulze, MB and Katzke, V and Sacerdote, C and Agnoli, C and Masala, G and Tumino, R and Panico, S and Boer, JMA and Onland-Moret, NC and Wendel-Vos, GCW and van, der Schouw YT and Borch, KB and Agudo, A and Petrova, D and Chirlaque, M-D and Conchi, M-I and Amiano, P and Melander, O and Heath, AK and Aune, D and Forouhi, NG and Langenberg, C and Brage, S and Riboli, E and Wareham, NJ and Danesh, J and Butterworth, AS and Wennberg, P},
doi = {eurjpc/zwac055},
journal = {European Journal of Preventive Cardiology},
pages = {1618--1629},
title = {Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors: EPIC-CVD case-cohort study},
url = {http://dx.doi.org/10.1093/eurjpc/zwac055},
volume = {29},
year = {2022}
}

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TY  - JOUR
AB  - AimsThis study aimed to evaluate the association between physical activity and the incidence of coronary heart disease (CHD) in individuals with and without CHD risk factors.Methods and resultsEPIC-CVD is a case-cohort study of 29 333 participants that included 13 582 incident CHD cases and a randomly selected sub-cohort nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Self-reported physical activity was summarized using the Cambridge physical activity index (inactive, moderately inactive, moderately active, and active). Participants were categorized into sub-groups based on the presence or the absence of the following risk factors: obesity (body mass index ≥30kg/m2), hypercholesterolaemia (total cholesterol ≥6.2mmol/L), history of diabetes, hypertension (self-reported or ≥140/90 mmHg), and current smoking. Prentice-weighted Cox regression was used to assess the association between physical activity and incident CHD events (non-fatal and fatal).Compared to inactive participants without the respective CHD risk factor (referent), excess CHD risk was highest in physically inactive and lowest in moderately active participants with CHD risk factors. Corresponding excess CHD risk estimates amongst those with obesity were 47% [95% confidence interval (CI) 32–64%] and 21% (95%CI 2–44%), with hypercholesterolaemia were 80% (95%CI 55–108%) and 48% (95%CI 22–81%), with hypertension were 80% (95%CI 65–96%) and 49% (95%CI 28–74%), with diabetes were 142% (95%CI 63–260%), and 100% (95%CI 32–204%), and amongst smokers were 152% (95%CI 122–186%) and 109% (95%CI 74–150%).ConclusionsIn people with CHD risk factors, moderate physical activity, equivalent to 40mins of walking per day, attenuates but does not completely offset CHD risk.
AU  - Fortuin-de,Smidt MC
AU  - Sewe,MO
AU  - Lassale,C
AU  - Weiderpass,E
AU  - Andersson,J
AU  - Huerta,JM
AU  - Ekelund,U
AU  - Aleksandrova,K
AU  - Tong,TYN
AU  - Dahm,CC
AU  - Tjønneland,A
AU  - Kyrø,C
AU  - Steindorf,K
AU  - Schulze,MB
AU  - Katzke,V
AU  - Sacerdote,C
AU  - Agnoli,C
AU  - Masala,G
AU  - Tumino,R
AU  - Panico,S
AU  - Boer,JMA
AU  - Onland-Moret,NC
AU  - Wendel-Vos,GCW
AU  - van,der Schouw YT
AU  - Borch,KB
AU  - Agudo,A
AU  - Petrova,D
AU  - Chirlaque,M-D
AU  - Conchi,M-I
AU  - Amiano,P
AU  - Melander,O
AU  - Heath,AK
AU  - Aune,D
AU  - Forouhi,NG
AU  - Langenberg,C
AU  - Brage,S
AU  - Riboli,E
AU  - Wareham,NJ
AU  - Danesh,J
AU  - Butterworth,AS
AU  - Wennberg,P
DO  - eurjpc/zwac055
EP  - 1629
PY  - 2022///
SN  - 2047-4873
SP  - 1618
TI  - Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors: EPIC-CVD case-cohort study
T2  - European Journal of Preventive Cardiology
UR  - http://dx.doi.org/10.1093/eurjpc/zwac055
UR  - https://academic.oup.com/eurjpc/advance-article/doi/10.1093/eurjpc/zwac055/6566157
UR  - http://hdl.handle.net/10044/1/96481
VL  - 29
ER  -

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