Imperial College London
Alternate

ProfessorElioRiboli

Faculty of Medicine, School of Public Health

Chair in Cancer Epidemiology and Prevention
 
 
 
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Contact

 

e.riboli Website CV

 
 
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Assistant

 

Ms Julieta Dourado +44 (0)20 7594 3426

 
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Location

 

152Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Casalone:2022:10.3390/cancers15010125,
author = {Casalone, E and Birolo, G and Pardini, B and Allione, A and Russo, A and Catalano, C and Mencoboni, M and Ferrante, D and Magnani, C and Sculco, M and Dianzani, I and Grosso, F and Mirabelli, D and Filiberti, RA and Rena, O and Sacerdote, C and Rodriguez-Barranco, M and Smith-Byrne, K and Panico, S and Agnoli, C and Johnson, T and Kaaks, R and Tumino, R and Huerta, JM and Riboli, E and Heath, AK and Trobajo-Sanmartín, C and Schulze, MB and Saieva, C and Amiano, P and Agudo, A and Weiderpass, E and Vineis, P and Matullo, G},
doi = {10.3390/cancers15010125},
journal = {Cancers},
pages = {1--15},
title = {Serum extracellular vesicle-derived microRNAs as potential biomarkers for pleural mesothelioma in a European prospective study},
url = {http://dx.doi.org/10.3390/cancers15010125},
volume = {15},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Malignant pleural mesothelioma (MPM) is an aggressive cancer with a dismal prognosis. Early therapeutic interventions could improve patient outcomes. We aimed to identify a pattern of microRNAs (miRNAs) as potential early non-invasive markers of MPM. In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition cohort, we screened the whole miRNome in serum extracellular vesicles (EVs) of preclinical MPM cases. In a subgroup of 20 preclinical samples collected five years prior MPM diagnosis, we observed an upregulation of miR-11400 (fold change (FC) = 2.6, adjusted p-value = 0.01), miR-148a-3p (FC = 1.5, p-value = 0.001), and miR-409-3p (FC = 1.5, p-value = 0.04) relative to matched controls. The 3-miRNA panel showed a good classification capacity with an area under the receiver operating characteristic curve (AUC) of 0.81 (specificity = 0.75, sensitivity = 0.70). The diagnostic ability of the model was also evaluated in an independent retrospective cohort, yielding a higher predictive power (AUC = 0.86). A signature of EV miRNA can be detected up to five years before MPM; moreover, the identified miRNAs could provide functional insights into the molecular changes related to the late carcinogenic process, preceding MPM development.
AU  - Casalone,E
AU  - Birolo,G
AU  - Pardini,B
AU  - Allione,A
AU  - Russo,A
AU  - Catalano,C
AU  - Mencoboni,M
AU  - Ferrante,D
AU  - Magnani,C
AU  - Sculco,M
AU  - Dianzani,I
AU  - Grosso,F
AU  - Mirabelli,D
AU  - Filiberti,RA
AU  - Rena,O
AU  - Sacerdote,C
AU  - Rodriguez-Barranco,M
AU  - Smith-Byrne,K
AU  - Panico,S
AU  - Agnoli,C
AU  - Johnson,T
AU  - Kaaks,R
AU  - Tumino,R
AU  - Huerta,JM
AU  - Riboli,E
AU  - Heath,AK
AU  - Trobajo-Sanmartín,C
AU  - Schulze,MB
AU  - Saieva,C
AU  - Amiano,P
AU  - Agudo,A
AU  - Weiderpass,E
AU  - Vineis,P
AU  - Matullo,G
DO  - 10.3390/cancers15010125
EP  - 15
PY  - 2022///
SN  - 2072-6694
SP  - 1
TI  - Serum extracellular vesicle-derived microRNAs as potential biomarkers for pleural mesothelioma in a European prospective study
T2  - Cancers
UR  - http://dx.doi.org/10.3390/cancers15010125
UR  - https://www.mdpi.com/2072-6694/15/1/125
UR  - http://hdl.handle.net/10044/1/101462
VL  - 15
ER  -
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