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@article{Agudo:2021:10.1007/s10654-021-00772-2,
author = {Agudo, A and Cayssials, V and Bonet, C and Tjønneland, A and Overvad, K and Boutron-Ruault, M-C and Affret, A and Fagherazzi, G and Katzke, V and Schubel, R and Trichopoulou, A and Karakatsani, A and La, Vecchia C and Palli, D and Grioni, S and Tumino, R and Ricceri, F and Panico, S and Bueno-de-Mesquita, B and Peeters, PH and Weiderpass, E and Skeie, G and Nøst, TH and Lasheras, C and Rodríguez-Barranco, M and Amiano, P and Chirlaque, M-D and Ardanaz, E and Ohlsson, B and Dias, JA and Nilsson, LM and Myte, R and Khaw, K-T and Perez-Cornago, A and Gunter, M and Huybrechts, I and Cross, AJ and Tsilidis, K and Riboli, E and Jakszyn, P},
doi = {10.1007/s10654-021-00772-2},
journal = {American Journal of Clinical Nutrition},
pages = {953--964},
title = {Inflammatory potential of the diet & risk of gastric cancer in the European Investigation into Cancer & Nutrition},
url = {http://dx.doi.org/10.1007/s10654-021-00772-2},
volume = {36},
year = {2021}
}

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TY  - JOUR
AB  - The role of chronic inflammation on breast cancer (BC) risk remains unclear beyond as an underlying mechanism of obesity and physical activity. We aimed to evaluate the association between the inflammatory potential of the diet and risk of BC overall, according to menopausal status and tumour subtypes. Within the European Prospective Investigation into Cancer and Nutrition cohort, 318,686 women were followed for 14 years, among whom 13,246 incident BC cases were identified. The inflammatory potential of the diet was characterized by an inflammatory score of the diet (ISD). Multivariable Cox regression models were used to assess the potential effect of the ISD on BC risk by means of hazard ratios (HR) and 95% confidence intervals (CI). ISD was positively associated with BC risk. Each increase of one standard deviation (1-Sd) of the score increased by 4% the risk of BC (HR = 1.04; 95% CI 1.01–1.07). Women in the highest quintile of the ISD (indicating a most pro-inflammatory diet) had a 12% increase in risk compared with those in the lowest quintile (HR = 1.12; 95% CI 1.04–1.21) with a significant trend. The association was strongest among premenopausal women, with an 8% increased risk for 1-Sd increase in the score (HR = 1.08; 95% CI 1.01–1.14). The pattern of the association was quite homogeneous by BC subtypes based on hormone receptor status. There were no significant interactions between ISD and body mass index, physical activity, or alcohol consumption. Women consuming more pro-inflammatory diets as measured by ISD are at increased risk for BC, especially premenopausal women.
AU  - Agudo,A
AU  - Cayssials,V
AU  - Bonet,C
AU  - Tjønneland,A
AU  - Overvad,K
AU  - Boutron-Ruault,M-C
AU  - Affret,A
AU  - Fagherazzi,G
AU  - Katzke,V
AU  - Schubel,R
AU  - Trichopoulou,A
AU  - Karakatsani,A
AU  - La,Vecchia C
AU  - Palli,D
AU  - Grioni,S
AU  - Tumino,R
AU  - Ricceri,F
AU  - Panico,S
AU  - Bueno-de-Mesquita,B
AU  - Peeters,PH
AU  - Weiderpass,E
AU  - Skeie,G
AU  - Nøst,TH
AU  - Lasheras,C
AU  - Rodríguez-Barranco,M
AU  - Amiano,P
AU  - Chirlaque,M-D
AU  - Ardanaz,E
AU  - Ohlsson,B
AU  - Dias,JA
AU  - Nilsson,LM
AU  - Myte,R
AU  - Khaw,K-T
AU  - Perez-Cornago,A
AU  - Gunter,M
AU  - Huybrechts,I
AU  - Cross,AJ
AU  - Tsilidis,K
AU  - Riboli,E
AU  - Jakszyn,P
DO  - 10.1007/s10654-021-00772-2
EP  - 964
PY  - 2021///
SN  - 1938-3207
SP  - 953
TI  - Inflammatory potential of the diet & risk of gastric cancer in the European Investigation into Cancer & Nutrition
T2  - American Journal of Clinical Nutrition
UR  - http://dx.doi.org/10.1007/s10654-021-00772-2
UR  - https://link.springer.com/article/10.1007%2Fs10654-021-00772-2
UR  - http://hdl.handle.net/10044/1/56391
VL  - 36
ER  -

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