Imperial College London
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Dr Ellie Sherrard-Smith

Faculty of Medicine, School of Public Health

Advanced Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 3229e.sherrard-smith

 
 
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Location

 

G27Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sherrard-Smith:2018:10.7554/eLife.35213,
author = {Sherrard-Smith, E and Sala, KA and Betancourt, M and Upton, LM and Angrisano, F and Morin, MJ and Ghani, AC and Churcher, TS and Blagborough, AM},
doi = {10.7554/eLife.35213},
journal = {eLife},
title = {Synergy in anti-malarial pre-erythrocytic and transmission-blocking antibodies is achieved by reducing parasite density},
url = {http://dx.doi.org/10.7554/eLife.35213},
volume = {7},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Anti-malarial pre-erythrocytic vaccines (PEV) target transmission by inhibiting human infection but are currently partially protective. It has been posited, but never demonstrated, that co-administering transmission-blocking vaccines (TBV) would enhance malaria control. We hypothesized a mechanism that TBV could reduce parasite density in the mosquito salivary glands, thereby enhancing PEV efficacy. This was tested using a multigenerational population assay, passaging Plasmodium berghei to Anopheles stephensi mosquitoes. A combined efficacy of 90.8% (86.7–94.2%) was observed in the PEV +TBV antibody group, higher than the estimated efficacy of 83.3% (95% CrI 79.1–87.0%) if the two antibodies acted independently. Higher PEV efficacy at lower mosquito parasite loads was observed, comprising the first direct evidence that co-administering anti-sporozoite and anti-transmission interventions act synergistically, enhancing PEV efficacy across a range of TBV doses and transmission intensities. Combining partially effective vaccines of differing anti-parasitic classes is a pragmatic, powerful way to accelerate malaria elimination efforts.
AU  - Sherrard-Smith,E
AU  - Sala,KA
AU  - Betancourt,M
AU  - Upton,LM
AU  - Angrisano,F
AU  - Morin,MJ
AU  - Ghani,AC
AU  - Churcher,TS
AU  - Blagborough,AM
DO  - 10.7554/eLife.35213
PY  - 2018///
SN  - 2050-084X
TI  - Synergy in anti-malarial pre-erythrocytic and transmission-blocking antibodies is achieved by reducing parasite density
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.35213
UR  - http://hdl.handle.net/10044/1/60240
VL  - 7
ER  -
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