Imperial College London
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Dr Ellie Sherrard-Smith

Faculty of Medicine, School of Public Health

Advanced Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 3229e.sherrard-smith

 
 
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Location

 

G27Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Marti-Soler:2021:10.1101/2021.03.03.433723,
author = {Marti-Soler, H and Maquina, M and Opiyo, M and Alafo, C and Sherrard-Smith, E and Malheia, A and Cuamba, N and Sacoor, C and Rabinovich, R and Aide, P and Saúte, F and Paaijmans, K},
doi = {10.1101/2021.03.03.433723},
title = {Effect of wall type, delayed mortality and mosquito age on the residual efficacy of a clothianidin-based indoor residual spray formulation (SumiShield™ 50WG) in southern Mozambique},
url = {http://dx.doi.org/10.1101/2021.03.03.433723},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Indoor residual spraying (IRS) is one of the main malaria vector control strategies in Mozambique alongside the distribution of insecticide treated nets. As part of the national insecticide resistance management strategy, Mozambique introduced SumiShield™ 50WG, a third generation IRS product, in 2018. Its residual efficacy was assessed in southern Mozambique during the 2018-2019 malaria season.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Two different wall surfaces, cement and mud-plastered surfaces, daily mosquito mortality up to 120 hours post-exposure, and older mosquitoes (13-26d old) were included in standard WHO (World Health Organization) cone bioassay tests. Lethal times (LT) 90, LT50 and LT10 were estimated using Bayesian models.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Mortality 24h post exposure was consistently below 80%, the current WHO threshold value for effective IRS, in both young and old mosquitoes, regardless of wall surface type. Considering delayed mortality, residual efficacies (mosquito mortality equal or greater than 80%) ranged from 1 to ≥12 months, with the duration depending on mortality time post exposure, wall type and mosquito age. Looking at mortality 72h after exposure, residual efficacy was between 6 and 9 months, depending on wall type and mosquito age. Mortality of older mosquitoes was significantly higher on mud-surfaces compared to cemented-surfaces 24h post exposure, but this difference was not significant for the delayed mortalities. The LT<jats:sub>50</jats:sub> and LT<jats:sub>10</jats:sub> (i.e. 90% of the mosquitoes survive exposure to the insecticides) values were consistently higher for older mosquitoes using the 24h post-exposure observations and
AU  - Marti-Soler,H
AU  - Maquina,M
AU  - Opiyo,M
AU  - Alafo,C
AU  - Sherrard-Smith,E
AU  - Malheia,A
AU  - Cuamba,N
AU  - Sacoor,C
AU  - Rabinovich,R
AU  - Aide,P
AU  - Saúte,F
AU  - Paaijmans,K
DO  - 10.1101/2021.03.03.433723
PY  - 2021///
TI  - Effect of wall type, delayed mortality and mosquito age on the residual efficacy of a clothianidin-based indoor residual spray formulation (SumiShield™ 50WG) in southern Mozambique
UR  - http://dx.doi.org/10.1101/2021.03.03.433723
ER  -
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