Imperial College London

Dr Evangelos Triantafyllou

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Lecturer in Liver Immunology
 
 
 
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Contact

 

e.triantafyllou Website

 
 
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Location

 

10.N12ACommonwealth BuildingHammersmith Campus

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Summary

 

Summary

Biography:

Evangelos Triantafyllou is Group Leader and Lecturer in Liver Immunology (Section of Hepatology and Gastroenterology). He holds a BSc in Biology (University of Athens, 2011) and a MSc in Developmental Biology (University of Bath, 2012). He undertook his PhD in Liver Immunology (King’s College London, Institute of Liver Studies, 2017) investigating the mechanisms of immune-mediated injury in liver failure, having spent a part of his doctoral work at the University of Birmingham (Centre for Liver & Gastrointestinal Research, 2014-15). In 2017 he joined Imperial College for post-doctoral research on immune (dys-)regulation in acute and chronic liver injury with a special focus on monocyte and macrophage inflammatory and bactericidal functions. He has been awarded funding from the Rosetrees Trust (2017 and 2021), an Imperial College Research Fellowship (2018-2022) and a UKRI MRC New Investigator Research Grant (2023).


Liver Immunology Group (Commonwealth Building 10th floor, Hammersmith campus):

Our lab investigates the cellular, molecular, and metabolic crosstalk underlying immune dysregulation in acute (APAP-induced ALF) and chronic (fibrosis, MASLD) liver injury. To explore this, we study both human tissue samples and in vivo models of liver inflammation using flow cytometry, intravital imaging, spatial multiplex staining, and single-cell genomics. Our work aims to improve our immunological understanding of liver disease pathogenesis and to identify targets for developing new immune-modulatory therapeutic approaches. 

https://www.imperial.ac.uk/metabolism-digestion-reproduction/research/digestive-diseases/hepatology--gastroenterology/liver-immunology-group/

Human liver tissue multiplex staining

Current research:

- Immunomodulatory approaches (e.g., TLR) in liver disease

- Checkpoint pathway [PD-(L)1, TIGIT] immune dysregulation

- Immune cell crosstalk in checkpoint inhibitor-induced hepatitis

- Dysregulated immunometabolism in liver failure syndromes

- TAM (Tyro3, Axl, MerTK) receptors and myeloid cell biology 

- Microbiome-immune cell interactions in MASLD

Funding: 

UKRI Medical Research Council, Rosetrees Trust, Imperial College London, NIHR Imperial Biomedical Research Centre

Selected Publications

Journal Articles

Trovato FM, Zia R, Artru F, et al., 2023, Lysophosphatidylcholines modulate immunoregulatory checkpoints in peripheral monocytes and are associated with mortality in people with acute liver failure., Journal of Hepatology, Vol:78, ISSN:0168-8278, Pages:558-573

Singanayagam A, Triantafyllou E, 2021, Macrophages in Chronic Liver Failure: Diversity, Plasticity and Therapeutic Targeting, Frontiers in Immunology, Vol:12

Triantafyllou E, Gudd CLC, Mawhin M-A, et al., 2021, PD-1 blockade improves Kupffer cell bacterial clearance in acute liver injury, Journal of Clinical Investigation, Vol:131, ISSN:0021-9738

Triantafyllou E, Pop O, Possamai L, et al., 2017, MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure, Gut, Vol:67, ISSN:1468-3288, Pages:333-347

More Publications