Imperial College London
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Dr Evangelos Triantafyllou

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Lecturer in Liver Immunology
 
 
 
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Contact

 

e.triantafyllou Website

 
 
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Location

 

10.N12ACommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Brenig:2020:10.26508/lsa.201900465,
author = {Brenig, R and Pop, OT and Triantafyllou, E and Geng, A and Singanayagam, A and Perez-Shibayama, C and Besse, L and Cupovic, J and Kuenzler, P and Boldanova, T and Brand, S and Semela, D and Duong, FHT and Weston, CJ and Ludewig, B and Heim, MH and Wendon, J and Antoniades, CG and Bernsmeier, C},
doi = {10.26508/lsa.201900465},
journal = {Life Science Alliance},
pages = {1--16},
title = {Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis},
url = {http://dx.doi.org/10.26508/lsa.201900465},
volume = {3},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Infectious complications in patients with cirrhosis frequently initiate episodes of decompensation and substantially contribute to the high mortality. Mechanisms of the underlying immuneparesis remain underexplored. TAM receptors (TYRO3/AXL/MERTK) are important inhibitors of innate immune responses. To understand the pathophysiology of immuneparesis in cirrhosis, we detailed TAM receptor expression in relation to monocyte function and disease severity prior to the onset of acute decompensation. TNF-α/IL-6 responses to lipopolysaccharide were attenuated in monocytes from patients with cirrhosis (n = 96) compared with controls (n = 27) and decreased in parallel with disease severity. Concurrently, an AXL-expressing (AXL+) monocyte population expanded. AXL+ cells (CD14+CD16highHLA-DRhigh) were characterised by attenuated TNF-α/IL-6 responses and T cell activation but enhanced efferocytosis and preserved phagocytosis of Escherichia coli. Their expansion correlated with disease severity, complications, infection, and 1-yr mortality. AXL+ monocytes were generated in response to microbial products and efferocytosis in vitro. AXL kinase inhibition and down-regulation reversed attenuated monocyte inflammatory responses in cirrhosis ex vivo. AXL may thus serve as prognostic marker and deserves evaluation as immunotherapeutic target in cirrhosis.
AU  - Brenig,R
AU  - Pop,OT
AU  - Triantafyllou,E
AU  - Geng,A
AU  - Singanayagam,A
AU  - Perez-Shibayama,C
AU  - Besse,L
AU  - Cupovic,J
AU  - Kuenzler,P
AU  - Boldanova,T
AU  - Brand,S
AU  - Semela,D
AU  - Duong,FHT
AU  - Weston,CJ
AU  - Ludewig,B
AU  - Heim,MH
AU  - Wendon,J
AU  - Antoniades,CG
AU  - Bernsmeier,C
DO  - 10.26508/lsa.201900465
EP  - 16
PY  - 2020///
SN  - 2575-1077
SP  - 1
TI  - Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis
T2  - Life Science Alliance
UR  - http://dx.doi.org/10.26508/lsa.201900465
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000511446200004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.life-science-alliance.org/content/3/1/e201900465
UR  - http://hdl.handle.net/10044/1/83023
VL  - 3
ER  -
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