Publications
142 results found
Carruthers J, Bottle R, Laverty AA, et al., 2017, Nationwide trends in non-alcoholic steatohepatitis in patients with and without diabetes between 2004 and 2014 in England, Diabetes UK Annual Professional Conference, Publisher: Wiley, Pages: 67-67, ISSN: 1464-5491
Chang KC-M, Majeed A, Vamos EP, et al., 2017, The authors respond to "NHS Health Check: national evaluation findings and implications", Publisher: Canadian Medical Association
Pérez-Pevida B, Romero S, Silva C, et al., 2017, Non-alcoholic fatty liver disease and pancreatic beta cell function in non-diabetic patients, EASD, Pages: 1-608
Vamos EP, Lewis E, Junghans C, et al., 2016, Community-based pilot intervention to tackle childhood obesity: a whole-system approach, Public Health, Vol: 140, Pages: 109-118, ISSN: 0033-3506
Objectives: Go-Golborne is a pilot intervention to prevent childhood obesity in the Royal Borough of Kensington and Chelsea between 2014 and 2018. It is a multi-strategy approach targeting children aged 0-16 years and their families in all settings where children live, learn and play. This paper describes the methodology and the practical steps in the development of Go-Golborne. Study design: The programme uses a quasi-experimental design for the evaluation of changes in weight status using data from the extended National Child Measurement Programme across local schools. For specific behavioural change objectives, baseline self-reported lifestyle measures will be compared against annual follow-up data over the 3-year study period. Qualitative methods will be used to explore the perceptions of stakeholders and participants and organizational change.Methods: Go-Golborne aims to mobilize everyone in the community who has a role or interest in shaping the local environment, norms and behaviors across a range of sectors. A community network of local organisations has been established to co-design all programme activities. A Steering Group of Council officers supports programme implementation and environmental changes. The programme has identified six specific behavior change objectives representing the key areas of need in Golborne and all activities in the council and the community target these objectives during specific programme phases. Key components include community capacity building, community-wide social marketing, environment and policy change and evaluation.Results (Progress): The programme is currently at the beginning of its implementation phase with activities in the community and council targeting the first behavior change objective. Conclusions: The pilot aims to test the effectiveness of this approach to support behavior change and prevent unhealthy weight gain in children using multiple strategies. This programme will inform the development of an interve
Vamos EP, Pape UJ, Curcin V, et al., 2016, Effectiveness of the influenza vaccine in preventing admission to hospital and death in people with type 2 diabetes., Canadian Medical Association Journal, ISSN: 0008-4409
BACKGROUND: The health burden caused by seasonal influenza is substantial. We sought to examine the effectiveness of influenza vaccination against admission to hospital for acute cardiovascular and respiratory conditions and all-cause death in people with type 2 diabetes. METHODS: We conducted a retrospective cohort study using primary and secondary care data from the Clinical Practice Research Datalink in England, over a 7-year period between 2003/04 and 2009/10. We enrolled 124 503 adults with type 2 diabetes. Outcome measures included admission to hospital for acute myocardial infarction (MI), stroke, heart failure or pneumonia/influenza, and death. We fitted Poisson regression models for influenza and off-season periods to estimate incidence rate ratios (IRR) for cohorts who had and had not received the vaccine. We used estimates for the summer, when influenza activity is low, to adjust for residual confounding. RESULTS: Study participants contributed to 623 591 person-years of observation during the 7-year study period. Vaccine recipients were older and had more comorbid conditions compared with nonrecipients. After we adjusted for covariates and residual confounding, vaccination was associated with significantly lower admission rates for stroke (IRR 0.70, 95% confidence interval [CI] 0.53-0.91), heart failure (IRR 0.78, 95% CI 0.65-0.92) and pneumonia or influenza (IRR 0.85, 95% CI 0.74-0.99), as well as all-cause death (IRR 0.76, 95% CI 0.65-0.83), and a nonsignificant change for acute MI (IRR 0.81, 95% CI 0.62-1.04) during the influenza seasons. INTERPRETATION: In this cohort of patients with type 2 diabetes, influenza vaccination was associated with reductions in rates of admission to hospital for specific cardiovascular events. Efforts should be focused on improvements in vaccine uptake in this important target group as part of comprehensive secondary prevention.
CHANG C, LEE T, VAMOS E, et al., 2016, Impact of NHS Health Check on cardiovascular disease risk: difference-in-differences matching analysis, Canadian Medical Association Journal, ISSN: 1488-2329
Vamos EP, Pape UJ, Curcin V, et al., 2014, Influenza vaccine effectiveness against hospitalisation and death in people with Type 2 diabetes, Publisher: WILEY-BLACKWELL, Pages: 74-75, ISSN: 0742-3071
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- Citations: 1
Dalton A, Vamos E, Harris M, et al., 2014, Impact of universal coverage on hypertension management: a cross-national study in the United States and England, PLoS ONE, Vol: 9, ISSN: 1932-6203
Background: The Patient Protection and Affordable Care Act (ACA) galvanised debate in the United States (US) overuniversal health coverage. Comparison with countries providing universal coverage may illustrate whether the ACA canimprove health outcomes and reduce disparities. We aimed to compare quality and disparities in hypertensionmanagement by socio-economic position in the US and England, the latter of which has universal health care.Method: We used data from the Health and Retirement Survey in the US, and the English Longitudinal Study for Aging fromEngland, including non-Hispanic White respondents aged 50–64 years (US market-based v NHS) and .65 years (USMedicarev NHS) with diagnosed hypertension. We compared blood pressure control to clinical guideline (140/90 mmHg)and audit (150/90 mmHg) targets; mean systolic and diastolic blood pressure and antihypertensive prescribing, anddisparities in each by educational attainment, income and wealth, using regression models.Results: There were no significant differences in aggregate achievement of clinical targets aged 50 to 65 years (US marketbasedvs. NHS- 62.3% vs. 61.3% [p = 0.835]). There was, however, greater control in the US in patients aged 65 years and over(US Medicare vs. NHS- 53.5% vs. 58.2% [p = 0.043]). England had no significant socioeconomic disparity in blood pressurecontrol (60.9% vs. 63.5% [p = 0.588], high and low wealth aged $65 years). The US had socioeconomic differences in the 50–64 years group (71.7% vs. 55.2% [p = 0.003], high and low wealth); these were attenuated but not abolished in Medicarebeneficiaries.Conclusion: Moves towards universal health coverage in the US may reduce disparities in hypertension management. Thecurrent situation, providing universal coverage for residents aged 65 years and over, may not be sufficient for equality incare.
Hamilton FLH, Laverty AA, Vamos EP, et al., 2012, Effect of financial incentives on ethnic disparities in smoking cessation interventions in primary care: cross-sectional study, Journal of Public Health
Background Smoking cessation interventions are underprovided in primary care. Financial incentives may help address this. However, few studies in the UK have examined their impact on disparities in the delivery of smoking cessation interventions.Methods Cross-sectional study using 2007 data from 29 general practices in Wandsworth, London, UK. We used logistic regression to examine associations between disease group [cardiovascular disease (CVD), respiratory disease, depression or none of these diseases], ethnicity and smoking outcomes following the introduction of the Quality and Outcomes Framework in 2004.Results Significantly, more CVD patients had smoking status ascertained compared with those with respiratory disease (89 versus 72%), but both groups received similar levels of cessation advice (93 and 89%). Patients with depression or none of the diseases were less likely to have smoking status ascertained (60% for both groups) or to receive advice (80 and 75%). Smoking prevalence was high, especially for patients with depression (44%). White British patients had higher rates of smoking than most ethnic groups, but black Caribbean men with depression had the highest smoking prevalence (62%).Conclusions Smoking rates remain high, particularly for white British and black Caribbean patients. Extending financial incentives to include recording of ethnicity and rewarding quit rates may further improve smoking cessation outcomes in primary care.
Hassanien AA, Al-Shaikh F, Vamos EP, et al., 2012, Epidemiology of end-stage renal disease in the countries of the Gulf Cooperation Council: a systematic review., JRSM Short Reports, Vol: 3, Pages: 1-21, ISSN: 2042-5333
OBJECTIVES: To describe the epidemiology of end stage renal disease (ESRD). DESIGN: Mixed-methods systematic review. SETTING: The countries of the Gulf Cooperation Council (GCC) which consist of Saudi Arabia, the United Arab Emirates, Kuwait, Qatar, Bahrain, and Oman. PARTICIPANTS: Defined to have ESRD or patients on regular dialysis for a minimum dialysis period of at least three months. Since many outcomes were reviewed, studies that estimated the incidence and prevalence of ESRD as outcomes should not have defined the study population as ESRD population or patients on regular dialysis. Studies where the study population mainly comprised children or pregnant woman were excluded. MAIN OUTCOME MEASURES: The trends of the incidence, prevalence, and mortality rate of ESRD; also, causes of mortality, primary causes and co-morbid conditions associated with ESRD. RESULTS: 44 studies included in this review show that the incidence of ESRD has increased while the prevalence and mortality rate of ESRD in the GCC has not been reported sufficiently. The leading primary causes of ESRD recorded in the countries of the GCC is diabetes with the most prevalent co-morbid conditions being Hypertension and Hepatitis C Virus infection; the most common cause of death was cardiovascular disease and sepsis. CONCLUSIONS: This review highlights that the lack of national renal registries data is a critical issue in the countries of the GCC. The available data also do not provide an accurate and updated estimate for relevant outcomes. Additionally, considering the increasing burden of chronic kidney disease (CKD), these results stressed the needs and the importance of preventative strategies for leading causes of ESRD. Furthermore, more studies are needed to describe the epidemiology of ESRD and for assessing the overall quality of renal care.
Vamos EP, Millett C, Parsons M, et al., 2012, Nationwide study on trends in hospital admissions for major cardiovascular events and procedures among people with and without diabetes in England, 2004 to 2009, Diabetes Care, Vol: 15, Pages: 265-272, ISSN: 0149-5992
OBJECTIVEIt is unclear whether people with and without diabetes equally benefitted from reductions in cardiovascular disease (CVD). We aimed to compare recent trends in hospital admission rates for angina, acute myocardial infarction (AMI), stroke, percutaneous coronary intervention (PCI), and coronary artery bypass graft (CABG) among people with and without diabetes in England.RESEARCH DESIGN AND METHODSWe identified all patients aged >16 years with cardiovascular events in England between 2004–2005 and 2009–2010 using national hospital activity data. Diabetes- and nondiabetes-specific rates were calculated for each year. To test for time trend, we fitted Poisson regression models.RESULTSIn people with diabetes, admission rates for angina, AMI, and CABG decreased significantly by 5% (rate ratio 0.95 [95% CI 0.94–0.96]), 5% (0.95 [0.93–0.97]), and 3% (0.97 [0.95–0.98]) per year, respectively. Admission rates for stroke did not significantly change (0.99 [0.98–1.004]) but increased for PCI (1.01 [1.005–1.03]) in people with diabetes. People with and without diabetes experienced similar proportional changes for all outcomes, with no significant differences in trends between these groups. However, diabetes was associated with an ~3.5- to 5-fold risk of CVD events. In-hospital mortality rates declined for AMI and stroke, remained unchanged for CABG, and increased for PCI admissions in both groups.CONCLUSIONSThis national study suggests similar changes in admissions for CVD in people with and without diabetes. Aggressive risk reduction is needed to further reduce the high absolute and relative risk of CVD still present in people with diabetes.
Vamos E, Harris M, Millett C, et al., 2012, Association of Systolic and diastolic blood pressure levels and all-cause mortality in people with newly diagnosed Type 2 diabetes: a retrospective cohort study, British Medical Journal, Vol: BMJ 2012; 345
Polner K, Szeifert L, Vamos EP, et al., 2011, Psychosocial characteristics and self-reported functional status in patients on maintenance dialysis in Hungary, CLINICAL NEPHROLOGY, Vol: 76, Pages: 455-463, ISSN: 0301-0430
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- Citations: 4
Vamos EP, Millett C, Parsons M, et al., 2011, Trends in hospital admissions for major cardiovascular events and procedures among people with and without diabetes between 2004 and 2009 in England: a nationwide study, 47th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Publisher: SPRINGER, Pages: S28-S28, ISSN: 0012-186X
Vamos EP, Pape U, Bottle A, et al., 2011, Association of practice size and pay-for-performance with quality of diabetes management in primary care., CMAJ
Vamos EP, Pape U, Bottle A, et al., 2011, Association between practice size and quality of diabetes management in primary care., Diabetes UK Annual Professional Conference
Szentkiralyi A, Czira ME, Molnar MZ, et al., 2011, High risk of obstructive sleep apnea is a risk factor of death censored graft loss in kidney transplant recipients: An observational cohort study, SLEEP MEDICINE, Vol: 12, Pages: 267-273, ISSN: 1389-9457
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- Citations: 21
Alshamsan R, Majeed A, Vamos EP, et al., 2011, Ethnic Differences in Diabetes Management in Patients With and Without Comorbid Medical Conditions: A cross-sectional study, Diabetes Care
de Lusignan S, Nitsch D, Belsey J, et al., 2011, Disparities in testing for renal function in UK primary care: cross-sectional study, Family Practice
Vamos EP, Bottle A, Edmonds ME, et al., 2010, Changes in the incidence of lower extremity amputations in people with and without diabetes in England between 2004 and 2008, Diabetes Care, Vol: 33, Pages: 2592-2597, ISSN: 1935-5548
OBJECTIVE — To describe recent trends in the incidence of nontraumatic amputationsamong individuals with and without diabetes and estimate the relative risk of amputationsamong individuals with diabetes in England.RESEARCH DESIGN AND METHODS — We identified all patients aged 16 yearswho underwent any nontraumatic amputation in England between 2004 and 2008 using nationalhospital activity data from all National Health Service hospitals. Age- and sex-specificincidence rates were calculated using the total diabetes population in England every year. To testfor time trend, we fitted Poisson regression models.RESULTS — The absolute number of diabetes-related amputations increased by 14.7%, andthe incidence decreased by 9.1%, from 27.5 to 25.0 per 10,000 people with diabetes, during thestudy period (P 0.2 for both). The incidence of minor and major amputations did notsignificantly change (15.7–14.9 and 11.8–10.2 per 10,000 people with diabetes; P 0.66 andP 0.29, respectively). Poisson regression analysis showed no statistically significant change indiabetes-related amputation incidence over time (0.98 decrease per year [95% CI 0.93–1.02];P 0.12). Nondiabetes-related amputation incidence decreased from 13.6 to 11.9 per 100,000people without diabetes (0.97 decrease by year [0.93–1.00]; P 0.059). The relative risk of anindividual with diabetes undergoing a lower extremity amputation was 20.3 in 2004 and 21.2 in2008, compared with that of individuals without diabetes.CONCLUSIONS — This national study suggests that the overall population burden of amputationsincreased in people with diabetes at a time when the number and incidence of amputationsdecreased in the aging nondiabetic population.
Vamos EP, Bottle A, Majeed A, et al., 2010, Changes in the incidence of lower extremity amputations in people with and without diabetes in England between 2004 and 2008, 46th EASD Annual Meeting
Novak M, Molnar MZ, Szeifert L, et al., 2010, Depressive Symptoms and Mortality in Patients After Kidney Transplantation: A Prospective Prevalent Cohort Study, PSYCHOSOMATIC MEDICINE, Vol: 72, Pages: 527-534, ISSN: 0033-3174
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- Citations: 87
Torzsa P, Keszei A, Kalabay L, et al., 2010, Socio-demographic characteristics, health behaviour, co-morbidity and accidents in snorers: a population survey, Sleep Breath
Vamos EP, Csepanyi G, Molnar MZ, et al., 2010, Attitudes towards renal transplantation in patients on maintenance hemodialysis, Hypertonia & Nephrologia, Vol: 14, Pages: 43-50
Hamilton F, Bottle A, Vamos EP, et al., 2010, Impact of a pay for performance incentive scheme on age, sex and socio-economic inequalities in diabetes management in UK primary care, J Amb Care Med
Remport A, Keszei A, Vamos EP, et al., 2010, Association of pre-transplant dialysis duration with outcome in kidney transplanted recipients – a prevalent cohort study., Int Urol Nephrol
Vamos EP, Novak M, Mucsi I, 2009, Non-medical factors influencing access to renal transplantation, INTERNATIONAL UROLOGY AND NEPHROLOGY, Vol: 41, Pages: 607-616, ISSN: 0301-1623
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- Citations: 32
Vamos EP, Bottle A, Majeed A, et al., 2009, Trends in lower extremity amputations in people with and without diabetes in England, 1996-2005, 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Publisher: SPRINGER, Pages: S447-S447, ISSN: 0012-186X
Szentkiralyi A, Molnar MZ, Czira ME, et al., 2009, Association between Restless Legs Syndrome and Depression in Patients with Chronic Kidney Disease, J Psychosom Res, Vol: 67, Pages: 173-180
Mucsi I, Vamos EP, Keszei A, et al., 2009, Comorbid depression is associated with increased health care utilization and lost productivity in people with diabetes: a large nationally representative Hungarian population survey., Journal of Psychosomatic Research, XII Annual Meeting of the European Association for Consultation-Liason Psychiatry and Psychosomatics (EACLPP), Pages: 571-572, ISSN: 0022-3999
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