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@article{Misra:2021:10.1016/S2213-8587(21)00208-4,
author = {Misra, S and Barron, E and Vamos, E and Thomas, S and Dhatariya, K and Kar, P and Young, B and Khunti, K and Valabhji, J},
doi = {10.1016/S2213-8587(21)00208-4},
journal = {The Lancet Diabetes and Endocrinology},
title = {Temporal trends in emergency admissions for diabetic ketoacidosis in people with diabetes in England before and during the COVID-19 pandemic: a population-based study},
url = {http://dx.doi.org/10.1016/S2213-8587(21)00208-4},
year = {2021}
}

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TY  - JOUR
AB  - BACKGROUND: Diabetic ketoacidosis (DKA) has been reported to be increasing in frequency during the COVID-19 pandemic. We aimed to examine the rates of DKA hospital admissions and the patient demographics associated with DKA during the pandemic compared with in prepandemic years. METHODS: Using a comprehensive, multiethnic, national dataset, the Secondary Uses Service repository, we extracted all emergency hospital admissions in England coded with DKA from March 1 to June 30, 2020 (first wave of the pandemic), July 1 to Oct 31, 2020 (post-first wave), and Nov 1, 2020, to Feb 28, 2021 (second wave), and compared these with DKA admissions in the equivalent periods in 2017-20. We also examined baseline characteristics, mortality, and trends in patients who were admitted with DKA. FINDINGS: There were 8553 admissions coded with DKA during the first wave, 8729 during the post-first wave, and 10 235 during the second wave. Compared with preceding years, DKA admissions were 6% (95% CI 4-9; p<0·0001) higher in the first wave of the pandemic (from n=8048), 6% (3-8; p<0·0001) higher in the post-first wave (from n=8260), and 7% (4-9; p<0·0001) higher in the second wave (from n=9610). In the first wave, DKA admissions reduced by 19% (95% CI 16-21) in those with pre-existing type 1 diabetes (from n=4965 to n=4041), increased by 41% (35-47) in those with pre-existing type 2 diabetes (from n=2010 to n=2831), and increased by 57% (48-66) in those with newly diagnosed diabetes (from n=1072 to n=1681). Compared with prepandemic, type 2 diabetes DKA admissions were similarly common in older individuals and men but were higher in those of non-White ethnicities during the first wave. The increase in newly diagnosed DKA admissions occurred across all age groups and these were significantly increased in men and people of non-White ethnicities. In the post-first wave, DKA admissions did not return to the baseline level of previous years; DKA admissions w
AU  - Misra,S
AU  - Barron,E
AU  - Vamos,E
AU  - Thomas,S
AU  - Dhatariya,K
AU  - Kar,P
AU  - Young,B
AU  - Khunti,K
AU  - Valabhji,J
DO  - 10.1016/S2213-8587(21)00208-4
PY  - 2021///
SN  - 2213-8595
TI  - Temporal trends in emergency admissions for diabetic ketoacidosis in people with diabetes in England before and during the COVID-19 pandemic: a population-based study
T2  - The Lancet Diabetes and Endocrinology
UR  - http://dx.doi.org/10.1016/S2213-8587(21)00208-4
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34481558
ER  -

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