Imperial College London
Alternate

DrErikVolz

Faculty of Medicine, School of Public Health

Reader in Population Biology of Infectious Diseases
 
 
 
//

Contact

 

+44 (0)20 7594 1933e.volz Website

 
 
//

Location

 

UG10Norfolk PlaceSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Nascimento:2020:10.1016/j.epidem.2019.100376,
author = {Nascimento, FF and Baral, S and Geidelberg, L and Mukandavire, C and Schwartz, SR and Turpin, G and Turpin, N and Diouf, D and Diouf, NL and Coly, K and Kane, CT and Ndour, C and Vickerman, P and Boily, M-C and Volz, EM},
doi = {10.1016/j.epidem.2019.100376},
journal = {Epidemics: the journal of infectious disease dynamics},
pages = {1--11},
title = {Phylodynamic analysis of HIV-1 subtypes B, C and CRF 02_AG in Senegal},
url = {http://dx.doi.org/10.1016/j.epidem.2019.100376},
volume = {30},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Surveillance of HIV epidemics in key populations and in developing countries is often challenging due to sparse, incomplete, or low-quality data. Analysis of HIV sequence data can provide an alternative source of information about epidemic history, population structure, and transmission patterns. To understand HIV-1 dynamics and transmission patterns in Senegal, we carried out model-based phylodynamic analyses using the structured-coalescent approach using HIV-1 sequence data from three different subgroups: reproductive aged males and females from the adult Senegalese population and men who have sex with other men (MSM). We fitted these phylodynamic analyses to time-scaled phylogenetic trees individually for subtypes C and CRF 02_AG, and for the combined data for subtypes B, C and CRF 02_AG. In general, the combined analysis showed a decreasing proportion of effective number of infections among all reproductive aged adults relative to MSM. However, we observed a nearly time-invariant distribution for subtype CRF 02_AG and an increasing trend for subtype C on the proportion of effective number of infections. The population attributable fraction also differed between analyses: subtype CRF 02_AG showed little contribution from MSM, while for subtype C and combined analyses this contribution was much higher. Despite observed differences, results suggested that the combination of high assortativity among MSM and the unmet HIV prevention and treatment needs represent a significant component of the HIV epidemic in Senegal.
AU  - Nascimento,FF
AU  - Baral,S
AU  - Geidelberg,L
AU  - Mukandavire,C
AU  - Schwartz,SR
AU  - Turpin,G
AU  - Turpin,N
AU  - Diouf,D
AU  - Diouf,NL
AU  - Coly,K
AU  - Kane,CT
AU  - Ndour,C
AU  - Vickerman,P
AU  - Boily,M-C
AU  - Volz,EM
DO  - 10.1016/j.epidem.2019.100376
EP  - 11
PY  - 2020///
SN  - 1755-4365
SP  - 1
TI  - Phylodynamic analysis of HIV-1 subtypes B, C and CRF 02_AG in Senegal
T2  - Epidemics: the journal of infectious disease dynamics
UR  - http://dx.doi.org/10.1016/j.epidem.2019.100376
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000522664200010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S1755436519300660?via%3Dihub
UR  - http://hdl.handle.net/10044/1/83856
VL  - 30
ER  -
Download