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@article{Nyberg:2022:10.1016/S0140-6736(22)00462-7,
author = {Nyberg, T and Ferguson, NM and Nash, SG and Webster, HH and Flaxman, S and Andrews, N and Hinsley, W and Bernal, JL and Kall, M and Bhatt, S and Blomquist, P and Zaidi, A and Volz, E and Aziz, NA and Harman, K and Funk, S and Abbott, S and Hope, R and Charlett, A and Chand, M and Ghani, AC and Seaman, SR and Dabrera, G and De, Angelis D and Presanis, AM and Thelwall, S},
doi = {10.1016/S0140-6736(22)00462-7},
journal = {The Lancet},
pages = {1303--1312},
title = {Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study},
url = {http://dx.doi.org/10.1016/S0140-6736(22)00462-7},
volume = {399},
year = {2022}
}

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TY  - JOUR
AB  - BackgroundThe omicron variant (B.1.1.529) of SARS-CoV-2 has demonstrated partial vaccine escape and high transmissibility, with early studies indicating lower severity of infection than that of the delta variant (B.1.617.2). We aimed to better characterise omicron severity relative to delta by assessing the relative risk of hospital attendance, hospital admission, or death in a large national cohort.MethodsIndividual-level data on laboratory-confirmed COVID-19 cases resident in England between Nov 29, 2021, and Jan 9, 2022, were linked to routine datasets on vaccination status, hospital attendance and admission, and mortality. The relative risk of hospital attendance or admission within 14 days, or death within 28 days after confirmed infection, was estimated using proportional hazards regression. Analyses were stratified by test date, 10-year age band, ethnicity, residential region, and vaccination status, and were further adjusted for sex, index of multiple deprivation decile, evidence of a previous infection, and year of age within each age band. A secondary analysis estimated variant-specific and vaccine-specific vaccine effectiveness and the intrinsic relative severity of omicron infection compared with delta (ie, the relative risk in unvaccinated cases).FindingsThe adjusted hazard ratio (HR) of hospital attendance (not necessarily resulting in admission) with omicron compared with delta was 0·56 (95% CI 0·54–0·58); for hospital admission and death, HR estimates were 0·41 (0·39–0·43) and 0·31 (0·26–0·37), respectively. Omicron versus delta HR estimates varied with age for all endpoints examined. The adjusted HR for hospital admission was 1·10 (0·85–1·42) in those younger than 10 years, decreasing to 0·25 (0·21–0·30) in 60–69-year-olds, and then increasing to 0·47 (0·40–0·56) in those aged at leas
AU  - Nyberg,T
AU  - Ferguson,NM
AU  - Nash,SG
AU  - Webster,HH
AU  - Flaxman,S
AU  - Andrews,N
AU  - Hinsley,W
AU  - Bernal,JL
AU  - Kall,M
AU  - Bhatt,S
AU  - Blomquist,P
AU  - Zaidi,A
AU  - Volz,E
AU  - Aziz,NA
AU  - Harman,K
AU  - Funk,S
AU  - Abbott,S
AU  - Hope,R
AU  - Charlett,A
AU  - Chand,M
AU  - Ghani,AC
AU  - Seaman,SR
AU  - Dabrera,G
AU  - De,Angelis D
AU  - Presanis,AM
AU  - Thelwall,S
DO  - 10.1016/S0140-6736(22)00462-7
EP  - 1312
PY  - 2022///
SN  - 0140-6736
SP  - 1303
TI  - Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study
T2  - The Lancet
UR  - http://dx.doi.org/10.1016/S0140-6736(22)00462-7
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000812828300022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00462-7/fulltext
UR  - http://hdl.handle.net/10044/1/102179
VL  - 399
ER  -

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