I am the Waters Senior Lecturer in Molecular Spectroscopy in the Department of Surgery and Cancer. I joined Imperial College in 2006 after working as a postdoctoral researcher at the Scripps Research Institute in La Jolla, CA. At Imperial College, I was initially a postdoctoral researcher for the Consortium for Metabonomic Toxicology (COMET) group.
My research focuses primarily on the development and application of novel mass spectrometry (MS) based techniques for metabolic phenotyping and on the fusion of mass spectrometric methods with chemometric analysis, which is currently a significant bottleneck in the analysis pipeline. Broadly, my research at Imperial College has involved the development, optimisation and application of UPLC-MS methodologies for the analysis of biological samples, largely in the context of metabolic phenotyping: serum, urine, tissue, amniotic fluid, and microdialysates. These developmental advances have resulted in shorter analysis times – and therefore higher sample throughput – key for large scale metabolic phenotyping studies. Peak detection and analytical reproducibility have been enhanced, improving metabolome coverage and the potential for biomarker identification and quantification.
I am applying these methods to biomedical research areas including toxicology, cardiovascular disease, neonatal disease and development, maternal exposures and effects on early childhood, and neurological diseases.
et al., 2022, Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastoma, Nature Communications, Vol:13, ISSN:2041-1723
et al., 2022, Automated annotation of untargeted all-ion fragmentation LC-MS metabolomics data with MetaboAnnotatoR, Analytical Chemistry, Vol:94, ISSN:0003-2700, Pages:3446-3455
et al., 2021, Lipid profiling of mouse intestinal organoids for studying APC mutations, Bioscience Reports: Molecular and Cellular Biology of the Cell Surface, Vol:41, ISSN:0144-8463, Pages:1-11
et al., 2020, The effects of a ketogenic medium-chain triglyceride diet on the feces in dogs with idiopathic epilepsy, Frontiers in Veterinary Science, Vol:7, ISSN:2297-1769, Pages:1-12
et al., 2020, Leptin and fractalkine: novel subcutaneous cytokines in burn injury, Disease Models and Mechanisms, Vol:13, ISSN:1754-8403