Publications
116 results found
Shariff MIF, Lewis MR, Want EJ, et al., 2012, BLOOD LIPIDOMIC PROFILING OF HEPATOCELLULAR CARCINOMA IN HUMAN AND ANIMAL STUDIES IDENTIFIES LYSOPHOSPHATIDYLCHOLINE (24,0,0), A DISCRIMINATORY BIOMARKER
McPhail MJW, Shawcross D, Coltart I, et al., 2012, METABOLIC PROFILING OF PLASMA BY NMR SPECTROSCOPY ACCURATELY PREDICTS OUTCOME IN PATIENTS WITH DECOMPENSATED CIRRHOSIS AND ACUTE ON CHRONIC LIVER FAILURE, GUT, Vol: 61, Pages: A202-A203, ISSN: 0017-5749
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- Citations: 1
Coltart I, McPhail MJW, Want EJ, et al., 2012, PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY OF PLASMA IN PATIENTS WITH CIRRHOSIS CORRELATES WITH ARTERIAL AMMONIA BUT NOT GRADE OF HEPATIC ENCEPHALOPATHY, GUT, Vol: 61, Pages: A202-A202, ISSN: 0017-5749
Miller JA, Want EJ, Thompson PA, et al., 2012, Application of metabolomics to assess serum profiles in limonene-treated breast cancer patients, CANCER RESEARCH, Vol: 72, ISSN: 0008-5472
Shariff MIF, Lewis MR, Want EJ, et al., 2012, BLOOD LIPIDOMIC PROFILING OF HEPATOCELLULAR CARCINOMA IN HUMAN AND ANIMAL STUDIES IDENTIFIES LYSOPHOSPHATIDYLCHOLINE (24,0,0) AS A DISCRIMINATORY BIOMARKER, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S294-S294, ISSN: 0168-8278
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- Citations: 1
Robinson O, Toledano MB, Goldin R, et al., 2012, HIRMI VALLEY LIVER DISEASE: A TALE OF TWO TOXINS, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S33-S34, ISSN: 0168-8278
McPhail MJW, Shawcross D, Lewis M, et al., 2012, PLASMA PHOSHOLIPID PROFILING BY METABONOMICS: HIGHLY ACCURATE OUTCOME PREDICTION IN DECOMPENSATED CIRRHOSIS, International Liver Congress / 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S557-S557, ISSN: 0168-8278
Langer JK, Koot YEM, Macklon NS, et al., 2012, Prediction of Adverse Pregnancy Outcomes Using Urinary Metabolic Profiling, Society for Gynecological Investigation
Kamleh MA, Ebbels TMD, Spagou K, et al., 2012, Optimizing the Use of Quality Control Samples for Signal Drift Correction in Large-Scale Urine Metabolic Profiling Studies, ANALYTICAL CHEMISTRY, Vol: 84, Pages: 2670-2677, ISSN: 0003-2700
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- Citations: 106
Benton HP, Want E, Keun HC, et al., 2012, Intra- and Interlaboratory Reproducibility of Ultra Performance Liquid Chromatography-Time-of-Flight Mass Spectrometry for Urinary Metabolic Profiling, ANALYTICAL CHEMISTRY, Vol: 84, Pages: 2424-2432, ISSN: 0003-2700
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- Citations: 36
Theodoridis GA, Gika HG, Want EJ, et al., 2012, Liquid chromatography-mass spectrometry based global metabolite profiling: A review, ANALYTICA CHIMICA ACTA, Vol: 711, Pages: 7-16, ISSN: 0003-2670
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- Citations: 373
Graca G, Goodfellow BJ, Barros AS, et al., 2012, UPLC-MS metabolic profiling of second trimester amniotic fluid and maternal urine and comparison with NMR spectral profiling for the identification of pregnancy disorder biomarkers, MOLECULAR BIOSYSTEMS, Vol: 8, Pages: 1243-1254, ISSN: 1742-206X
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- Citations: 84
Veselkov KA, Vingara LK, Masson P, et al., 2011, Response to Comment on "Optimized Preprocessing of Ultra-Performance Liquid Chromatography/Mass Spectrometry Urinary Metabolic Profiles for Improved Information Recovery", ANALYTICAL CHEMISTRY, Vol: 83, Pages: 9721-9722, ISSN: 0003-2700
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- Citations: 2
Veselkov KA, Vingara LK, Masson P, et al., 2011, Optimized Preprocessing of Ultra-Performance Liquid Chromatography/Mass Spectrometry Urinary Metabolic Profiles for Improved Information Recovery, ANALYTICAL CHEMISTRY, Vol: 83, Pages: 5864-5872, ISSN: 0003-2700
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- Citations: 211
Kamleh MA, Spagou K, Want EJ, 2011, Metabolic Profiling in Disease Diagnosis, Toxicology and Personalized Healthcare, CURRENT PHARMACEUTICAL BIOTECHNOLOGY, Vol: 12, Pages: 976-995, ISSN: 1389-2010
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- Citations: 8
Shalhoub J, Vorkas PA, Monaco C, et al., 2011, COMPREHENSIVE METABOLIC PROFILING IN RISK STRATIFICATION OF HUMAN CAROTID ATHEROSCLEROSIS, 79th Congress of the European-Atherosclerosis-Society (EAS), Publisher: ELSEVIER IRELAND LTD, Pages: 151-152, ISSN: 1567-5688
Geier FM, Want EJ, Leroi AM, et al., 2011, Cross-Platform Comparison of <i>Caenorhabditis</i> <i>elegans</i> Tissue Extraction Strategies for Comprehensive Metabolome Coverage, ANALYTICAL CHEMISTRY, Vol: 83, Pages: 3730-3736, ISSN: 0003-2700
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- Citations: 96
Swann JR, Want EJ, Geier FM, et al., 2011, Systemic gut microbial modulation of bile acid metabolism in host tissue compartments, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 108, Pages: 4523-4530, ISSN: 0027-8424
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- Citations: 507
Masson P, Spagou K, Nicholson JK, et al., 2011, Technical and Biological Variation in UPLC-MS-Based Untargeted Metabolic Profiling of Liver Extracts: Application in an Experimental Toxicity Study on Galactosamine, ANALYTICAL CHEMISTRY, Vol: 83, Pages: 1116-1123, ISSN: 0003-2700
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- Citations: 46
Izquierdo-Garcia JL, Peces-Barba G, Heili S, et al., 2011, Is NMR-based metabolomic analysis of exhaled breath condensate accurate?, EUROPEAN RESPIRATORY JOURNAL, Vol: 37, Pages: 468-470, ISSN: 0903-1936
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- Citations: 20
Spagou K, Wilson ID, Masson P, et al., 2011, HILIC-UPLC-MS for Exploratory Urinary Metabolic Profiling in Toxicological Studies, ANALYTICAL CHEMISTRY, Vol: 83, Pages: 382-390, ISSN: 0003-2700
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- Citations: 126
Claus SP, Ellero SL, Berger B, et al., 2011, Colonization-induced host-gut microbial metabolic interaction., mBio, Vol: 2, Pages: e00271-e00210
UNLABELLED: The gut microbiota enhances the host's metabolic capacity for processing nutrients and drugs and modulate the activities of multiple pathways in a variety of organ systems. We have probed the systemic metabolic adaptation to gut colonization for 20 days following exposure of axenic mice (n = 35) to a typical environmental microbial background using high-resolution (1)H nuclear magnetic resonance (NMR) spectroscopy to analyze urine, plasma, liver, kidney, and colon (5 time points) metabolic profiles. Acquisition of the gut microbiota was associated with rapid increase in body weight (4%) over the first 5 days of colonization with parallel changes in multiple pathways in all compartments analyzed. The colonization process stimulated glycogenesis in the liver prior to triggering increases in hepatic triglyceride synthesis. These changes were associated with modifications of hepatic Cyp8b1 expression and the subsequent alteration of bile acid metabolites, including taurocholate and tauromuricholate, which are essential regulators of lipid absorption. Expression and activity of major drug-metabolizing enzymes (Cyp3a11 and Cyp2c29) were also significantly stimulated. Remarkably, statistical modeling of the interactions between hepatic metabolic profiles and microbial composition analyzed by 16S rRNA gene pyrosequencing revealed strong associations of the Coriobacteriaceae family with both the hepatic triglyceride, glucose, and glycogen levels and the metabolism of xenobiotics. These data demonstrate the importance of microbial activity in metabolic phenotype development, indicating that microbiota manipulation is a useful tool for beneficially modulating xenobiotic metabolism and pharmacokinetics in personalized health care. IMPORTANCE: Gut bacteria have been associated with various essential biological functions in humans such as energy harvest and regulation of blood pressure. Furthermore, gut microbial colonization occurs after birth in parallel with other
Want E, Masson P, 2011, Processing and Analysis of GC/LC-MS-Based Metabolomics Data, METABOLIC PROFILING: METHODS AND PROTOCOLS, Vol: 708, Pages: 277-298, ISSN: 1064-3745
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- Citations: 74
Benton HP, Want EJ, Ebbels TMD, 2010, Correction of mass calibration gaps in liquid chromatography-mass spectrometry metabolomics data, BIOINFORMATICS, Vol: 26, Pages: 2488-2489, ISSN: 1367-4803
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- Citations: 133
Ipsen A, Want EJ, Ebbels TMD, 2010, Construction of Confidence Regions for Isotopic Abundance Patterns in LC/MS Data Sets for Rigorous Determination of Molecular Formulas, ANALYTICAL CHEMISTRY, Vol: 82, Pages: 7319-7328, ISSN: 0003-2700
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- Citations: 9
Want EJ, Coen M, Masson P, et al., 2010, Ultra Performance Liquid Chromatography-Mass Spectrometry Profiling of Bile Acid Metabolites in Biofluids: Application to Experimental Toxicology Studies, ANALYTICAL CHEMISTRY, Vol: 82, Pages: 5282-5289, ISSN: 0003-2700
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- Citations: 75
Homapour B, Bowen JE, Want EJ, et al., 2010, Intra-operative, real-time, three-dimensional ultrasound assisted positioning of catheters in the microdialysis of glial tumours, JOURNAL OF CLINICAL NEUROSCIENCE, Vol: 17, Pages: 506-510, ISSN: 0967-5868
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- Citations: 7
Ipsen A, Want E, Lindon J, et al., 2010, Identification of parent-fragment pairs via rigorous statistical modeling of LC-MS metabolomic data, Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727
Ipsen A, Want EJ, Lindon JC, et al., 2010, A statistically rigorous test for the identification of parent-fragment pairs in LC-MS datasets, Analytical Chemistry, Vol: 82, Pages: 1766-1778, ISSN: 1086-4377
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