Imperial College London
Alternate

Dr Elizabeth Want

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3023e.want

 
 
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Location

 

E315CBurlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nagy:2023:10.1097/j.pain.0000000000002709,
author = {Nagy, I and Friston, D and Cuddihy, J and Luiz, J and Truong, A and Laptin, H and Meirvaan, B and Peter, S and Orsolya, O and Joao, V and Tim, M and Sini, J and Helen, L and Declan, C and Marcela, V and Attila, G and Zoltan, T and Gabor, J and Elizabeth, W},
doi = {10.1097/j.pain.0000000000002709},
journal = {Pain},
pages = {e103--e115},
title = {Elevated 18:0 lysophosphatidylcholine contributes to the development of pain in tissue injury},
url = {http://dx.doi.org/10.1097/j.pain.0000000000002709},
volume = {164},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Tissue injuries, including burns, are major causes of death and morbidity worldwide. These injuries result in the release of intracellular molecules and subsequent inflammatory reactions, changing the tissues’ chemical milieu and leading to the development of persistent pain through activating pain-sensing primary sensory neurons. However, the majority of pain-inducing agents in injured tissues are unknown. Here, we report that, amongst other important metabolite changes, lysophosphatidylcholines (LPCs) including 18:0 LPC exhibit significant and consistent local burn injury-induced changes in concentration. 18:0 LPC induces immediate pain and the development of hypersensitivities to mechanical and heat stimuli through molecules including the transient receptor potential ion channel, vanilloid sub-family, member 1 and member 2 at least partly via increasing lateral pressure in the membrane. As levels of LPCs including 18:0 LPC increase in other tissue injuries, our data reveal a novel role for these lipids in injury-associated pain. These findings have high potential to improve patient care.
AU  - Nagy,I
AU  - Friston,D
AU  - Cuddihy,J
AU  - Luiz,J
AU  - Truong,A
AU  - Laptin,H
AU  - Meirvaan,B
AU  - Peter,S
AU  - Orsolya,O
AU  - Joao,V
AU  - Tim,M
AU  - Sini,J
AU  - Helen,L
AU  - Declan,C
AU  - Marcela,V
AU  - Attila,G
AU  - Zoltan,T
AU  - Gabor,J
AU  - Elizabeth,W
DO  - 10.1097/j.pain.0000000000002709
EP  - 115
PY  - 2023///
SN  - 0304-3959
SP  - 103
TI  - Elevated 18:0 lysophosphatidylcholine contributes to the development of pain in tissue injury
T2  - Pain
UR  - http://dx.doi.org/10.1097/j.pain.0000000000002709
UR  - https://journals.lww.com/pain/Abstract/9900/Elevated_18_0_lysophosphatidylcholine_contributes.114.aspx
UR  - http://hdl.handle.net/10044/1/97556
VL  - 164
ER  -
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