Summary
Dr Liz Whittaker is Senior Clinical Lecturer in paediatric infectious diseases and immunology. She divides her time between Imperial College London and the Department of Paediatric Infectious Diseases and Immunology, St. Marys Hospital, London where she is a Consultant.
Dr. Whittaker is the Director of Research for West London Children's Healthcare (WLCH), working closely with the Board of WLCH and Imperial College's Centre of Paediatrics and Child Health (PAECH) to ensure research is embedded in every patient's journey.
Dr Whittaker is the Clinical Lead for Paediatric Infectious Diseases and the co-lead for HCID (high consequence infectious diseases) at St Marys, Imperial College Healthcare NHS Trust. She is the Convenor of the British Paediatric Allergy Infection and Immunity Group (BPAIIG; BPAIIG). She is on the steering committee of the British Association of Paediatric Tuberculosis (BAPT) and works closely with international colleagues in Europe and beyond to improve diagnosis and outcomes in children with TB, through the PTBNET group amongst others.
Her main research interests are the ontogeny of infant immune responses to a variety of pathogens. Her PhD data suggest that children under a year of age have an immaturity of their non-specific T cells or innate immune responses in conjunction with increased numbers of regulatory T cells. She expanded on this theme while an NIHR funded ACL and now by creating generic and specific assays that will examine the maturation of immune responses in children of different ages, from premature infants of different gestation to older children with 'mature' immune systems. The aim of this research is to develop biomarkers of infection for diagnostic purposes in neonates and to understand differences in immature immune responses that may lead to protection for this vulnerable group, either through vaccinations or immunomodulatory interventions in pregnancy and/or the early neonatal period. Understanding these differences is essential for the development of new adjuvants which will increase the efficacy of neonatal vaccinations to such pathogens as CMV, Group B streptococcus & RSV.
Her PhD students work on the impact of viral co-infection on tuberculosis (TB) susceptibility as well as factors that lead to increased susceptibility to TB disease and infection in adolescents.
Liz completed her Wellcome Trust funded PhD project "Immune responses to mycobacteria; the role of age and disease severity" in 2014. The project was supervised by Professor Beate Kampmann at Imperial College and Professors Mark Nicol and Heather Zar at the University of Cape Town, where all of the children were recruited at Red Cross Memorial Children's Hospital. She was fortunate to complete her lab work in the Institute of Infectious Disease and Molecular Medicine in Cape Town, working closely with both Clinical Infectious Diseases Research Initiative (CIDRI) and the South African Tuberculosis Vaccine Initiative (SATVI).
She completed her undergraduate training in medicine at Trinity College, Dublin, Ireland, including an HRB (Health Research Board) funded BSc in Biochemistry. This included a basic research project 'The role of NFkappaB in 5-Lipoxygenase activation' with Prof. Luke O'Neill for which she won the Bruno Orsi Medal for best research project. Following this she trained as a paediatrician in London and was successfully awarded an Academic Clinical Fellowship in Paediatric Infectious Diseases in 2006. The 9 month research period associated with this fellowship allowed her to develop her interest in paediatric infectious diseases and involved a couple of research projects (on TB Biomarkers and Interferon Gamma Release Assays) which resulted in a number of presentations and publications. During this time she was also involved in the setting up of a paediatric TB Europe Network to facilitate collaboration between Paediatricians caring for children with TB and improved care for children with TB in Europe. She completed the Gorgas Diploma Course in Clinical Tropical Medicine in Peru and was awarded a DTM&H in 2009.
She is a member of IMPRINT and INVAR networks.
Publications
Journals
Sanchez Clemente N, Coles C, Paixao ES, et al., 2024, Paediatric, maternal, and congenital mpox: a systematic review and meta-analysis., Lancet Glob Health, Vol:12, Pages:e572-e588
Meinhardt A, Reilly L, Kaliakatsos M, et al., 2024, Novel antivirals for severe enterovirus infection in immunocompromised hosts; a case series., J Infect
RECOVERY Collaborative Group, 2024, Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial, The Lancet Child & Adolescent Health, Vol:8, ISSN:2352-4642, Pages:190-200
Nugawela MD, Pinto Pereira SM, Rojas NK, et al., 2024, Data Resource Profile: the Children and Young People with Long COVID (CLoCk) Study., Int J Epidemiol, Vol:53
Johnston R, Sonnappa S, Goddings A-L, et al., 2024, A review of post COVID syndrome pathophysiology, clinical presentation and management in children and young people., Paediatr Respir Rev