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@article{Götzinger:2020:10.1016/S2352-4642(20)30177-2,
author = {Götzinger, F and Santiago-García, B and Noguera-Julián, A and Lanaspa, M and Lancella, L and Calò, Carducci FI and Gabrovska, N and Velizarova, S and Prunk, P and Osterman, V and Krivec, U and Lo, Vecchio A and Shingadia, D and Soriano-Arandes, A and Melendo, S and Lanari, M and Pierantoni, L and Wagner, N and L'Huillier, AG and Heininger, U and Ritz, N and Bandi, S and Krajcar, N and Rogli, S and Santos, M and Christiaens, C and Creuven, M and Buonsenso, D and Welch, SB and Bogyi, M and Brinkmann, F and Tebruegge, M and Pfefferle, J and Zacharasiewicz, A and Berger, A and Berger, R and Strenger, V and Kohlfürst, DS and Zschocke, A and Bernar, B and Simma, B and Haberlandt, E and Thir, C and Biebl, A and Vanden, Driessche K and Boiy, T and Van, Brusselen D and Bael, A and Debulpaep, S and Schelstraete, P and Pavic, I and Nygaard, U and Glenthoej, JP and Heilmann, Jensen L and Lind, I and Tistsenko, M and Uustalu, Ü and Buchtala, L and Thee, S and Kobbe, R and Rau, C and Schwerk, N and },
doi = {10.1016/S2352-4642(20)30177-2},
journal = {The Lancet Child and Adolescent Health},
pages = {653--661},
title = {COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study},
url = {http://dx.doi.org/10.1016/S2352-4642(20)30177-2},
volume = {4},
year = {2020}
}

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TY  - JOUR
AB  - BackgroundTo date, few data on paediatric COVID-19 have been published, and most reports originate from China. This study aimed to capture key data on children and adolescents with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection across Europe to inform physicians and health-care service planning during the ongoing pandemic.MethodsThis multicentre cohort study involved 82 participating health-care institutions across 25 European countries, using a well established research network—the Paediatric Tuberculosis Network European Trials Group (ptbnet)—that mainly comprises paediatric infectious diseases specialists and paediatric pulmonologists. We included all individuals aged 18 years or younger with confirmed SARS-CoV-2 infection, detected at any anatomical site by RT-PCR, between April 1 and April 24, 2020, during the initial peak of the European COVID-19 pandemic. We explored factors associated with need for intensive care unit (ICU) admission and initiation of drug treatment for COVID-19 using univariable analysis, and applied multivariable logistic regression with backwards stepwise analysis to further explore those factors significantly associated with ICU admission.Findings582 individuals with PCR-confirmed SARS-CoV-2 infection were included, with a median age of 5·0 years (IQR 0·5–12·0) and a sex ratio of 1·15 males per female. 145 (25%) had pre-existing medical conditions. 363 (62%) individuals were admitted to hospital. 48 (8%) individuals required ICU admission, 25 (4%) mechanical ventilation (median duration 7 days, IQR 2–11, range 1–34), 19 (3%) inotropic support, and one (<1%) extracorporeal membrane oxygenation. Significant risk factors for requiring ICU admission in multivariable analyses were being younger than 1 month (odds ratio 5·06, 95% CI 1·72–14·87; p=0·0035), male sex (2·12, 1·06–4·21; p=0·033), p
AU  - Götzinger,F
AU  - Santiago-García,B
AU  - Noguera-Julián,A
AU  - Lanaspa,M
AU  - Lancella,L
AU  - Calò,Carducci FI
AU  - Gabrovska,N
AU  - Velizarova,S
AU  - Prunk,P
AU  - Osterman,V
AU  - Krivec,U
AU  - Lo,Vecchio A
AU  - Shingadia,D
AU  - Soriano-Arandes,A
AU  - Melendo,S
AU  - Lanari,M
AU  - Pierantoni,L
AU  - Wagner,N
AU  - L'Huillier,AG
AU  - Heininger,U
AU  - Ritz,N
AU  - Bandi,S
AU  - Krajcar,N
AU  - Rogli,S
AU  - Santos,M
AU  - Christiaens,C
AU  - Creuven,M
AU  - Buonsenso,D
AU  - Welch,SB
AU  - Bogyi,M
AU  - Brinkmann,F
AU  - Tebruegge,M
AU  - Pfefferle,J
AU  - Zacharasiewicz,A
AU  - Berger,A
AU  - Berger,R
AU  - Strenger,V
AU  - Kohlfürst,DS
AU  - Zschocke,A
AU  - Bernar,B
AU  - Simma,B
AU  - Haberlandt,E
AU  - Thir,C
AU  - Biebl,A
AU  - Vanden,Driessche K
AU  - Boiy,T
AU  - Van,Brusselen D
AU  - Bael,A
AU  - Debulpaep,S
AU  - Schelstraete,P
AU  - Pavic,I
AU  - Nygaard,U
AU  - Glenthoej,JP
AU  - Heilmann,Jensen L
AU  - Lind,I
AU  - Tistsenko,M
AU  - Uustalu,Ü
AU  - Buchtala,L
AU  - Thee,S
AU  - Kobbe,R
AU  - Rau,C
AU  - Schwerk,N
AU  - Barker,M
AU  - Tsolia,M
AU  - Eleftheriou,I
AU  - Gavin,P
AU  - Kozdoba,O
AU  - Zsigmond,B
AU  - Valentini,P
AU  - Ivakeviciene,I
AU  - Ivakevicius,R
AU  - Vilc,V
AU  - Schölvinck,E
AU  - Rojahn,A
AU  - Smyrnaios,A
AU  - Klingenberg,C
AU  - Carvalho,I
AU  - Ribeiro,A
AU  - Starshinova,A
AU  - Solovic,I
AU  - Falcón,L
AU  - Neth,O
AU  - Minguell,L
AU  - Bustillo,M
AU  - Gutiérrez-Sánchez,AM
AU  - Guarch,Ibáñez B
AU  - Ripoll,F
AU  - Soto,B
AU  - Kötz,K
AU  - Zimmermann,P
AU  - Schmid,H
AU  - Zucol,F
AU  - Niederer,A
AU  - Buettcher,M
AU  - Cetin,BS
AU  - Bilogortseva,O
AU  - Chechenyeva,V
AU  - Demirjian,A
AU  - Shackley,F
AU  - McFetridge,L
AU  - Speirs,L
AU  - Doherty,C
AU  - Jones,L
AU  - McMaster,P
AU  - Murray,C
AU  - Child,F
AU  - Beuvink,Y
AU  - Makwana,N
AU  - Whittaker,E
AU  - Williams,A
AU  - Fidler,K
AU  - Bernatoniene,J
AU  - Song,R
AU  - Oliver,Z
AU  - Riordan,A
DO  - 10.1016/S2352-4642(20)30177-2
EP  - 661
PY  - 2020///
SN  - 2352-4642
SP  - 653
TI  - COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study
T2  - The Lancet Child and Adolescent Health
UR  - http://dx.doi.org/10.1016/S2352-4642(20)30177-2
UR  - https://www.sciencedirect.com/science/article/pii/S2352464220301772?via%3Dihub
UR  - http://hdl.handle.net/10044/1/80806
VL  - 4
ER  -

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