Imperial College London
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DrElizabethWhittaker

Faculty of Medicine, Department of Infectious Disease

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

e.whittaker

 
 
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Location

 

PaediatricsNorfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Flood:2021:10.1016/j.lanepe.2021.100075,
author = {Flood, J and Shingleton, J and Bennett, E and Walker, B and Amin-Chowdhury, Z and Oligbu, G and Avis, J and Lynn, RM and Davis, P and Bharucha, T and Pain, CE and Jyothish, D and Whittaker, E and Dwarakanathan, B and Wood, R and Williams, C and Swann, O and Semple, MG and Ramsay, ME and Jones, CE and Ramanan, A and Gent, N and Ladhani, SN},
doi = {10.1016/j.lanepe.2021.100075},
journal = {LANCET REGIONAL HEALTH-EUROPE},
pages = {1--11},
title = {Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020},
url = {http://dx.doi.org/10.1016/j.lanepe.2021.100075},
volume = {3},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundPaediatric Multisystem Inflammatory Syndrome temporally associated with SARS-CoV-2 (PIMS-TS), first identified in April 2020, shares features of both Kawasaki disease (KD) and toxic shock syndrome (TSS). The surveillance describes the epidemiology and clinical characteristics of PIMS-TS in the United Kingdom and Ireland.MethodsPublic Health England initiated prospective national surveillance of PIMS-TS through the British Paediatric Surveillance Unit. Paediatricians were contacted monthly to report PIMS-TS, KD and TSS cases electronically and complete a detailed clinical questionnaire. Cases with symptom onset between 01 March and 15 June 2020 were included.FindingsThere were 216 cases with features of PIMS-TS alone, 13 with features of both PIMS-TS and KD, 28 with features of PIMS-TS and TSS and 11 with features of PIMS-TS, KD and TSS, with differences in age, ethnicity, clinical presentation and disease severity between the phenotypic groups. There was a strong geographical and temporal association between SARS-CoV-2 infection rates and PIMS-TS cases. Of those tested, 14.8% (39/264) children had a positive SARS-CoV-2 RT-PCR, and 63.6% (75/118) were positive for SARS-CoV-2 antibodies. In total 44·0% (118/268) required intensive care, which was more common in cases with a TSS phenotype. Three of five children with cardiac arrest had TSS phenotype. Three children (1·1%) died.InterpretationThe strong association between SARS-CoV-2 infection and PIMS-TS emphasises the importance of maintaining low community infection rates to reduce the risk of this rare but severe complication in children and adolescents. Close follow-up will be important to monitor long-term complications in children with PIMS-TS.FundingPHE.
AU  - Flood,J
AU  - Shingleton,J
AU  - Bennett,E
AU  - Walker,B
AU  - Amin-Chowdhury,Z
AU  - Oligbu,G
AU  - Avis,J
AU  - Lynn,RM
AU  - Davis,P
AU  - Bharucha,T
AU  - Pain,CE
AU  - Jyothish,D
AU  - Whittaker,E
AU  - Dwarakanathan,B
AU  - Wood,R
AU  - Williams,C
AU  - Swann,O
AU  - Semple,MG
AU  - Ramsay,ME
AU  - Jones,CE
AU  - Ramanan,A
AU  - Gent,N
AU  - Ladhani,SN
DO  - 10.1016/j.lanepe.2021.100075
EP  - 11
PY  - 2021///
SN  - 2666-7762
SP  - 1
TI  - Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020
T2  - LANCET REGIONAL HEALTH-EUROPE
UR  - http://dx.doi.org/10.1016/j.lanepe.2021.100075
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000654684600026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S2666776221000521?via%3Dihub
UR  - http://hdl.handle.net/10044/1/90310
VL  - 3
ER  -
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