Imperial College London
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DrElizabethWhittaker

Faculty of Medicine, Department of Infectious Disease

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

e.whittaker

 
 
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Location

 

PaediatricsNorfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Harwood:2022:10.1016/j.eclinm.2022.101287,
author = {Harwood, R and Yan, H and Talawila, Da Camara N and Smith, C and Ward, J and Tudur-Smith, C and Linney, M and Clark, M and Whittaker, E and Saatci, D and Davis, PJ and Luyt, K and Draper, ES and Kenny, SE and Fraser, LK and Viner, RM},
doi = {10.1016/j.eclinm.2022.101287},
journal = {EClinicalMedicine},
title = {Which children and young people are at higher risk of severe disease and death after hospitalisation with SARS-CoV-2 infection in children and young people: A systematic review and individual patient meta-analysis},
url = {http://dx.doi.org/10.1016/j.eclinm.2022.101287},
volume = {44},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: We aimed to describe pre-existing factors associated with severe disease, primarily admission to critical care, and death secondary to SARS-CoV-2 infection in hospitalised children and young people (CYP), within a systematic review and individual patient meta-analysis. Methods: We searched Pubmed, European PMC, Medline and Embase for case series and cohort studies published between 1st January 2020 and 21st May 2021 which included all CYP admitted to hospital with ≥ 30 CYP with SARS-CoV-2 or ≥ 5 CYP with PIMS-TS or MIS-C. Eligible studies contained (1) details of age, sex, ethnicity or co-morbidities, and (2) an outcome which included admission to critical care, mechanical invasive ventilation, cardiovascular support, or death. Studies reporting outcomes in more restricted groupings of co-morbidities were eligible for narrative review. We used random effects meta-analyses for aggregate study-level data and multilevel mixed effect models for IPD data to examine risk factors (age, sex, comorbidities) associated with admission to critical care and death. Data shown are odds ratios and 95% confidence intervals (CI).PROSPERO: CRD42021235338. Findings: 83 studies were included, 57 (21,549 patients) in the meta-analysis (of which 22 provided IPD) and 26 in the narrative synthesis. Most studies had an element of bias in their design or reporting. Sex was not associated with critical care or death. Compared with CYP aged 1-4 years (reference group), infants (aged <1 year) had increased odds of admission to critical care (OR 1.63 (95% CI 1.40-1.90)) and death (OR 2.08 (1.57-2.86)). Odds of death were increased amongst CYP over 10 years (10-14 years OR 2.15 (1.54-2.98); >14 years OR 2.15 (1.61-2.88)).The number of comorbid conditions was associated with increased odds of admission to critical care and death for COVID-19 in a step-wise fashion. Compared with CYP without comorbidity, odds ratios for critical care admission were: 1.49 (1.45-1.53)
AU  - Harwood,R
AU  - Yan,H
AU  - Talawila,Da Camara N
AU  - Smith,C
AU  - Ward,J
AU  - Tudur-Smith,C
AU  - Linney,M
AU  - Clark,M
AU  - Whittaker,E
AU  - Saatci,D
AU  - Davis,PJ
AU  - Luyt,K
AU  - Draper,ES
AU  - Kenny,SE
AU  - Fraser,LK
AU  - Viner,RM
DO  - 10.1016/j.eclinm.2022.101287
PY  - 2022///
SN  - 2589-5370
TI  - Which children and young people are at higher risk of severe disease and death after hospitalisation with SARS-CoV-2 infection in children and young people: A systematic review and individual patient meta-analysis
T2  - EClinicalMedicine
UR  - http://dx.doi.org/10.1016/j.eclinm.2022.101287
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35169689
UR  - http://hdl.handle.net/10044/1/95428
VL  - 44
ER  -
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