Imperial College London
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DrElizabethWhittaker

Faculty of Medicine, Department of Infectious Disease

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

e.whittaker

 
 
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Location

 

PaediatricsNorfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Basu:2019:10.1016/S1473-3099(18)30157-9,
author = {Basu, Roy R and Whittaker, E and Seddon, JA and Kampmann, B},
doi = {10.1016/S1473-3099(18)30157-9},
journal = {Lancet Infectious Diseases},
pages = {e96--e108},
title = {Tuberculosis susceptibility and protection in children},
url = {http://dx.doi.org/10.1016/S1473-3099(18)30157-9},
volume = {19},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Children represent both a clinically important population susceptible to tuberculosis and a key group in whom to study intrinsic and vaccine-induced mechanisms of protection. After exposure to Mycobacterium tuberculosis, children aged under 5 years are at high risk of progressing first to tuberculosis infection, then to tuberculosis disease and possibly disseminated forms of tuberculosis, with accompanying high risks of morbidity and mortality. Children aged 5–10 years are somewhat protected, until risk increases again in adolescence. Furthermore, neonatal BCG programmes show the clearest proven benefit of vaccination against tuberculosis. Case-control comparisons from key cohorts, which recruited more than 15000 children and adolescents in total, have identified that the ratio of monocytes to lymphocytes, activated CD4 T cell count, and a blood RNA signature could be correlates of risk for developing tuberculosis. Further studies of protected and susceptible populations are necessary to guide development of novel tuberculosis vaccines that could facilitate the achievement of WHO's goal to eliminate deaths from tuberculosis in childhood.
AU  - Basu,Roy R
AU  - Whittaker,E
AU  - Seddon,JA
AU  - Kampmann,B
DO  - 10.1016/S1473-3099(18)30157-9
EP  - 108
PY  - 2019///
SN  - 1473-3099
SP  - 96
TI  - Tuberculosis susceptibility and protection in children
T2  - Lancet Infectious Diseases
UR  - http://dx.doi.org/10.1016/S1473-3099(18)30157-9
UR  - http://hdl.handle.net/10044/1/58075
VL  - 19
ER  -
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