Imperial College London
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DrEdwardMullins

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Clinical Senior Lecturer in Obstetrics (Public, Global and D
 
 
 
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Contact

 

edward.mullins Website CV

 
 
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Location

 

St Mary's HospitalClarence WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mullins:2022:10.1371/journal.pone.0273966,
author = {Mullins, E and McCabe, R and Bird, SM and Randell, P and Pond, MJ and Regan, L and Parker, E and McClure, M and Donnelly, CA},
doi = {10.1371/journal.pone.0273966},
journal = {PLoS One},
pages = {e0273966--e0273966},
title = {Tracking the incidence and risk factors for SARS-CoV-2 infection using historical maternal booking serum samples},
url = {http://dx.doi.org/10.1371/journal.pone.0273966},
volume = {17},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The early transmission dynamics of SARS-CoV-2 in the UK are unknown but their investigation is critical to aid future pandemic planning. We tested over 11,000 anonymised, stored historic antenatal serum samples, given at two north-west London NHS trusts in 2019 and 2020, for total antibody to SARS-CoV-2 receptor binding domain (anti-RBD). Estimated prevalence of seroreactivity increased from 1% prior to mid-February 2020 to 17% in September 2020. Our results show higher prevalence of seroreactivity to SARS-CoV-2 in younger, non-white ethnicity, and more deprived groups. We found no significant interaction between the effects of ethnicity and deprivation. Derived from prevalence, the estimated incidence of seroreactivity reflects the trends observed in daily hospitalisations and deaths in London that followed 10 and 13 days later, respectively. We quantified community transmission of SARS-CoV-2 in London, which peaked in late March / early April 2020 with no evidence of community transmission until after January 2020. Our study was not able to determine the date of introduction of the SARS-CoV-2 virus but demonstrates the value of stored antenatal serum samples as a resource for serosurveillance during future outbreaks.
AU  - Mullins,E
AU  - McCabe,R
AU  - Bird,SM
AU  - Randell,P
AU  - Pond,MJ
AU  - Regan,L
AU  - Parker,E
AU  - McClure,M
AU  - Donnelly,CA
DO  - 10.1371/journal.pone.0273966
EP  - 0273966
PY  - 2022///
SN  - 1932-6203
SP  - 0273966
TI  - Tracking the incidence and risk factors for SARS-CoV-2 infection using historical maternal booking serum samples
T2  - PLoS One
UR  - http://dx.doi.org/10.1371/journal.pone.0273966
UR  - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0273966
UR  - http://hdl.handle.net/10044/1/99472
VL  - 17
ER  -
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