Imperial College London
Alternate

ProfessorElaineHolmes

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Chemical Biology
 
 
 
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Contact

 

+44 (0)20 7594 3220elaine.holmes

 
 
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Location

 

661Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Antcliffe:2018:10.1038/s41598-018-32938-6,
author = {Antcliffe, D and Wolfer, A and O'Dea, K and Takata, M and Holmes, E and Gordon, AC},
doi = {10.1038/s41598-018-32938-6},
journal = {Scientific Reports},
title = {Profiling inflammatory markers in patients with pneumonia on intensive care},
url = {http://dx.doi.org/10.1038/s41598-018-32938-6},
volume = {8},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Clinical investigations lack predictive value when diagnosing pneumonia, especially when patients are ventilated and develop ventilator associated pneumonia (VAP). New tools to aid diagnosis are important to improve outcomes. This pilot study examines the potential for a panel of inflammatory mediators to aid in the diagnosis. Forty-four ventilated patients, 17 with pneumonia and 27 with brain injuries, eight of whom developed VAP, were recruited. 51 inflammatory mediators, including cytokines and oxylipins, were measured in patients’ serum using flow cytometry and mass spectrometry. The mediators could separate patients admitted to ICU with pneumonia compared to brain injury with an area under the receiver operating characteristic curve (AUROC) 0.75 (0.61–0.90). Changes in inflammatory mediators were similar in both groups over the course of ICU stay with 5,6-dihydroxyeicosatrienoic and 8,9-dihydroxyeicosatrienoic acids increasing over time and interleukin-6 decreasing. However, brain injured patients who developed VAP maintained inflammatory profiles similar to those at admission. A multivariate model containing 5,6-dihydroxyeicosatrienoic acid, 8,9-dihydroxyeicosatrienoic acid, intercellular adhesion molecule-1, interleukin-6, and interleukin-8, could differentiate patients with VAP from brain injured patients without infection (AUROC 0.94 (0.80–1.00)). The use of a selected group of markers showed promise to aid the diagnosis of VAP especially when combined with clinical data.
AU  - Antcliffe,D
AU  - Wolfer,A
AU  - O'Dea,K
AU  - Takata,M
AU  - Holmes,E
AU  - Gordon,AC
DO  - 10.1038/s41598-018-32938-6
PY  - 2018///
SN  - 2045-2322
TI  - Profiling inflammatory markers in patients with pneumonia on intensive care
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-018-32938-6
UR  - http://hdl.handle.net/10044/1/64940
VL  - 8
ER  -
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