Imperial College London
Alternate

ProfessorElaineHolmes

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Chemical Biology
 
 
 
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Contact

 

+44 (0)20 7594 3220elaine.holmes

 
 
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Location

 

661Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Liu:2018:10.1021/acs.jproteome.8b00583,
author = {Liu, Z and Xia, B and Saric, J and Utzinger, J and Holmes, E and Keiser, J and Li, JV},
doi = {10.1021/acs.jproteome.8b00583},
journal = {Journal of Proteome Research},
pages = {3565--3573},
title = {Effects of vancomycin and ciprofloxacin on the NMRI mouse metabolism},
url = {http://dx.doi.org/10.1021/acs.jproteome.8b00583},
volume = {17},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The reduction in gut microbiota diversity is associated with a range of human diseases. Overuse of antibiotics has been associated with a diminished gut-microbial diversity in humans and may promote microbiota-associated negative effects to physical health, such as the metabolic syndrome-cluster of diseases and mental illnesses. There is a pressing need to deepen the understanding of the effects of antibiotics at the biochemical level. The current study investigated metabolic effects of two widely prescribed antibiotics–vancomycin and ciprofloxacin–on biofluids and brain tissue samples of NMRI female mice using a 1H nuclear magnetic resonance (NMR) spectroscopy-based metabolic profiling approach. While both antibiotics significantly affected the host metabolic signatures of urine and feces, only ciprofloxacin induced metabolic changes in plasma. Metabolic perturbations were pronounced 1 day post-treatment, reverting back to baseline at day 20 post-treatment. Both antibiotics induced changes in the choline metabolism, host-microbial cometabolites, short chain fatty acid production, and protein/purine degradation. The metabolic profiles of brain tissue aqueous extracts did not show any antibiotics-related changes by day 20 post-treatment. The data suggest that the metabolic disruptions in biofluids caused by antibiotics are reversed by day 20 post-treatment when compared to the pre-treatment profiles.
AU  - Liu,Z
AU  - Xia,B
AU  - Saric,J
AU  - Utzinger,J
AU  - Holmes,E
AU  - Keiser,J
AU  - Li,JV
DO  - 10.1021/acs.jproteome.8b00583
EP  - 3573
PY  - 2018///
SN  - 1535-3893
SP  - 3565
TI  - Effects of vancomycin and ciprofloxacin on the NMRI mouse metabolism
T2  - Journal of Proteome Research
UR  - http://dx.doi.org/10.1021/acs.jproteome.8b00583
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000447118300022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/70402
VL  - 17
ER  -
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