Imperial College London
Alternate

ProfessorElaineHolmes

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Chemical Biology
 
 
 
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Contact

 

+44 (0)20 7594 3220elaine.holmes

 
 
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Location

 

661Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Alsaleh:2019:10.1016/j.jceh.2019.06.005,
author = {Alsaleh, M and Sithithaworn, P and Khuntikeo, N and Loilome, W and Yongvanit, P and Chamadol, N and Hughes, T and O'Connor, T and Holmes, E and Taylor-Robinson, S},
doi = {10.1016/j.jceh.2019.06.005},
journal = {Journal of Clinical and Experimental Hepatology},
pages = {657--675},
title = {Characterisation of the urinary metabolic profile of liver fluke-associated cholangiocarcinoma},
url = {http://dx.doi.org/10.1016/j.jceh.2019.06.005},
volume = {9},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background Human infection with Opisthorchis viverrini, a carcinogenic liver uke inhabiting the biliary tree, is endemic in South-East Asia. Chronic infection is associated with a fatal complication, cholangiocarcinoma, a late-presenting and aggressive malignancy. Currently, annual mortality rates from cholangiocarcinoma mirror trends in incidence, due in part to limited availability of efcient prognostic and early diagnostic biomarkers. With ability to detect thousands of urinary metabolites using metabonomics, the urine metabolome holds great potential in providing an insight into system-level alterations in carcinogenesis and in identifying metabolic markers altered in response to disturbed homeostasis. Methods Global molecular proling using reversed-phase ultra-performance liquid-chomatography mass spectrometry (RP-UPLC-MS) was utilised to acquire the urinary spectral prole of 137 Thai subjects (48 at high risk of infection, 41 with O. viverrini infection, 34 periportal brosis and 14 cholangiocarcinoma) from Khon Kaen, Thailand.Results Multivariate statistical analysis identied perturbation in several molecular classes related to purine metabolism and lipid metabolism in the cholangiocarcinoma urine metabolome. These markers mainly reect changes in energy metabolism to support proliferation (increased fatty acid oxidation and purine recycling), DNA methylation and hepatic injury.Conclusions Several metabolites of biological interest were discovered from this proof-of-principle dataset. Augmenting these ndings is essential to accelerate the development of urinary metabolic markers in cholangiocarcinoma.
AU  - Alsaleh,M
AU  - Sithithaworn,P
AU  - Khuntikeo,N
AU  - Loilome,W
AU  - Yongvanit,P
AU  - Chamadol,N
AU  - Hughes,T
AU  - O'Connor,T
AU  - Holmes,E
AU  - Taylor-Robinson,S
DO  - 10.1016/j.jceh.2019.06.005
EP  - 675
PY  - 2019///
SN  - 0973-6883
SP  - 657
TI  - Characterisation of the urinary metabolic profile of liver fluke-associated cholangiocarcinoma
T2  - Journal of Clinical and Experimental Hepatology
UR  - http://dx.doi.org/10.1016/j.jceh.2019.06.005
UR  - https://www.sciencedirect.com/science/article/pii/S0973688319301616?via%3Dihub
UR  - http://hdl.handle.net/10044/1/72207
VL  - 9
ER  -
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