Imperial College London
Alternate

ProfessorElaineHolmes

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Chemical Biology
 
 
 
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Contact

 

+44 (0)20 7594 3220elaine.holmes

 
 
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Location

 

661Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Barton:2021:10.1002/tsm2.215,
author = {Barton, W and Cronin, O and GarciaPerez, I and Whiston, R and Holmes, E and Woods, T and Molloy, CB and Molloy, MG and Shanahan, F and Cotter, PD and OSullivan, O},
doi = {10.1002/tsm2.215},
journal = {Translational Sports Medicine},
pages = {174--192},
title = {The effects of sustained fitness improvement on the gut microbiome: A longitudinal, repeated measures casestudy approach},
url = {http://dx.doi.org/10.1002/tsm2.215},
volume = {4},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The athlete gut microbiome differs from that of nonathletes in its composition and metabolic function. Shortterm fitness improvement in sedentary adults does not replicate the microbiome characteristics of athletes. The objective of this study was to investigate whether sustained fitness improvement leads to pronounced alterations in the gut microbiome. This was achieved using a repeatedmeasures, casestudy approach that examined the gut microbiome of two initially unfit volunteers undertaking progressive exercise training over a 6month period. Samples were collected every two weeks, and microbiome, metabolome, diet, body composition, and cardiorespiratory fitness data were recorded. Training culminated in both participants completing their respective goals (a marathon or Olympicdistance triathlon) with improved body composition and fitness parameters. Increases in gut microbiota αdiversity occurred with sustained training and fluctuations occurred in response to training events (eg, injury, illness, and training peaks). Participants’ BMI reduced during the study and was significantly associated with increased urinary measurements of Nmethyl nicotinate and hippurate, and decreased phenylacetylglutamine. These results suggest that sustained fitness improvements support alterations to gut microbiota and physiologicallyrelevant metabolites. This study provides longitudinal analysis of the gut microbiome response to realworld events during progressive fitness training, including intercurrent illness and injury.
AU  - Barton,W
AU  - Cronin,O
AU  - GarciaPerez,I
AU  - Whiston,R
AU  - Holmes,E
AU  - Woods,T
AU  - Molloy,CB
AU  - Molloy,MG
AU  - Shanahan,F
AU  - Cotter,PD
AU  - OSullivan,O
DO  - 10.1002/tsm2.215
EP  - 192
PY  - 2021///
SN  - 2573-8488
SP  - 174
TI  - The effects of sustained fitness improvement on the gut microbiome: A longitudinal, repeated measures casestudy approach
T2  - Translational Sports Medicine
UR  - http://dx.doi.org/10.1002/tsm2.215
UR  - https://onlinelibrary.wiley.com/doi/10.1002/tsm2.215
UR  - http://hdl.handle.net/10044/1/85624
VL  - 4
ER  -
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