Imperial College London
Alternate

ProfessorElaineHolmes

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Chemical Biology
 
 
 
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Contact

 

+44 (0)20 7594 3220elaine.holmes

 
 
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Location

 

661Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Alsaleh:2021:10.1038/s41598-021-00530-0,
author = {Alsaleh, M and Leftley, Z and OConnor, T and Hughes, T and Barbera, T and Koomson, L and Zabron, A and Reeves, H and Cramp, M and Ryder, S and Greer, S and Sithithaworn, P and Khuntikeo, N and Loilome, W and Yongvanit, P and Prince, M and Cox, IJ and Williams, R and Wadsworth, C and Holmes, E and Nash, K and Andrews, R and Taylor-Robinson, S},
doi = {10.1038/s41598-021-00530-0},
journal = {Scientific Reports},
pages = {1--12},
title = {Mapping of population disparities in the cholangiocarcinoma urinary metabolome},
url = {http://dx.doi.org/10.1038/s41598-021-00530-0},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Phenotypic diversity in urinary metabolomes of different geographical populations has been recognized recently. In this study, urinary metabolic signatures from Western (United Kingdom) and South-East Asian (Thai) cholangiocarcinoma patients were characterized to understand spectral variability due to host carcinogenic processes and/or exogenous differences (nutritional, environmental and pharmaceutical). Urinary liquid chromatography mass spectroscopy (LC–MS) spectral profiles from Thai (healthy = 20 and cholangiocarcinoma = 14) and UK cohorts (healthy = 22 and cholangiocarcinoma = 10) were obtained and modelled using chemometric data analysis. Healthy metabolome disparities between the two distinct populations were primarily related to differences in dietary practices and body composition. Metabolites excreted due to drug treatment were dominant in urine specimens from cholangiocarcinoma patients, particularly in Western individuals. Urine from participants with sporadic (UK) cholangiocarcinoma contained greater levels of a nucleotide metabolite (uridine/pseudouridine). Higher relative concentrations of 7-methylguanine were observed in urine specimens from Thai cholangiocarcinoma patients. The urinary excretion of hippurate and methyladenine (gut microbial-host co-metabolites) showed a similar pattern of lower levels in patients with malignant biliary tumours from both countries. Intrinsic (body weight and body composition) and extrinsic (xenobiotic metabolism) factors were the main causes of disparities between the two populations. Regardless of the underlying aetiology, biological perturbations associated with cholangiocarcinoma urine metabolome signatures appeared to be influenced by gut microbial community metabolism. Dysregulation in nucleotide metabolism was associated with sporadic cholangiocarcinoma, possibly indicating differences in mitochondrial energy production pathways between cholangiocar
AU  - Alsaleh,M
AU  - Leftley,Z
AU  - OConnor,T
AU  - Hughes,T
AU  - Barbera,T
AU  - Koomson,L
AU  - Zabron,A
AU  - Reeves,H
AU  - Cramp,M
AU  - Ryder,S
AU  - Greer,S
AU  - Sithithaworn,P
AU  - Khuntikeo,N
AU  - Loilome,W
AU  - Yongvanit,P
AU  - Prince,M
AU  - Cox,IJ
AU  - Williams,R
AU  - Wadsworth,C
AU  - Holmes,E
AU  - Nash,K
AU  - Andrews,R
AU  - Taylor-Robinson,S
DO  - 10.1038/s41598-021-00530-0
EP  - 12
PY  - 2021///
SN  - 2045-2322
SP  - 1
TI  - Mapping of population disparities in the cholangiocarcinoma urinary metabolome
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-021-00530-0
UR  - https://www.nature.com/articles/s41598-021-00530-0
UR  - http://hdl.handle.net/10044/1/92644
VL  - 11
ER  -
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