Imperial College London
Alternate

ProfessorElaineHolmes

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Chemical Biology
 
 
 
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Contact

 

+44 (0)20 7594 3220elaine.holmes

 
 
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Location

 

661Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Yeung:2022,
author = {Yeung, KTD and Penney, N and Whiley, L and Ashrafian, H and Lewis, M and Purkayastha, S and Darzi, A and Holmes, E},
journal = {Scientific Reports},
title = {The impact of bariatric surgery on serum tryptophan-kynurenine pathway metabolites},
url = {https://www.nature.com/articles/s41598-021-03833-4},
volume = {12},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objectives: This study aims to explore the immediate effects of bariatric surgery on serum  tryptophan  –  kynurenine  pathway  metabolites  in  individuals  with  type  2 diabetes  and  BMI  >30.  With  the  goal  of  providing  insight  into  the  link  between tryptophan  pathway  metabolites,  type  2  diabetes,  and  chronic  obesity-induced inflammation. Methods: This longitudinal study included 20 participants. Half were diagnosed with type 2 diabetes. 11 and 9 underwent RYGB and SG respectively. Blood samples were obtained at pre-operative and three months post-operative timepoints. Tryptophan and  downstream  metabolites  of  the  kynurenine  pathway  were  quantified  with  an ultrahigh-performance  liquid  chromatography  tandem  mass  spectrometry  with electrospray ionisation method.  Results:  At 3 months post-operation, RYGB led to significant reductions in tryptophan, kynurenic acid and xanthurenic acid levels when compared to baseline. Significant reductions of the same metabolites after surgery were also observed in individuals with  T2D  irrespective  of  surgical  procedure.  These  metabolites  were  significantly correlated with serum HbA1c levels and BMI. Conclusions: Bariatric surgery, in particular RYGB reduces serum levels of tryptophan and its downstream kynurenine metabolites. These metabolites are associated with T2D and thought to be potentially mechanistic in the systemic processes of obesity induced  inflammation  leading  to  insulin  resistance.  Its  reduction  after  surgery  is associated with an improvement in glycaemic control (HbA1c).
AU  - Yeung,KTD
AU  - Penney,N
AU  - Whiley,L
AU  - Ashrafian,H
AU  - Lewis,M
AU  - Purkayastha,S
AU  - Darzi,A
AU  - Holmes,E
PY  - 2022///
SN  - 2045-2322
TI  - The impact of bariatric surgery on serum tryptophan-kynurenine pathway metabolites
T2  - Scientific Reports
UR  - https://www.nature.com/articles/s41598-021-03833-4
UR  - http://hdl.handle.net/10044/1/93193
VL  - 12
ER  -
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