Imperial College London
Alternate

ProfessorElaineHolmes

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Chemical Biology
 
 
 
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Contact

 

+44 (0)20 7594 3220elaine.holmes

 
 
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Location

 

661Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bracewell-Milnes:2017:humupd/dmx023,
author = {Bracewell-Milnes, T and Saso, S and Abdalla, H and Nikolau, D and Norman-Taylor, J and Johnson, M and Holmes, E and Thum, M-Y},
doi = {humupd/dmx023},
journal = {Human Reproduction Update},
pages = {723--736},
title = {Metabolomics as a tool to identify biomarkers to predict and improve outcomes in reproductive medicine: a systematic review},
url = {http://dx.doi.org/10.1093/humupd/dmx023},
volume = {23},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUNDInfertility is a complex disorder with significant medical, psychological and financial consequences for patients. With live-birth rates per cycle below 30% and a drive from the Human Fertilisation and Embryology Authority (HFEA) to encourage single embryo transfer, there is significant research in different areas aiming to improve success rates of fertility treatments. One such area is investigating the causes of infertility at a molecular level, and metabolomics techniques provide a platform for studying relevant biofluids in the reproductive tract.OBJECTIVE AND RATIONALEThe aim of this systematic review is to examine the recent findings for the potential application of metabolomics to female reproduction, specifically to the metabolomics of follicular fluid (FF), embryo culture medium (ECM) and endometrial fluid. To our knowledge no other systematic review has investigated this topic.SEARCH METHODSEnglish peer-reviewed journals on PubMed, Science Direct, SciFinder, were systematically searched for studies investigating metabolomics and the female reproductive tract with no time restriction set for publications. Studies were assessed for quality using the risk of bias assessment and ROBIN-I.OUTCOMESThere were 21 studies that met the inclusion criteria and were included in the systematic review. Metabolomic studies have been employed for the compositional analysis of various biofluids in the female reproductive tract, including FF, ECM, blastocoele fluid and endometrial fluid. There is some weak evidence that metabolomics technologies studying ECM might be able to predict the viability of individual embryos and implantation rate better than standard embryo morphology, However these data were not supported by randomized the controlled trials (RCTs) which showed no evidence that using metabolomics is able to improve the most important reproductive outcomes, such as clinical pregnancy and live-birth rates. This systematic review provides guidance for future
AU  - Bracewell-Milnes,T
AU  - Saso,S
AU  - Abdalla,H
AU  - Nikolau,D
AU  - Norman-Taylor,J
AU  - Johnson,M
AU  - Holmes,E
AU  - Thum,M-Y
DO  - humupd/dmx023
EP  - 736
PY  - 2017///
SN  - 1355-4786
SP  - 723
TI  - Metabolomics as a tool to identify biomarkers to predict and improve outcomes in reproductive medicine: a systematic review
T2  - Human Reproduction Update
UR  - http://dx.doi.org/10.1093/humupd/dmx023
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000413533000006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/71445
VL  - 23
ER  -
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