Summary
Education AND Honours
1960 - Cambridge University - BA, Natural Sciences,
1963 - Cambridge University, Veterinary School - VetMB
1964 - Cambridge University - MA
1999 - Elected Fellow of Academy of Medical Sciences, London
2000 - OBE
2010 - Elected honorary Fellow of the Royal College of Veterinary Surgeons
2010 - Elected Fellow of the Royal Society
2015 - HonDSc Imperial College
2019 - 'Outstanding Contribution to Science for Lifetime Achievements in Immunology and Inflammation' - QMUL
Posts held
Imperial College
2004 – present, Emeritus Professor of Transplantation Biology,
1999 – 2004, Deputy Director, Clinical Sciences Centre, IC
1984 – 2004 - Head, Transplantation Biology Group, Clinical Research Centre, Harrow and, since 1994, at the Clinical Sciences Centre, Hammersmith Hospital, RPMS/IC
CRC, Harrow
1971-1984 - Research Scientist in Section of Transplantation
USA 1972-1973 - Visiting Associate, Immunology Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA.
1976 – present - Summer visiting scientist, Jax Laboratory, USA
NIMR
1969-1971 - Research scientist at NIMR, Mill Hill London, NW7
1970-1971 - WHO Consultant Immunologist, NICD, Delhi, India.
Cambridge Canada
1966-1969 - Assistant Lecturer, Animal Pathology, Cambridge
1965-1966 - Virologist, Department of Health and Welfare, Ottawa,
1963-1965 - Veterinary surgeon, private practice, NB, Canada.
Sometime member Editorial Boards
Eur J Imm, Transplantation, Cellular Immunology, Immunology,
Immunogenetics, Scandinavian Journal of Immunology
Immunology Today
Transmitting editor, International Immunology
Referee for: Nature, Cell, Journal of Immunology, PNAS, Immunity, Science, Proc.Natl.Acad.Sci., Blood, BJC and others.
Committees
MRC: Cell Board member 1983-87
Cell Board A Grants Committee Chairman, 1984-87
MRC Animals Research Committee member 1993 - 2003
AFRC: Animals Research Grants Boards member 1989-1992
Cancer Research Campaign: Grants Committee member 1992-01
Scientific Committee member 2000-2002
Cancer Research UK: Programmes Committee member 2002-2006
Projects Committee Chairman 2003-2006
Scientific Executive Board member 2004-2006
Fellowships interview panel member 2002-2007
Wellcome Trust: Infection and Immunity Panel member 1992-1997
Genetics Interest Group member 1993-1998
Clinical Research fellowship panel - member 2006-present
Veterinary Research fellowship panel Chairman 2007- present
Roslin Institute Director’s Advisory Board member 1994-2001
Cobra Therapeutics Ltd. Scientific Advisory Board 1998-2000
Gensel: Scientific Advisory Board, 1999-2001
Royal Society: Dorothy Hodgkin Fellowship panel member 2005-10
Leverhulme Trust Senior Fellowship Panel 2011
Selection Committee Panel Member 2012-2014
RS Biographical Memoirs Editorial Board member 2015 - present
Chairman RS Newton International Fellowships Panel 2018 - present
Government of South Korea: science funding advisor, 2006-2012
Oxford University: Scientific Advisory Committee Member 2010-2016
Research
The molecular nature of epitopes recognised by T cells with particular reference to transplantation, autoimmunity and tumour immunity; the genetic control of immune responses to T cell epitopes with respect to MHC and non-MHC linked genes.
Recent publications:
C1q enhances IFN-gamma production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cell . Baruah P, Dumitriu IE, Malik TH, Cook HT, Dyson J, Scott D, Simpson E, Botto M. Blood. 2009 113:3485-93.
Concomitant Tumor and Minor Histocompatibility Antigen-Specific Immunity Initiate Rejection and Maintain Remission from Established Spontaneous Solid Tumors. Hess Michelini R, Freschi M, Manzo T, Jachetti E, Degl'innocenti E, Grioni M, Basso V, Bonini C, Simpson E, Mondino A, et al. Cancer Res 2010 70:3505-14
Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance. Baruah P, Simpson E, Dumitriu IE, Derbyshire K, Coe D, Addey C, Dyson J, Chai JG, Cook T, Scott D, et al.Botto M Eur J Immunol 2010 40:1758-1767
The roles of antigen-specificity, responsiveness to TGFβ and APC subsets in tumour-induced expansion of regulatory T cells. Coe, David; Addey, Caroline; White, Matthew; Simpson, Elizabeth; Dyson, P J; Chai, JG. Immunology, in press 2010
Selected Publications
Journal Articles
Simpson E, 2015, Medawar's legacy to cellular immunology and clinical transplantation: a commentary on Billingham, Brent and Medawar (1956) 'Quantitative studies on tissue transplantation immunity. III. Actively acquired tolerance', Philosophical Transactions of the Royal Society B: Biological Sciences, Vol:370, ISSN:1471-2970
Manzo T, Michelini RH, Basso V, et al., 2011, Concurrent Allorecognition Has a Limited Impact on Posttransplant Vaccination, Journal of Immunology, Vol:186, ISSN:0022-1767, Pages:1361-1368
Baruah P, Simpson E, Dumitriu IE, et al., 2010, Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance, European Journal of Immunology, Vol:40, ISSN:0014-2980, Pages:1758-1767
Michelini RH, Freschi M, Manzo T, et al., 2010, Concomitant Tumor and Minor Histocompatibility Antigen-Specific Immunity Initiate Rejection and Maintain Remission from Established Spontaneous Solid Tumors, Cancer Research, Vol:70, ISSN:0008-5472, Pages:3505-3514
Baruah P, Dumitriu IE, Malik TH, et al., 2009, C1q enhances IFN-gamma production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells, Blood, Vol:113, ISSN:0006-4971, Pages:3485-3493
Greenlaw RE, Gardner NJ, Farrar CA, et al., 2008, An antibody combination that targets activated T cells extends graft survival in sensitized recipients, American Journal of Transplantation, Vol:8, ISSN:1600-6135, Pages:2272-2282
Chai J-G, Coe D, Chen D, et al., 2008, In vitro expansion improves in vivo regulation by CD4(+)CD25(+) regulatory T cells, Journal of Immunology, Vol:180, ISSN:0022-1767, Pages:858-869