Publications
224 results found
Simpson E, Dazzi F, 2019, Bone Marrow Transplantation 1957-2019, Frontiers in Immunology, Vol: 10, ISSN: 1664-3224
Clinical bone marrow transplantation started in 1957 at a time when remarkably little was known about hematopoietic stems cells, immune responses to transplants or the identity of transplant antigens. This review will delineate the substantial increase in knowledge about these three areas gained between then and 1992 when the Ceppellini School course on Bone Marrow Transplantation was held, along with the progress made in clinical application, as well as the stumbling blocks that remained to be overcome by further research to advance knowledge. It will outline the significant progress made between 1992 and the present year, 2019, and the remaining problems.
Simpson E, 2015, Medawar's legacy to cellular immunology and clinical transplantation: a commentary on Billingham, Brent and Medawar (1956) 'Quantitative studies on tissue transplantation immunity. III. Actively acquired tolerance', Philosophical Transactions of the Royal Society B: Biological Sciences, Vol: 370, ISSN: 1471-2970
‘Quantitative studies on tissue transplantation immunity. III. Actively acquired tolerance’, published in Philosophical Transactions B in 1956 by Peter Medawar and his colleagues, PhD graduate Leslie Brent and postdoctoral fellow Rupert Billingham, is a full description of the concept of acquired transplantation tolerance. Their 1953 Nature paper (Billingham RE et al. 1953 Nature 172, 603–606. (doi:10.1038/172603a0)) had provided initial evidence with experimental results from a small number of neonatal mice, with mention of similar findings in chicks. The Philosophical Transactions B 1956 paper is clothed with an astonishing amount of further experimental detail. It is written in Peter Medawar's landmark style: witty, perceptive and full of images that can be recalled even when details of the supporting information have faded. Those images are provided not just by a series of 20 colour plates showing skin graft recipient mice, rats, rabbits, chickens and duck, bearing fur or plumage of donor origin, but by his choice of metaphor, simile and analogy to express the questions being addressed and the interpretation of their results, along with those of relevant published data and his prescient ideas of what the results might portend. This work influenced both immunology researchers and clinicians and helped to lay the foundations for successful transplantation programmes. It led to the award of a Nobel prize in 1960 to Medawar, and subsequently to several scientists who advanced these areas. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society.
Fossati-Jimack L, Ling GS, Baudino L, et al., 2015, Intranasal peptide-induced tolerance and linked suppression: consequences of complement deficiency, IMMUNOLOGY, Vol: 144, Pages: 149-157, ISSN: 0019-2805
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- Citations: 5
Baudino L, Sardini A, Ruseva MM, et al., 2014, C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens, Proceedings of the National Academy of Sciences of the United States of America, Vol: 111, Pages: 1503-1508, ISSN: 0027-8424
Eljaafari A, Yuruker O, Ferrand C, et al., 2013, Isolation of Human CD4/CD8 Double-Positive, Graft-Versus-Host Disease-Protective, Minor Histocompatibility Antigen-Specific Regulatory T Cells and of a Novel HLA-DR7-Restricted HY-Specific CD4 Clone, JOURNAL OF IMMUNOLOGY, Vol: 190, Pages: 184-194, ISSN: 0022-1767
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- Citations: 21
Moreau A, Noble A, Ratnasothy K, et al., 2012, Absence of Galectin-1 accelerates CD8<SUP>+</SUP> T cell-mediated graft rejection, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 42, Pages: 2881-2888, ISSN: 0014-2980
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- Citations: 14
Ling GS, Fossati-Jimack L, Szajna M, et al., 2011, Intranasal tolerance induction is maintained in mice lacking CD11b but through different mechanisms, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 196-196, ISSN: 0019-2805
Simpson E, 2011, Examination of Ohno's Hypothesis with Anne McLaren: Separation of HY and TDY, 44th Annual Meeting of the Society-for-the-Study-of-Reproduction (SSR), Publisher: SOC STUDY REPRODUCTION, ISSN: 0006-3363
Manzo T, Michelini RH, Basso V, et al., 2011, Non myeloablative allogeneic transplantation and tumor-specific vaccination promote eradication of advanced prostate cancer, 25th Conference on European Immunogenetics and Histocompatibility, Publisher: WILEY-BLACKWELL, Pages: 375-376, ISSN: 0001-2815
Manzo T, Michelini RH, Basso V, et al., 2011, Concurrent Allorecognition Has a Limited Impact on Posttransplant Vaccination, JOURNAL OF IMMUNOLOGY, Vol: 186, Pages: 1361-1368, ISSN: 0022-1767
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- Citations: 5
Coe D, Addey C, White M, et al., 2010, The roles of antigen-specificity, responsiveness to transforming growth factor-β and antigen-presenting cell subsets in tumour-induced expansion of regulatory T cells, IMMUNOLOGY, Vol: 131, Pages: 556-569, ISSN: 0019-2805
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- Citations: 11
Manzo T, Michelini RH, Freschi M, et al., 2010, Allogeneic Transplantation and Tumor-Specific Vaccination Promote Infiltration and Eradication of Advanced Prostate Cancer, JOURNAL OF IMMUNOTHERAPY, Vol: 33, Pages: 902-903, ISSN: 1524-9557
Baruah P, Simpson E, Dumitriu IE, et al., 2010, Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 40, Pages: 1758-1767, ISSN: 0014-2980
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- Citations: 26
Michelini RH, Freschi M, Manzo T, et al., 2010, Concomitant Tumor and Minor Histocompatibility Antigen-Specific Immunity Initiate Rejection and Maintain Remission from Established Spontaneous Solid Tumors, CANCER RESEARCH, Vol: 70, Pages: 3505-3514, ISSN: 0008-5472
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- Citations: 20
Baruah P, Dumitriu IE, Malik TH, et al., 2009, C1q enhances IFN-γ production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells, BLOOD, Vol: 113, Pages: 3485-3493, ISSN: 0006-4971
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- Citations: 53
Yoon I-H, Choi S-E, Kim Y-H, et al., 2008, Pancreatic Islets Induce CD4<SUP>+</SUP>CD25<SUP>-Foxp3+</SUP> T-Cell Regulated Tolerance to HY-Mismatched Skin Grafts, TRANSPLANTATION, Vol: 86, Pages: 1352-1360, ISSN: 0041-1337
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- Citations: 11
Greenlaw RE, Gardner NJ, Farrar CA, et al., 2008, An antibody combination that targets activated T cells extends graft survival in sensitized recipients, AMERICAN JOURNAL OF TRANSPLANTATION, Vol: 8, Pages: 2272-2282, ISSN: 1600-6135
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- Citations: 7
Baruah P, Dumitriu IE, Malik T, et al., 2008, C1q enhances IFN-γ production by antigen specific T cells via the CD40 co-stimulatory pathway on dendritic cells, 22nd International Complement Workshop, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 4105-4106, ISSN: 0161-5890
Brent L, Simpson E, 2008, On skin grafting in mice, TRANSPLANTATION, Vol: 85, Pages: 1362-1362, ISSN: 0041-1337
Chai J-G, Coe D, Chen D, et al., 2008, In vitro expansion improves in vivo regulation by CD4<SUP>+</SUP>CD25<SUP>+</SUP> regulatory T cells, JOURNAL OF IMMUNOLOGY, Vol: 180, Pages: 858-869, ISSN: 0022-1767
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- Citations: 53
Furmanski AL, Ferreira C, Bartok I, et al., 2008, Public T cell receptor β-chains are not advantaged during positive selection, JOURNAL OF IMMUNOLOGY, Vol: 180, Pages: 1029-1039, ISSN: 0022-1767
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- Citations: 23
Simpson E, 2008, Special regulatory T-cell review: regulation of immune responses - examining the role of T cells, IMMUNOLOGY, Vol: 123, Pages: 13-16, ISSN: 0019-2805
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- Citations: 18
CHANDLER P, FAIRCHILD S, SIMPSON E, 2007, H-Y RESPONSES OF NON-OBESE DIABETIC (NOD) MICE, JOURNAL OF IMMUNOGENETICS, Vol: 15, Pages: 321-330, ISSN: 0305-1811
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- Citations: 2
Robertson NJ, Chai J-G, Millrain M, et al., 2007, Natural regulation of immunity to minor histocompatibility antigens, JOURNAL OF IMMUNOLOGY, Vol: 178, Pages: 3558-3565, ISSN: 0022-1767
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- Citations: 20
Simpson E, 2006, A historical perspective on immunological privilege, IMMUNOLOGICAL REVIEWS, Vol: 213, Pages: 12-22, ISSN: 0105-2896
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- Citations: 64
Ferreira C, Furmanski A, Millrain M, et al., 2006, TCR-α CDR3 loop audition regulates positive selection, JOURNAL OF IMMUNOLOGY, Vol: 177, Pages: 2477-2485, ISSN: 0022-1767
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- Citations: 8
Palmowski MJ, Gileadi U, Salio M, et al., 2006, Role of immunoproteasomes in cross-presentation, JOURNAL OF IMMUNOLOGY, Vol: 177, Pages: 983-990, ISSN: 0022-1767
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- Citations: 64
Monk NJ, Hargreaves REG, Simpson E, et al., 2006, Transplant tolerance: models, concepts and facts, JOURNAL OF MOLECULAR MEDICINE-JMM, Vol: 84, Pages: 295-304, ISSN: 0946-2716
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- Citations: 13
Millrain M, Scott D, Addey C, et al., 2005, Identification of the immunodominant HYH2-D<SUP>k</SUP> epitope and evaluation of the role of direct and indirect antigen presentation in HY responses, JOURNAL OF IMMUNOLOGY, Vol: 175, Pages: 7209-7217, ISSN: 0022-1767
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- Citations: 24
Scott D, Dewchand H, Simpson E, et al., 2005, Transplantation tolerance induced by intranasal administration of HY peptides, IMMUNOLOGY, Vol: 116, Pages: 44-45, ISSN: 0019-2805
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