Imperial College London

ProfessorLizSimpson

Faculty of MedicineDepartment of Immunology and Inflammation

Senior Research Investigator
 
 
 
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Contact

 

+44 (0)20 3313 2315elizabeth.simpson

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

224 results found

Simpson E, Dazzi F, 2019, Bone Marrow Transplantation 1957-2019, Frontiers in Immunology, Vol: 10, ISSN: 1664-3224

Clinical bone marrow transplantation started in 1957 at a time when remarkably little was known about hematopoietic stems cells, immune responses to transplants or the identity of transplant antigens. This review will delineate the substantial increase in knowledge about these three areas gained between then and 1992 when the Ceppellini School course on Bone Marrow Transplantation was held, along with the progress made in clinical application, as well as the stumbling blocks that remained to be overcome by further research to advance knowledge. It will outline the significant progress made between 1992 and the present year, 2019, and the remaining problems.

Journal article

Simpson E, 2015, Medawar's legacy to cellular immunology and clinical transplantation: a commentary on Billingham, Brent and Medawar (1956) 'Quantitative studies on tissue transplantation immunity. III. Actively acquired tolerance', Philosophical Transactions of the Royal Society B: Biological Sciences, Vol: 370, ISSN: 1471-2970

‘Quantitative studies on tissue transplantation immunity. III. Actively acquired tolerance’, published in Philosophical Transactions B in 1956 by Peter Medawar and his colleagues, PhD graduate Leslie Brent and postdoctoral fellow Rupert Billingham, is a full description of the concept of acquired transplantation tolerance. Their 1953 Nature paper (Billingham RE et al. 1953 Nature 172, 603–606. (doi:10.1038/172603a0)) had provided initial evidence with experimental results from a small number of neonatal mice, with mention of similar findings in chicks. The Philosophical Transactions B 1956 paper is clothed with an astonishing amount of further experimental detail. It is written in Peter Medawar's landmark style: witty, perceptive and full of images that can be recalled even when details of the supporting information have faded. Those images are provided not just by a series of 20 colour plates showing skin graft recipient mice, rats, rabbits, chickens and duck, bearing fur or plumage of donor origin, but by his choice of metaphor, simile and analogy to express the questions being addressed and the interpretation of their results, along with those of relevant published data and his prescient ideas of what the results might portend. This work influenced both immunology researchers and clinicians and helped to lay the foundations for successful transplantation programmes. It led to the award of a Nobel prize in 1960 to Medawar, and subsequently to several scientists who advanced these areas. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society.

Journal article

Fossati-Jimack L, Ling GS, Baudino L, Szajna M, Manivannan K, Zhao JC, Midgley R, Chai J-G, Simpson E, Botto M, Scott Det al., 2015, Intranasal peptide-induced tolerance and linked suppression: consequences of complement deficiency, IMMUNOLOGY, Vol: 144, Pages: 149-157, ISSN: 0019-2805

Journal article

Baudino L, Sardini A, Ruseva MM, Fossati-Jimack L, Cook HT, Scott D, Simpson E, Botto Met al., 2014, C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens, Proceedings of the National Academy of Sciences of the United States of America, Vol: 111, Pages: 1503-1508, ISSN: 0027-8424

Journal article

Eljaafari A, Yuruker O, Ferrand C, Farre A, Addey C, Tartelin M-L, Thomas X, Tiberghien P, Simpson E, Rigal D, Scott Det al., 2013, Isolation of Human CD4/CD8 Double-Positive, Graft-Versus-Host Disease-Protective, Minor Histocompatibility Antigen-Specific Regulatory T Cells and of a Novel HLA-DR7-Restricted HY-Specific CD4 Clone, JOURNAL OF IMMUNOLOGY, Vol: 190, Pages: 184-194, ISSN: 0022-1767

Journal article

Moreau A, Noble A, Ratnasothy K, Chai J-G, Deltour L, Cuturi M-C, Simpson E, Lechler R, Lombardi Get al., 2012, Absence of Galectin-1 accelerates CD8(+) T cell-mediated graft rejection, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 42, Pages: 2881-2888, ISSN: 0014-2980

Journal article

Ling GS, Fossati-Jimack L, Szajna M, Tahir S, Cook HT, Scott D, Simpson E, Botto Met al., 2011, Intranasal tolerance induction is maintained in mice lacking CD11b but through different mechanisms, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 196-196, ISSN: 0019-2805

Conference paper

Simpson E, 2011, Examination of Ohno's Hypothesis with Anne McLaren: Separation of HY and TDY, 44th Annual Meeting of the Society-for-the-Study-of-Reproduction (SSR), Publisher: SOC STUDY REPRODUCTION, ISSN: 0006-3363

Conference paper

Manzo T, Michelini RH, Basso V, Freschi M, Schumacher T, Simpson E, Bellone M, Mondino Aet al., 2011, Non myeloablative allogeneic transplantation and tumor-specific vaccination promote eradication of advanced prostate cancer, 25th Conference on European Immunogenetics and Histocompatibility, Publisher: WILEY-BLACKWELL, Pages: 375-376, ISSN: 0001-2815

Conference paper

Manzo T, Michelini RH, Basso V, Ricupito A, Chai J-G, Simpson E, Bellone M, Mondino Aet al., 2011, Concurrent Allorecognition Has a Limited Impact on Posttransplant Vaccination, JOURNAL OF IMMUNOLOGY, Vol: 186, Pages: 1361-1368, ISSN: 0022-1767

Journal article

Coe D, Addey C, White M, Simpson E, Dyson J, Chai J-Get al., 2010, The roles of antigen-specificity, responsiveness to transforming growth factor-beta and antigen-presenting cell subsets in tumour-induced expansion of regulatory T cells, IMMUNOLOGY, Vol: 131, Pages: 556-569, ISSN: 0019-2805

Journal article

Manzo T, Michelini RH, Freschi M, Ponzoni M, Simpson E, Bellone M, Mondino Aet al., 2010, Allogeneic Transplantation and Tumor-Specific Vaccination Promote Infiltration and Eradication of Advanced Prostate Cancer, JOURNAL OF IMMUNOTHERAPY, Vol: 33, Pages: 902-903, ISSN: 1524-9557

Journal article

Baruah P, Simpson E, Dumitriu IE, Derbyshire K, Coe D, Addey C, Dyson J, Chai J-G, Cook T, Scott D, Botto Met al., 2010, Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 40, Pages: 1758-1767, ISSN: 0014-2980

Journal article

Michelini RH, Freschi M, Manzo T, Jachetti E, Degl'Innocenti E, Grioni M, Basso V, Bonini C, Simpson E, Mondino A, Bellone Met al., 2010, Concomitant Tumor and Minor Histocompatibility Antigen-Specific Immunity Initiate Rejection and Maintain Remission from Established Spontaneous Solid Tumors, CANCER RESEARCH, Vol: 70, Pages: 3505-3514, ISSN: 0008-5472

Journal article

Baruah P, Dumitriu IE, Malik TH, Cook HT, Dyson J, Scott D, Simpson E, Botto Met al., 2009, C1q enhances IFN-gamma production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells, BLOOD, Vol: 113, Pages: 3485-3493, ISSN: 0006-4971

Journal article

Yoon I-H, Choi S-E, Kim Y-H, Yang S-H, Park J-H, Park C-S, Kim Y, Kim J-S, Kim S-J, Simpson E, Park C-Get al., 2008, Pancreatic Islets Induce CD4(+)CD25(-Foxp3+) T-Cell Regulated Tolerance to HY-Mismatched Skin Grafts, TRANSPLANTATION, Vol: 86, Pages: 1352-1360, ISSN: 0041-1337

Journal article

Greenlaw RE, Gardner NJ, Farrar CA, Shariff H, Sacks SH, Yagita H, Simpson E, Jurcevic Set al., 2008, An antibody combination that targets activated T cells extends graft survival in sensitized recipients, AMERICAN JOURNAL OF TRANSPLANTATION, Vol: 8, Pages: 2272-2282, ISSN: 1600-6135

Journal article

Baruah P, Dumitriu IE, Malik T, Cook HT, Dyson J, Scott D, Simpson E, Botto Met al., 2008, C1q enhances IFN-gamma production by antigen specific T cells via the CD40 co-stimulatory pathway on dendritic cells, 22nd International Complement Workshop, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 4105-4106, ISSN: 0161-5890

Conference paper

Brent L, Simpson E, 2008, On skin grafting in mice, TRANSPLANTATION, Vol: 85, Pages: 1362-1362, ISSN: 0041-1337

Journal article

Chai J-G, Coe D, Chen D, Simpson E, Dyson J, Scott Det al., 2008, In vitro expansion improves in vivo regulation by CD4(+)CD25(+) regulatory T cells, JOURNAL OF IMMUNOLOGY, Vol: 180, Pages: 858-869, ISSN: 0022-1767

Journal article

Furmanski AL, Ferreira C, Bartok I, Dimakou S, Rice J, Stevenson FK, Millrain MM, Simpson E, Dyson Jet al., 2008, Public T cell receptor beta-chains are not advantaged during positive selection, JOURNAL OF IMMUNOLOGY, Vol: 180, Pages: 1029-1039, ISSN: 0022-1767

Journal article

Simpson E, 2008, Special regulatory T-cell review: regulation of immune responses - examining the role of T cells, IMMUNOLOGY, Vol: 123, Pages: 13-16, ISSN: 0019-2805

Journal article

Robertson NJ, Chai J-G, Millrain M, Scott D, Hashim F, Manktelow E, Lemonnier F, Simpson E, Dyson Jet al., 2007, Natural regulation of immunity to minor histocompatibility antigens, JOURNAL OF IMMUNOLOGY, Vol: 178, Pages: 3558-3565, ISSN: 0022-1767

Journal article

Simpson E, 2006, A historical perspective on immunological privilege, IMMUNOLOGICAL REVIEWS, Vol: 213, Pages: 12-22, ISSN: 0105-2896

Journal article

Ferreira C, Furmanski A, Millrain M, Bartok I, Guillaume P, Lees R, Simpson E, MacDonald HR, Dyson Jet al., 2006, TCR-alpha CDR3 loop audition regulates positive selection, JOURNAL OF IMMUNOLOGY, Vol: 177, Pages: 2477-2485, ISSN: 0022-1767

Journal article

Palmowski MJ, Gileadi U, Salio M, Gallimore A, Millrain M, James E, Addey C, Scott D, Dyson J, Simpson E, Cerundolo Vet al., 2006, Role of immunoproteasomes in cross-presentation, JOURNAL OF IMMUNOLOGY, Vol: 177, Pages: 983-990, ISSN: 0022-1767

Journal article

Monk NJ, Hargreaves REG, Simpson E, Dyson JP, Jurcevic Set al., 2006, Transplant tolerance: models, concepts and facts, JOURNAL OF MOLECULAR MEDICINE-JMM, Vol: 84, Pages: 295-304, ISSN: 0946-2716

Journal article

Scott D, Dewchand H, Simpson E, Chai JGet al., 2005, Transplantation tolerance induced by intranasal administration of HY peptides, IMMUNOLOGY, Vol: 116, Pages: 44-45, ISSN: 0019-2805

Journal article

Millrain M, Scott D, Addey C, Dewchand H, Ellis P, Ehrmann I, Mitchell M, Burgoyne P, Simpson E, Dyson Jet al., 2005, Identification of the immunodominant HYH2-D-k epitope and evaluation of the role of direct and indirect antigen presentation in HY responses, JOURNAL OF IMMUNOLOGY, Vol: 175, Pages: 7209-7217, ISSN: 0022-1767

Journal article

Choi EY, Jung KC, Park HJ, Chung DH, Song JS, Yang SD, Simpson E, Park SHet al., 2005, Thymocyte-thymocyte interaction for efficient positive selection and maturation of CD4 T cells, IMMUNITY, Vol: 23, Pages: 387-396, ISSN: 1074-7613

Journal article

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