I am Senior Lectuer in Genomic Medicine at Imperial College Faculty of Medicine and I lead the Integrative Genomics and Medicine Group of the MRC Institute of Clinical Sciences, which is based on the Hammersmith campus of Imperial College London (http://www.csc.mrc.ac.uk/Research/Groups/GMC/IntegrativeGenomicsMedicine/).
Our research focuses on the integration of genomic, phenotypic and genetic resources to identify risk factors and molecular networks for complex traits and disease.
Understanding how complex disease systems operate requires the integration of multiple layers of biological information from DNA to phenotype. In my group, we integrate informatics and multi-dimensional modelling of genomic data to elucidate the regulatory processes underlying complex traits, including metabolic, cardiovascular, inflammatory, neurological and behavioral phenotypes.
In particular, rather than focusing on single disease susceptibility genes, we explore pathways and networks to better predict the consequences of genetic and epigenetic variations on complex disease. We employ systems-genetics approaches, from model organisms to humans, to provide functional annotation of genes in biological processes and reveal the signal of common genetic variation of small effect that is not captured by typical genome wide association studies.
et al., 2019, Ethnicity-Specific Skeletal Muscle Transcriptional Signatures and Their Relevance to Insulin Resistance in Singapore., J Clin Endocrinol Metab, Vol:104, Pages:465-486
et al., 2019, Systems genetics identifies a macrophage cholesterol network associated with physiological wound healing, Jci Insight, Vol:4, ISSN:2379-3708
et al., 2018, Temporal dynamics of Wnt-dependent transcriptome reveal an oncogenic Wnt/MYC/ribosome axis, Journal of Clinical Investigation, Vol:128, ISSN:0021-9738, Pages:5620-5633
et al., 2018, Systems Genetics Approaches in Rat Identify Novel Genes and Gene Networks Associated With Cardiac Conduction, Journal of the American Heart Association, Vol:7, ISSN:2047-9980
et al., 2018, Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture, Nature Communications, Vol:9, ISSN:2041-1723