Imperial College London
Dr Enrique Martinez-Perez

DrEnriqueMartinez-Perez

Faculty of Medicine, Institute of Clinical Sciences

Reader in Chromosome Biology
 
 
 
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Contact

 

+44 (0)20 3313 4314enrique.martinez-perez Website

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Silva:2014:10.1016/j.devcel.2014.10.001,
author = {Silva, N and Ferrandiz, N and Barroso, C and Tognetti, S and Lightfoot, J and Telecan, O and Encheva, V and Faull, P and Hanni, S and Furger, A and Snijders, AP and Speck, C and Martinez-Perez, E},
doi = {10.1016/j.devcel.2014.10.001},
journal = {Developmental Cell},
pages = {503--511},
title = {The fidelity of synaptonemal complex assembly is regulated by a signaling mechanism that controls early meiotic progression},
url = {http://dx.doi.org/10.1016/j.devcel.2014.10.001},
volume = {31},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Proper chromosome segregation during meiosis requires the assembly of the synaptonemal complex (SC) between homologous chromosomes. However, the SC structure itself is indifferent to homology, andpoorly understood mechanisms that depend on conserved HORMA-domain proteins prevent ectopic SC assembly. Although HORMA-domain proteins are thought to regulate SC assembly as intrinsic components of meiotic chromosomes, here we uncover a key role for nuclear soluble HORMA-domain protein HTP-1 in the quality control of SC assembly. We show that a mutant form of HTP-1 impaired in chromosome loading provides functionality of an HTP-1-dependent checkpoint that delays exit from homology search-competent stages until all homolog pairs are linked by the SC. Bypassing of this regulatory mechanism results in premature meiotic progression and licensing of homology-independent SC assembly. These findings identify nuclear soluble HTP-1 as a regulator of early meiotic progression, suggesting parallels with the mode of action of Mad2 in the spindle assembly checkpoint.
AU  - Silva,N
AU  - Ferrandiz,N
AU  - Barroso,C
AU  - Tognetti,S
AU  - Lightfoot,J
AU  - Telecan,O
AU  - Encheva,V
AU  - Faull,P
AU  - Hanni,S
AU  - Furger,A
AU  - Snijders,AP
AU  - Speck,C
AU  - Martinez-Perez,E
DO  - 10.1016/j.devcel.2014.10.001
EP  - 511
PY  - 2014///
SN  - 1534-5807
SP  - 503
TI  - The fidelity of synaptonemal complex assembly is regulated by a signaling mechanism that controls early meiotic progression
T2  - Developmental Cell
UR  - http://dx.doi.org/10.1016/j.devcel.2014.10.001
UR  - http://hdl.handle.net/10044/1/27321
VL  - 31
ER  -
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