Imperial College London
Dr Enrique Martinez-Perez

DrEnriqueMartinez-Perez

Faculty of Medicine, Institute of Clinical Sciences

Reader in Chromosome Biology
 
 
 
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Contact

 

+44 (0)20 3313 4314enrique.martinez-perez Website

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Crawley:2016:10.7554/eLife.10851,
author = {Crawley, O and Barroso, C and Testori, S and Ferrandiz, N and Silva, N and Castellano-Pozo, M and Jaso-Tamame, AL and Martinez-Perez, E},
doi = {10.7554/eLife.10851},
journal = {eLife},
title = {Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes},
url = {http://dx.doi.org/10.7554/eLife.10851},
volume = {5},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Wapl induces cohesin dissociation from DNA throughout the mitotic cell cycle, modulating sister chromatid cohesion and higher-order chromatin structure. Cohesin complexes containing meiosis-specific kleisin subunits govern most aspects of meiotic chromosome function, but whether Wapl regulates these complexes remains unknown. We show that during C. elegans oogenesis WAPL-1 antagonizes binding of cohesin containing COH-3/4 kleisins, but not REC-8, demonstrating that sensitivity to WAPL-1 is dictated by kleisin identity. By restricting the amount of chromosome-associated COH-3/4 cohesin, WAPL-1 controls chromosome structure throughout meiotic prophase. In the absence of REC-8, WAPL-1 inhibits COH-3/4-mediated cohesion, which requires crossover-fated events formed during meiotic recombination. Thus, WAPL-1 promotes functional specialization of meiotic cohesin: WAPL-1-sensitive COH-3/4 complexes modulate higher-order chromosome structure, while WAPL-1-refractory REC-8 complexes provide stable cohesion. Surprisingly, a WAPL-1-independent mechanism removes cohesin before metaphase I. Our studies provide insight into how meiosis-specific cohesin complexes are regulated to ensure formation of euploid gametes.
AU  - Crawley,O
AU  - Barroso,C
AU  - Testori,S
AU  - Ferrandiz,N
AU  - Silva,N
AU  - Castellano-Pozo,M
AU  - Jaso-Tamame,AL
AU  - Martinez-Perez,E
DO  - 10.7554/eLife.10851
PY  - 2016///
SN  - 2050-084X
TI  - Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.10851
UR  - http://hdl.handle.net/10044/1/39797
VL  - 5
ER  -
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