Imperial College London
Dr Enrique Martinez-Perez

DrEnriqueMartinez-Perez

Faculty of Medicine, Institute of Clinical Sciences

Reader in Chromosome Biology
 
 
 
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Contact

 

+44 (0)20 3313 4314enrique.martinez-perez Website

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nadarajan:2016:10.7554/eLife.12039,
author = {Nadarajan, S and Mohideen, F and Tzur, YB and Ferrandiz, N and Crawley, O and Montoya, A and Faull, P and Snijders, AP and Cutillas, PR and Jambhekar, A and Blower, MD and Martinez-Perez, E and Herper, JW and Colaiacovo, MP},
doi = {10.7554/eLife.12039},
journal = {eLife},
pages = {1--26},
title = {The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis},
url = {http://dx.doi.org/10.7554/eLife.12039},
volume = {5},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Asymmetric disassembly of the synaptonemal complex (SC) is crucial for propermeiotic chromosome segregation. However, the signaling mechanisms that directly regulate thisprocess are poorly understood. Here we show that the mammalian Rho GEF homolog, ECT-2,functions through the conserved RAS/ERK MAP kinase signaling pathway in the C. elegansgermline to regulate the disassembly of SC proteins. We find that SYP-2, a SC central regioncomponent, is a potential target for MPK-1-mediated phosphorylation and that constitutivelyphosphorylated SYP-2 impairs the disassembly of SC proteins from chromosomal domains referredto as the long arms of the bivalents. Inactivation of MAP kinase at late pachytene is critical fortimely disassembly of the SC proteins from the long arms, and is dependent on the crossover (CO)promoting factors ZHP-3/RNF212/Zip3 and COSA-1/CNTD1. We propose that the conserved MAPkinase pathway coordinates CO designation with the disassembly of SC proteins to ensure accuratechromosome segregation.
AU  - Nadarajan,S
AU  - Mohideen,F
AU  - Tzur,YB
AU  - Ferrandiz,N
AU  - Crawley,O
AU  - Montoya,A
AU  - Faull,P
AU  - Snijders,AP
AU  - Cutillas,PR
AU  - Jambhekar,A
AU  - Blower,MD
AU  - Martinez-Perez,E
AU  - Herper,JW
AU  - Colaiacovo,MP
DO  - 10.7554/eLife.12039
EP  - 26
PY  - 2016///
SN  - 2050-084X
SP  - 1
TI  - The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.12039
UR  - https://elifesciences.org/articles/12039
UR  - http://hdl.handle.net/10044/1/56358
VL  - 5
ER  -
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