Imperial College London

ProfessorEricAboagye

Faculty of MedicineDepartment of Surgery & Cancer

Professor
 
 
 
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Contact

 

+44 (0)20 3313 3759eric.aboagye

 
 
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Assistant

 

Mrs Maureen Francis +44 (0)20 7594 2793

 
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Location

 

GN1Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

332 results found

Aboagye EO, Mori N, Bhujwalla ZM, 2001, Effect of malignant transformation on lactate levels of human mammary epithelial cells, ADVANCES IN ENZYME REGULATION, VOL 41, Vol: 41, Pages: 251-260, ISSN: 0065-2571

Journal article

Brown GD, Osman S, Wilson HK, Aboagye E, Price PM, Luthra SK, Brady Fet al., 2001, Metabolism of [11c-Methyl]choline in tumour bearing mice and synthesis and isolation of its catabolite [11c-Methyl]betaine, J Label Compounds Radiopharm, ISSN: 0362-4803

Journal article

Bhujwalla ZM, Artemov D, Aboagye E, Ackerstaff E, Gillies RJ, Natarajan K, Solaiyappan Met al., 2001, The physiological environment in cancer vascularization, invasion and metastasis., Novartis Found Symp, Vol: 240, Pages: 23-38, ISSN: 1528-2511

One of the most lethal aspects of cancer arises from its ability to invade and metastasize. Determining the factors that promote cancer cell invasion and metastasis is therefore critically important in treating this disease. The tumour physiological environment is uniquely different from normal tissue, and exhibits hypoxia, acidic extracellular pH and high levels of lactate. This environment, dictated largely by abnormal tumour vasculature and metabolism, in turn also promotes angiogenesis. The physiological environment, tumour metabolism, angiogenesis and vascularization are therefore inextricably linked. We have developed and applied non-invasive magnetic resonance (MR) imaging (I) and spectroscopy (S) techniques to understand the role of vascular, physiological and metabolic properties in cancer invasion and metastasis. These MR studies are performed with human breast and prostate cancer cells maintained in culture or grown as solid tumours in immune-suppressed mice. We have detected significant differences in vascular, physiological and metabolic characteristics of metastatic and non-metastatic human breast and prostate cancer models with MRI and MRS. Using a combined MRI/MRS approach we are currently acquiring metabolic, extracellular pH and vascular images from the same localized regions within a solid tumour to further understand the dynamics between these parameters and their role in cancer invasion and metastasis.

Journal article

Brown GD, Wilson HK, Westwell AD, Hutchinson I, Stevens MFG, Price PM, Aboagye E, Brady F, Luthra SKet al., 2001, Radiolabelling of the potential anti-cancer agent 5-Fluoro-2-(4-amino-3-methylphenyl)benzothiazole (5F203) with fluorine-18, J Label Compounds Radiopharm, ISSN: 0362-4803

Journal article

Khanum N, Luthra SK, Zhao Y, Aboagye E, Price PM, Burke P, Brady Fet al., 2001, Carbon-11 labelling of a half mustard prodrug by reductive alkylation using [11C]acetaldehyde. A potential tracer for evolution of ADEPT or GDEPT using PET, J Label Compounds Radiopharm, ISSN: 0362-4803

Journal article

Glaser M, Collingridge DR, Aboagye E, Bouchier-Hayes L, Brown DJ, Hutchinson OC, Martin S, Price PM, Luthra SK, Brady Fet al., 2001, Preparation of [124I]IBA-Annexin-v as a potential PET probe for apoptosis, J Label Compounds Radiopharm, ISSN: 0362-4803

Journal article

Saleem A, Yap J, Osman S, Brady F, Suttle B, Lucas SV, Jones T, Price PM, Aboagye EOet al., 2000, Modulation of fluorouracil tissue pharmacokinetics by eniluracil: in-vivo imaging of drug action, LANCET, Vol: 355, Pages: 2125-2131, ISSN: 0140-6736

Journal article

Saleem A, Aboagye EO, Price PM, 2000, In vivo monitoring of drugs using radiotracer techniques, ADVANCED DRUG DELIVERY REVIEWS, Vol: 41, Pages: 21-39, ISSN: 0169-409X

Journal article

Natarajan K, Mori N, Artemov D, Aboagye EO, Chacko VP, Bhujwalla ZMet al., 2000, Phospholipid profiles of invasive human breast cancer cells are altered towards a less invasive phospholipid profile by the anti-inflammatory agent indomethacin, ADVANCES IN ENZYME REGULATION, VOL 40, Vol: 40, Pages: 271-284, ISSN: 0065-2571

Journal article

Aboagye EO, 1999, Cancer Research Campaign's (CRC) program of in vivo pharmacokinetics and pharmacodynamics in drug development using positron emission tomography., CLINICAL CANCER RESEARCH, Vol: 5, Pages: 3871S-3872S, ISSN: 1078-0432

Journal article

Bhujwalla ZM, Aboagye EO, Gillies RJ, Chacko VP, Mendola CE, Backer JMet al., 1999, Nm23-transfected MDA-MB-435 human breast carcinoma cells form tumors with altered phospholipid metabolism and pH: A <sup>31</sup>P nuclear magnetic resonance study in vivo and vitro, Magnetic Resonance in Medicine, Vol: 41, Pages: 897-903, ISSN: 0740-3194

Nm23 genes are involved in the control of the metastatic potential of breast carcinoma cells. To understand the impact of nm23 genes on tumor physiology and metabolism, a 31P nuclear magnetic resonance (NMR) spectroscopic study was performed on tumors formed in the mammary fat pad of severe combined immunodeficiency mice by MDA-MB-3435 human breast carcinoma cells transfected with cDNA encoding wild type nm23-H1 and nm23-H2 proteins. Tumors formed by MDA-MB-435 cells transfected with vector alone were used as controls. All transgene tumors exhibited significantly higher levels of phosphodiester (PDE) compounds relative to phosphomonoester (PME) compounds in vivo compared with control tumors. Similar differences in PDE and PME also were observed for spectra obtained from cells growing in culture. Intracellular pH was significantly lower and extracellular pH was significantly higher for transgene tumors compared with control tumors. Histologic analysis of lung sections confirmed reductions in incidence, number, and size of metastatic nodules for animals bearing transgene tumors. These results suggest that nm23 genes may affect suppression of metastasis through phospholipid-mediated signaling and cellular pH regulation.

Journal article

Bhujwalla ZM, Aboagye EO, Gillies RJ, Chacko VP, Mendola CE, Backer JMet al., 1999, Nm23-transfected MDA-MB-435 human breast carcinoma cells form tumors with altered phospholipid metabolism and pH: A P-31 nuclear magnetic resonance study in vivo and in vitro, MAGNETIC RESONANCE IN MEDICINE, Vol: 41, Pages: 897-903, ISSN: 0740-3194

Journal article

Aboagye EO, Bhujwalla ZM, 1999, Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells, CANCER RESEARCH, Vol: 59, Pages: 80-84, ISSN: 0008-5472

Journal article

Aboagye EO, Kelson AB, Tracy M, Workman Pet al., 1998, Erratum: Preclinical development and current status of the fluorinated 2-nitroimidazole hypoxia probe N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR 4554, CRC 94/17): A non-invasive diagnostic probe for the measurement of tumor hypoxia by magnetic resonance spectroscopy and imaging, and by positron emission tomography (Anti-Cancer Drug Design (1998) (703-730)), Anti-Cancer Drug Design, Vol: 13, Pages: 1009-1010, ISSN: 0266-9536

Journal article

Aboagye EO, Kelson AB, Tracy M, Workman Pet al., 1998, Preclinical development and current status of the fluorinated 2-nitroimidazole hypoxia probe N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR 4554, CRC 94/17): a non-invasive diagnostic probe for the measurement of tumor hypoxia by magnetic resonance spectroscopy and imaging, and by positron emission tomography (vol 13, pg 703, 1998), ANTI-CANCER DRUG DESIGN, Vol: 13, Pages: 1009-1010, ISSN: 0266-9536

Journal article

Aboagye EO, Dillehay LE, Bhujwalla ZM, Lee DJet al., 1998, Hypoxic cell cytotoxin tirapazamine induces acute changes in tumor energy metabolism and pH: A <sup>31</sup>P magnetic resonance spectroscopy study, Radiation Oncology Investigations, Vol: 6, Pages: 249-254, ISSN: 1065-7541

Tirapazamine is a hypoxic cell cytotoxin in phase II/III trials. To further understand its mechanism of action in vivo, we examined the effect of tirapazamine on tumor energy metabolism and pH. RIF-1 and SCCVII tumors were grown subcutaneously in the flanks of C3H mice. Tumor energy metabolism, expressed as the ratio of inorganic phosphate to nucleotide triphosphate (Pi/NTP), and intracellular pH (pHi), were measured by 31P magnetic resonance spectroscopy (MRS). In RIF-1 and SCCVII tumors, tirapazamine increased the Pi/NTP ratio by 2.6-fold and 3-fold, respectively, within the first hour after an intraperitoneal dose of 0.3 mmol/kg. A corresponding decrease in pHi from 7.05 ± 0.07 to 6.48 ± 0.06, and 7.21 ± 0.09 to 6.45 ± 0.02 in RIF-1 and SCCVII tumors, respectively, was observed. The decrease in tumor 31P bioenergetics and pH was reversible, as exemplified by RIF-1 tumors, which showed a further increase in Pi/NTP ratio of 3.5-fold by 5-8 hr, returning to normal range at 24 hr. Corresponding pHi of RIF-1 tumors was 6.88 ± 0.05 at 5-8 hr and 7.16 ± 0.05 at 24 hr. We concluded that tirapazamine induces acute changes in tumor energy metabolism and pHi. These findings are relevant to the rational selection and optimal timing of coadministered therapy. © 1998 Wiley-Liss, Inc.

Journal article

Aboagye EO, Artemov D, Senter PD, Bhujwalla ZMet al., 1998, Intratumoral conversion of 5-fluorocytosine to 5-fluorouracil by monoclonal antibody cytosine deaminase conjugates: Noninvasive detection of prodrug activation by magnetic resonance spectroscopy and spectroscopic imaging, CANCER RESEARCH, Vol: 58, Pages: 4075-4078, ISSN: 0008-5472

Journal article

Aboagye EO, Kelson AB, Tracy M, Workman Pet al., 1998, Preclinical development and current status of the fluorinated 2-nitroimidazole hypoxia probe N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR 4554, CRC 94/17): a non-invasive diagnostic probe for the measurement of tumor hypoxia by magnetic resonance spectroscopy and imaging, and by positron emission tomography, ANTI-CANCER DRUG DESIGN, Vol: 13, Pages: 703-730, ISSN: 0266-9536

Journal article

Aboagye EO, Bhujwalla ZM, Shungu DC, Glickson JDet al., 1998, Detection of tumor response to chemotherapy by H-1 nuclear magnetic resonance spectroscopy: Effect of 5-fluorouracil on lactate levels in radiation-inducted fibrosarcoma 1 tumors (vol 58, pg 1063, 1998), CANCER RESEARCH, Vol: 58, Pages: 2904-2904, ISSN: 0008-5472

Journal article

Aboagye EO, Bhujwalla ZM, He QH, Glickson JDet al., 1998, Evaluation of lactate as a H-1 nuclear magnetic resonance spectroscopy index for noninvasive prediction and early detection of tumor response to radiation therapy in EMT6 tumors, RADIATION RESEARCH, Vol: 150, Pages: 38-42, ISSN: 0033-7587

Journal article

McSheehy PMJ, Robinson SP, Ojugo ASE, Aboagye EO, Cannell MB, Leach MO, Judson IR, Griffiths JRet al., 1998, Carbogen breathing increases 5-fluorouracil uptake and cytotoxicity in hypoxic murine RIF-1 tumors: A magnetic resonance study in vivo, CANCER RESEARCH, Vol: 58, Pages: 1185-1194, ISSN: 0008-5472

Journal article

Aboagye EO, Bhujwalla ZM, Shungu DC, Glickson JDet al., 1998, Detection of tumor response to chemotherapy by H-1 nuclear magnetic resonance spectroscopy: Effect of 5-fluorouracil on lactate levels in radiation-induced fibrosarcoma 1 tumors, CANCER RESEARCH, Vol: 58, Pages: 1063-1067, ISSN: 0008-5472

Journal article

Aboagye EO, Maxwell RJ, Horsman MR, Lewis AD, Workman P, Tracy M, Griffiths JRet al., 1998, The relationship between tumour oxygenation determined by oxygen electrode measurements and magnetic resonance spectroscopy of the fluorinated 2-nitroimidazole SR-4554, BRITISH JOURNAL OF CANCER, Vol: 77, Pages: 65-70, ISSN: 0007-0920

Journal article

Aboagye EO, Dillehay LE, Bhujwalla ZM, Lee DJet al., 1998, Hypoxic cell cytotoxin tirapazamine induces acute changes in tumor energy metabolism and pH: a 31P magnetic resonance spectroscopy study., Radiat Oncol Investig, Vol: 6, Pages: 249-254, ISSN: 1065-7541

Tirapazamine is a hypoxic cell cytotoxin in phase II/III trials. To further understand its mechanism of action in vivo, we examined the effect of tirapazamine on tumor energy metabolism and pH. RIF-1 and SCCVII tumors were grown subcutaneously in the flanks of C3H mice. Tumor energy metabolism, expressed as the ratio of inorganic phosphate to nucleotide triphosphate (Pi/NTP), and intracellular pH (pHi), were measured by 31P magnetic resonance spectroscopy (MRS). In RIF-1 and SCCVII tumors, tirapazamine increased the Pi/NTP ratio by 2.6-fold and 3-fold, respectively, within the first hour after an intraperitoneal dose of 0.3 mmol/kg. A corresponding decrease in pHi from 7.05+/-0.07 to 6.48+/-0.06, and 7.21+/-0.09 to 6.45+/-0.02 in RIF-1 and SCCVII tumors, respectively, was observed. The decrease in tumor 31P bioenergetics and pH was reversible, as exemplified by RIF-1 tumors, which showed a further increase in Pi/NTP ratio of 3.5-fold by 5-8 hr, returning to normal range at 24 hr. Corresponding pHi of RIF-1 tumors was 6.88+/-0.05 at 5-8 hr and 7.16+/-0.05 at 24 hr. We concluded that tirapazamine induces acute changes in tumor energy metabolism and pHi. These findings are relevant to the rational selection and optimal timing of coadministered therapy.

Journal article

Aboagye EO, Lewis AD, Tracy M, Workman Pet al., 1997, Bioreductive metabolism of the novel fluorinated 2-nitroimidazole hypoxia probe N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitroimidazolyl) acetamide (SR-4554), BIOCHEMICAL PHARMACOLOGY, Vol: 54, Pages: 1217-1224, ISSN: 0006-2952

Journal article

Aboagye EO, Maxwell RJ, Kelson AB, Tracy M, Lewis AD, Graham MA, Horsman MR, Griffiths JR, Workman Pet al., 1997, Preclinical evaluation of the fluorinated 2-nitroimidazole N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR-4554) as a probe for the measurement of tumor hypoxia, CANCER RESEARCH, Vol: 57, Pages: 3314-3318, ISSN: 0008-5472

Journal article

McCoy CL, McIntyre DJO, Robinson SP, Aboagye EO, Griffiths JRet al., 1996, Magnetic resonance spectroscopy and imaging methods for measuring tumour and tissue oxygenation, BRITISH JOURNAL OF CANCER, Vol: 74, Pages: S226-S231, ISSN: 0007-0920

Journal article

Aboagye EO, Lewis AD, Graham MA, Tracy M, Kelson AB, Ryan KJ, Workman Pet al., 1996, The pharmacokinetics, bioavailability and biodistribution in mice of a rationally designed 2-nitroimidazole hypoxia probe SR-4554, ANTI-CANCER DRUG DESIGN, Vol: 11, Pages: 231-242, ISSN: 0266-9536

Journal article

McCoy CL, McIntyre DJO, Robinson SP, Aboagye EO, Griffiths JRet al., 1996, Magnetic resonance spectroscopy and imaging methods for measuring tumour and tissue oxygenation, ISSN: 0007-0920

It is well known that low levels of tissue oxygen (pO2) protect tumour cells from ionising radiation and some chemotherapeutic agents. Thus, numerous studies have been aimed at developing methods to measure tissue oxygenation. An initial discussion of some of the traditional methods for measuring oxygenation is included, followed by a discussion of magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) methods for measuring tumour and normal tissue oxygenation. The latter methods are of interest because of the non-invasive nature of magnetic resonance (MR). Some of the MR methods described herein include: 31P MRS, 1H MRS and MRI, and 19F MRS and MRI. Each method is detailed, including a brief assessment of its ability to measure tumour oxygenation and its potential for clinical application.

Conference paper

Aboagye EO, Tracy M, Kelson A, Workman P, Lewis Aet al., 1996, WO96/04249: Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells

Patent

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