Imperial College London

ProfessorEricAboagye

Faculty of MedicineDepartment of Surgery & Cancer

Professor
 
 
 
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Contact

 

+44 (0)20 3313 3759eric.aboagye

 
 
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Assistant

 

Mrs Maureen Francis +44 (0)20 7594 2793

 
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Location

 

GN1Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

351 results found

Collingridge DR, Carroll VA, Glaser M, Aboagye EO, Osman S, Hutchinson OC, Barthel H, Luthra SK, Brady F, Bicknell R, Price P, Harris ALet al., 2002, The development of [I-124]iodinated-VG76e: A novel tracer for imaging vascular endothelial growth factor in vivo using positron emission tomography, CANCER RESEARCH, Vol: 62, Pages: 5912-5919, ISSN: 0008-5472

Journal article

Liu D, Hutchinson OC, Osman S, Price P, Workman P, Aboagye EOet al., 2002, Use of radiolabelled choline as a pharmacodynamic marker for the signal transduction inhibitor geldanamycin, British Journal of Cancer, Vol: 87, Pages: 783-789, ISSN: 0007-0920

There is an urgent need to develop non-invasive pharmacodynamic endpoints for the evaluation of new molecular therapeutics that inhibit signal transduction. We hypothesised that, when labelled appropriately, changes in choline kinetics could be used to assess geldanamycin pharmacodynamics, which involves inhibition of the HSP90 molecular chaperone→Raf1→Mitogenic Extracellular Kinase→Extracellular Signal-Regulated Kinase 1 and 2 signal transduction pathway. Towards identifying a potential pharmacodynamic marker response, we have studied radiolabelled choline metabolism in HT29 human colon carcinoma cells following treatment with geldanamycin. We studied the effects of geldanamycin, on net cellular accumulation of (methyl-14C)choline and (methyl-14C)phosphocholine production. In parallel experiments, the effects of geldanamycin on extracellular signal-regulated kinase 1 and 2 phosphorylation and cell viability were also assessed. Additional validation studies were carried out with the mitogenic extracellular kinase inhibitor U0126 as a positive control; a cyclin-dependent kinase-2 inhibitor roscovitine and the phosphatidylinositol 3-kinase inhibitor LY294002 as negative controls. Hemicholinium-3, an inhibitor of choline transport and choline kinase activity was included as an additional control. In exponentially growing HT29 cells, geldanamycin inhibited extracellular signal-regulated kinase 1 and 2 phosphorylation in a concentration- and time-dependent manner. These changes were associated with a reduction in (methyl-14C)choline uptake, (methyl-14C) phosphocholine production and cell viability. Brief exposure to U0126, suppressed phosphocholine production to the same extent as Hemicholinium-3. In contrast to geldanamycin and U0126, which act upstream of extracellular signal-regulated kinase 1 and 2, roscovitine and LY294002 failed to suppress phosphocholine production. Our results suggest that when labelled with carbon-11 isotope, (methyl-11C)choline m

Journal article

Groot-Wassink T, Aboagye EO, Glaser M, Lemoine NR, Vassaux Get al., 2002, Adenovirus biodistribution and noninvasive imaging of gene expression in vivo by positron emission tomography using human sodium/iodide symporter as reporter gene, HUMAN GENE THERAPY, Vol: 13, Pages: 1723-1735, ISSN: 1043-0342

Journal article

Aboagye E, 2002, The use of imaging to accelerate drug development, DRUG DISCOVERY TODAY, Vol: 7, Pages: 706-707, ISSN: 1359-6446

Journal article

Yau K, Price P, Aboagye EO, 2002, Detection of thymidylate synthase (TS) inhibition, BRITISH JOURNAL OF CANCER, Vol: 86, Pages: S110-S110, ISSN: 0007-0920

Journal article

Barthel H, Brown G, Wilson H, Collingridge DR, Price PM, Aboagye EOet al., 2002, In vivo evaluation of [F-18]fluoroetanidazole for imaging tumour hypoxia with positron emission tomography (PET), BRITISH JOURNAL OF CANCER, Vol: 86, Pages: S13-S13, ISSN: 0007-0920

Journal article

Gupta N, Saleem A, Osman S, Hoskin P, Price PM, Aboagye EOet al., 2002, Carbogen and nicotinamide selectively increase chemotherapy delivery and blood flow to liver metastasis, BRITISH JOURNAL OF CANCER, Vol: 86, Pages: S14-S14, ISSN: 0007-0920

Journal article

Barthel H, Cleji MC, Collingridge DR, Osman S, Brady F, Luthra SK, Price PM, Aboagye EOet al., 2002, In vivo evaluation of F-18-FLT for monitoring drug-induced modulation of tumor proliferation with positron emission tomography., JOURNAL OF NUCLEAR MEDICINE, Vol: 43, Pages: 27P-27P, ISSN: 0161-5505

Journal article

Aboagye EO, Luthra SK, Brady F, Poole K, Anderson H, Jones T, Boobis A, Burtles SSet al., 2002, Cancer Research UK procedures in manufacture and toxicology of radiotracers intended for Pre-phase I positron emission tomography studies in cancer patients, BRITISH JOURNAL OF CANCER, Vol: 86, Pages: 1052-1056, ISSN: 0007-0920

Journal article

Glaser M, Carroll VA, Collingridge DR, Aboagye E, Price P, Bicknell R, Harris AL, Luthra SK, Brady Fet al., 2002, Preparation of the iodine-124 derivative of the Bolton-Hunter reagent ({124l}l-SHPP) and its use for labelling a VEGF antibody as a PET tracer, J Labelled Comp Radiopharm, Vol: 45, Pages: 1077-1090, ISSN: 1099-1344

Journal article

Aboagye EO, Saleem A, Price PM, Aboagye EO, Saleem A, Price PMet al., 2002, Tumor imaging applicatons in the testing of new drugs, Anticancer drug development, Editors: Kerr, Publisher: Academic Pr, Pages: 353-369, ISBN: 9780120726516

TUMOR IMAGING APPLICATIONS IN THE TESTING OF NEW DRUGS Eric Ofori Aboagye Azeem Saleem Patricia M. Price Cancer Research Campaign PET Oncology Group ...

Book chapter

Brady F, Luthra SK, Brown GD, Osman S, Aboagye E, Saleem A, Price PMet al., 2001, Radiolabelled tracers and anticancer drugs for assessment of therapeutic efficacy using PET, CURRENT PHARMACEUTICAL DESIGN, Vol: 7, Pages: 1863-1892, ISSN: 1381-6128

Journal article

Aboagye EO, Saleem A, Cunningham VJ, Osman S, Price PMet al., 2001, Extraction of 5-Fluorouracil by tumor and liver: A noninvasive positron emission tomography study of patients with gastrointestinal cancer, CANCER RESEARCH, Vol: 61, Pages: 4937-4941, ISSN: 0008-5472

Journal article

Hutchinson OC, Liu D, Osman S, Price P, Workman P, Aboagye EOet al., 2001, Use of C-14 methyl choline to monitor inhibition of the extracellular signal-regulated kinase cascade: A novel approach towards imaging of signal-transduction inhibition, BRITISH JOURNAL OF CANCER, Vol: 85, Pages: 89-89, ISSN: 0007-0920

Journal article

Aboagye EO, 2001, Development of molecular imaging paradigms, BRITISH JOURNAL OF CANCER, Vol: 85, Pages: 14-14, ISSN: 0007-0920

Journal article

Pilatus U, Aboagye E, Artemov D, Mori N, Ackerstaff E, Bhujwalla ZMet al., 2001, Real-time measurements of cellular oxygen consumption, pH, and energy metabolism using nuclear magnetic resonance spectroscopy, MAGNETIC RESONANCE IN MEDICINE, Vol: 45, Pages: 749-755, ISSN: 0740-3194

Journal article

Osman S, Rowlinson-Busza G, Luthra SK, Aboagye EO, Brown GD, Brady F, Myers R, Gamage SA, Denny WA, Baguley BC, Price PMet al., 2001, Comparative biodistribution and metabolism of carbon-11-labeled N-[2-(dimethylamino)ethyl]acridine-4-carboxamide and DNA-intercalating analogues, CANCER RESEARCH, Vol: 61, Pages: 2935-2944, ISSN: 0008-5472

Journal article

Aboagye EO, Price PM, Jones T, 2001, In vivo pharmacokinetics and pharmacodynamics in drug development using positron-emission tomography, DRUG DISCOVERY TODAY, Vol: 6, Pages: 293-302, ISSN: 1359-6446

Journal article

Saleem A, Harte RJ, Matthews JC, Osman S, Brady F, Luthra SK, Brown GD, Bleehen N, Conners T, Jones T, Price PM, Aboagye EOet al., 2001, Pharmacokinetic evaluation of N-[2(dimethylamino)ethyl]acridine-4-carboxamide in patients by positron emission tomography, JOURNAL OF CLINICAL ONCOLOGY, Vol: 19, Pages: 1421-1429, ISSN: 0732-183X

Journal article

Aboagye EO, Mori N, Bhujwalla ZM, 2001, Effect of malignant transformation on lactate levels of human mammary epithelial cells, ADVANCES IN ENZYME REGULATION, VOL 41, Vol: 41, Pages: 251-260, ISSN: 0065-2571

Journal article

Glaser M, Collingridge DR, Aboagye E, Bouchier-Hayes L, Brown DJ, Hutchinson OC, Martin S, Price PM, Luthra SK, Brady Fet al., 2001, Preparation of [124I]IBA-Annexin-v as a potential PET probe for apoptosis, J Label Compounds Radiopharm, ISSN: 0362-4803

Journal article

Brown GD, Wilson HK, Westwell AD, Hutchinson I, Stevens MFG, Price PM, Aboagye E, Brady F, Luthra SK, Brown GD, Wilson HK, Westwell AD, Hutchinson I, Stevens MFG, Price PM, Aboagye E, Brady F, Luthra SKet al., 2001, Radiolabelling of the potential anti-cancer agent 5-Fluoro-2-(4-amino-3-methylphenyl)benzothiazole (5F203) with fluorine-18, J Label Compounds Radiopharm, ISSN: 0362-4803

Journal article

Khanum N, Luthra SK, Zhao Y, Aboagye E, Price PM, Burke P, Brady Fet al., 2001, Carbon-11 labelling of a half mustard prodrug by reductive alkylation using [11C]acetaldehyde. A potential tracer for evolution of ADEPT or GDEPT using PET, J Label Compounds Radiopharm, ISSN: 0362-4803

Journal article

Brown GD, Osman S, Wilson HK, Aboagye E, Price PM, Luthra SK, Brady F, Brown GD, Osman S, Wilson HK, Aboagye E, Price PM, Luthra SK, Brady Fet al., 2001, Metabolism of [11c-Methyl]choline in tumour bearing mice and synthesis and isolation of its catabolite [11c-Methyl]betaine, J Label Compounds Radiopharm, ISSN: 0362-4803

Journal article

Bhujwalla ZM, Artemov D, Aboagye E, Ackerstaff E, Gillies RJ, Natarajan K, Solaiyappan Met al., 2001, The physiological environment in cancer vascularization, invasion and metastasis., Novartis Found Symp, Vol: 240, Pages: 23-38, ISSN: 1528-2511

One of the most lethal aspects of cancer arises from its ability to invade and metastasize. Determining the factors that promote cancer cell invasion and metastasis is therefore critically important in treating this disease. The tumour physiological environment is uniquely different from normal tissue, and exhibits hypoxia, acidic extracellular pH and high levels of lactate. This environment, dictated largely by abnormal tumour vasculature and metabolism, in turn also promotes angiogenesis. The physiological environment, tumour metabolism, angiogenesis and vascularization are therefore inextricably linked. We have developed and applied non-invasive magnetic resonance (MR) imaging (I) and spectroscopy (S) techniques to understand the role of vascular, physiological and metabolic properties in cancer invasion and metastasis. These MR studies are performed with human breast and prostate cancer cells maintained in culture or grown as solid tumours in immune-suppressed mice. We have detected significant differences in vascular, physiological and metabolic characteristics of metastatic and non-metastatic human breast and prostate cancer models with MRI and MRS. Using a combined MRI/MRS approach we are currently acquiring metabolic, extracellular pH and vascular images from the same localized regions within a solid tumour to further understand the dynamics between these parameters and their role in cancer invasion and metastasis.

Journal article

Saleem A, Yap J, Osman S, Brady F, Suttle B, Lucas SV, Jones T, Price PM, Aboagye EOet al., 2000, Modulation of fluorouracil tissue pharmacokinetics by eniluracil: in-vivo imaging of drug action, LANCET, Vol: 355, Pages: 2125-2131, ISSN: 0140-6736

Journal article

Saleem A, Aboagye EO, Price PM, 2000, In vivo monitoring of drugs using radiotracer techniques, ADVANCED DRUG DELIVERY REVIEWS, Vol: 41, Pages: 21-39, ISSN: 0169-409X

Journal article

Natarajan K, Mori N, Artemov D, Aboagye EO, Chacko VP, Bhujwalla ZMet al., 2000, Phospholipid profiles of invasive human breast cancer cells are altered towards a less invasive phospholipid profile by the anti-inflammatory agent indomethacin, ADVANCES IN ENZYME REGULATION, VOL 40, Vol: 40, Pages: 271-284, ISSN: 0065-2571

Journal article

Aboagye EO, 1999, Cancer Research Campaign's (CRC) program of in vivo pharmacokinetics and pharmacodynamics in drug development using positron emission tomography., CLINICAL CANCER RESEARCH, Vol: 5, Pages: 3871S-3872S, ISSN: 1078-0432

Journal article

Bhujwalla ZM, Aboagye EO, Gillies RJ, Chacko VP, Mendola CE, Backer JMet al., 1999, Nm23-transfected MDA-MB-435 human breast carcinoma cells form tumors with altered phospholipid metabolism and pH: A <sup>31</sup>P nuclear magnetic resonance study in vivo and vitro, Magnetic Resonance in Medicine, Vol: 41, Pages: 897-903, ISSN: 0740-3194

Nm23 genes are involved in the control of the metastatic potential of breast carcinoma cells. To understand the impact of nm23 genes on tumor physiology and metabolism, a 31P nuclear magnetic resonance (NMR) spectroscopic study was performed on tumors formed in the mammary fat pad of severe combined immunodeficiency mice by MDA-MB-3435 human breast carcinoma cells transfected with cDNA encoding wild type nm23-H1 and nm23-H2 proteins. Tumors formed by MDA-MB-435 cells transfected with vector alone were used as controls. All transgene tumors exhibited significantly higher levels of phosphodiester (PDE) compounds relative to phosphomonoester (PME) compounds in vivo compared with control tumors. Similar differences in PDE and PME also were observed for spectra obtained from cells growing in culture. Intracellular pH was significantly lower and extracellular pH was significantly higher for transgene tumors compared with control tumors. Histologic analysis of lung sections confirmed reductions in incidence, number, and size of metastatic nodules for animals bearing transgene tumors. These results suggest that nm23 genes may affect suppression of metastasis through phospholipid-mediated signaling and cellular pH regulation.

Journal article

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