Imperial College London

ProfessorEricAboagye

Faculty of MedicineDepartment of Surgery & Cancer

Professor
 
 
 
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Contact

 

+44 (0)20 3313 3759eric.aboagye

 
 
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Assistant

 

Mrs Maureen Francis +44 (0)20 7594 2793

 
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Location

 

GN1Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

332 results found

Hoyng LL, Frings V, Hoekstra OS, Kenny LM, Aboagye EO, Boellaard Ret al., 2015, Metabolically active tumour volume segmentation from dynamic [F-18] FLT PET studies in non-small cell lung cancer, EJNMMI RESEARCH, Vol: 5, ISSN: 2191-219X

Journal article

Alam IS, Arshad MA, Quang-De N, Aboagye EOet al., 2015, Radiopharmaceuticals as probes to characterize tumour tissue, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 42, Pages: 537-561, ISSN: 1619-7070

Journal article

AbuAli G, Chaisaklert W, Stelloo E, Pazarentzos E, Hwang M-S, Qize D, Harding SV, Al-Rubaish A, Alzahrani A, Al-Ali A, Sanders TAB, Aboagye EO, Grimm Set al., 2015, The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis, ONCOGENE, Vol: 34, Pages: 1718-1728, ISSN: 0950-9232

Journal article

George GPC, Pisaneschi F, Quang-De N, Aboagye EOet al., 2015, Positron Emission Tomographic Imaging of CXCR4 in Cancer: Challenges and Promises, MOLECULAR IMAGING, Vol: 14, ISSN: 1536-0121

Journal article

Schug ZT, Peck B, Jones DT, Zhang Q, Grosskurth S, Alam IS, Goodwin LM, Smethurst E, Mason S, Blyth K, McGarry L, James D, Shanks E, Kalna G, Saunders RE, Jiang M, Howell M, Lassailly F, Thin MZ, Spencer-Dene B, Stamp G, van den Broek NJF, Mackay G, Bulusu V, Kamphorst JJ, Tardito S, Strachan D, Harris AL, Aboagye EO, Critchlow SE, Wakelam MJO, Schulze A, Gottlieb Eet al., 2015, Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress, CANCER CELL, Vol: 27, Pages: 57-71, ISSN: 1535-6108

Journal article

Udemba A, Smith G, Nguyen Q-D, Kaliszczak M, Carroll L, Fortt R, Fuchter MJ, Aboagye EOet al., 2015, Design, synthesis and initial characterisation of a radiolabelled [F-18]pyrimidoindolone probe for detecting activated caspase-3/7, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 13, Pages: 5418-5423, ISSN: 1477-0520

Journal article

Mura M, Hopkins TG, Michael T, Abd-Latip N, Weir J, Aboagye E, Mauri F, Jameson C, Sturge J, Gabra H, Bushell M, Willis AE, Curry E, Blagden SPet al., 2014, LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression, Oncogene, Vol: 34, Pages: 5025-5036, ISSN: 1476-5594

RNA-binding proteins (RBPs) bind to and post-transcriptionally regulate the stability of mRNAs. La-related protein 1 (LARP1) is a conserved RBP that interacts with poly-A-binding protein and is known to regulate 5′-terminal oligopyrimidine tract (TOP) mRNA translation. Here, we show that LARP1 is complexed to 3000 mRNAs enriched for cancer pathways. A prominent member of the LARP1 interactome is mTOR whose mRNA transcript is stabilized by LARP1. At a functional level, we show that LARP1 promotes cell migration, invasion, anchorage-independent growth and in vivo tumorigenesis. Furthermore, we show that LARP1 expression is elevated in epithelial cancers such as cervical and non-small cell lung cancers, where its expression correlates with disease progression and adverse prognosis, respectively. We therefore conclude that, through the post-transcriptional regulation of genes such as mTOR within cancer pathways, LARP1 contributes to cancer progression.

Journal article

Pazarentzos E, Mahul-Mellier A-L, Datler C, Chaisaklert W, Hwang M-S, Kroon J, Qize D, Osborne F, Al-Rubaish A, Al-Ali A, Mazarakis ND, Aboagye EO, Grimm Set al., 2014, I kappa B alpha inhibits apoptosis at the outer mitochondrial membrane independently of NF-kappa B retention, EMBO JOURNAL, Vol: 33, Pages: 2814-2828, ISSN: 0261-4189

Journal article

Trousil S, Lee P, Pinato DJ, Ellis JK, Dina R, Aboagye EO, Keun HC, Sharma Ret al., 2014, Alterations of Choline Phospholipid Metabolism in Endometrial Cancer Are Caused by Choline Kinase Alpha Overexpression and a Hyperactivated Deacylation Pathway, CANCER RESEARCH, Vol: 74, Pages: 6867-6877, ISSN: 0008-5472

Journal article

Willaime JMY, Aboagye EO, Tsoumpas C, Turkheimer FEet al., 2014, A multifractal approach to space-filling recovery for PET quantification, MEDICAL PHYSICS, Vol: 41, ISSN: 0094-2405

Journal article

Filipovic A, Lombardo Y, Faronato M, Abrahams J, Aboagye E, Quang-De N, d'Aqua BB, Ridley A, Green A, Rahka E, Ellis I, Recchi C, Przulj N, Sarajlic A, Alattia J-R, Fraering P, Deonarain M, Coombes RCet al., 2014, Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells (vol 148, pg 455, 2014), BREAST CANCER RESEARCH AND TREATMENT, Vol: 148, Pages: 463-463, ISSN: 0167-6806

Journal article

Filipovic A, Lombardo Y, Fronato M, Abrahams J, Aboagye E, Quang-De N, d'Aqua BB, Ridley A, Green A, Rahka E, Ellis I, Recchi C, Przulj N, Sarajlic A, Alattia J-R, Fraering P, Deonarain M, Coombes RCet al., 2014, Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells, BREAST CANCER RESEARCH AND TREATMENT, Vol: 148, Pages: 455-462, ISSN: 0167-6806

Journal article

Kenny LM, Aboagye EO, 2014, Clinical Translation of Molecular Imaging Agents Used in PET Studies of Cancer, EMERGING APPLICATIONS OF MOLECULAR IMAGING TO ONCOLOGY, Vol: 124, Pages: 329-374, ISSN: 0065-230X

Journal article

Veronese M, Rizzo G, Aboagye EO, Bertoldo Aet al., 2014, Parametric imaging of F-18-fluoro-3-deoxy-3-L-fluorothymidine PET data to investigate tumour heterogeneity, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 41, Pages: 1781-1792, ISSN: 1619-7070

Journal article

Witney TH, Pisaneschi F, Alam IS, Trousil S, Kaliszczak M, Twyman F, Brickute D, Nguyen Q-D, Schug Z, Gottlieb E, Aboagye EOet al., 2014, Preclinical Evaluation of 3-F-18-Fluoro-2,2-Dimethylpropionic Acid as an Imaging Agent for Tumor Detection, JOURNAL OF NUCLEAR MEDICINE, Vol: 55, Pages: 1506-1512, ISSN: 0161-5505

Journal article

Lavdas I, Miquel ME, McRobbie DW, Aboagye EOet al., 2014, Comparison Between Diffusion-Weighted MRI (DW-MRI) at 1.5 and 3 Tesla: A Phantom Study, JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol: 40, Pages: 682-690, ISSN: 1053-1807

Journal article

Gallo J, Kamaly N, Lavdas I, Stevens E, Nguyen Q, Wylezinska-Arridge M, Aboagye EO, Long NJet al., 2014, CXCR4-Targeted and MMP-Responsive Iron Oxide Nanoparticles for Enhanced Magnetic Resonance Imaging, Angewandte Chemie International Edition, Vol: 53, Pages: 9550-9554, ISSN: 1521-3773

MRI offers high spatial resolution with excellent tissue penetration but it has limited sensitivity and the commonly administered contrast agents lack specificity. In this study, two sets of iron oxide nanoparticles (IONPs) were synthesized that were designed to selectively undergo copper-free click conjugation upon sensing of matrix metalloproteinase (MMP) enzymes, thereby leading to a self-assembled superparamagnetic nanocluster network with T2 signal enhancement properties. For this purpose, IONPs with bioorthogonal azide and alkyne surfaces masked by polyethylene glycol (PEG) layers tethered to CXCR4-targeted peptide ligands were synthesized and characterized. The IONPs were tested in vitro and T2 signal enhancements of around 160 % were measured when the IONPs were incubated with cells expressing MMP2/9 and CXCR4. Simultaneous systemic administration of the bioorthogonal IONPs in tumor-bearing mice demonstrated the signal-enhancing ability of these ‘smart’ self-assembling nanomaterials.

Journal article

Evans HL, Quang-De N, Carroll LS, Kaliszczak M, Twyman FJ, Spivey AC, Aboagye EOet al., 2014, A bioorthogonal Ga-68-labelling strategy for rapid in vivo imaging, CHEMICAL COMMUNICATIONS, Vol: 50, Pages: 9557-9560, ISSN: 1359-7345

Journal article

Kenny LM, Tomasi G, Turkheimer F, Larkin J, Gore M, Brock CS, Mangar S, Aboagye EOet al., 2014, Preliminary clinical assessment of the relationship between tumor alphavbeta3 integrin and perfusion in patients studied with [F-18]fluciclatide kinetics and [O-15]H2O PET, EJNMMI RESEARCH, Vol: 4, ISSN: 2191-219X

Journal article

Alam IS, Witney TH, Tomasi G, Carroll L, Twyman FJ, Quang-De N, Aboagye EOet al., 2014, Radiolabeled RGD Tracer Kinetics Annotates Differential alpha(v)beta(3) Integrin Expression Linked to Cell Intrinsic and Vessel Expression, MOLECULAR IMAGING AND BIOLOGY, Vol: 16, Pages: 558-566, ISSN: 1536-1632

Journal article

Sala R, Quang-De N, Patel CBK, Mann D, Steinke JHG, Vilar R, Aboagye EOet al., 2014, Phosphorylation Status of Thymidine Kinase 1 Following Antiproliferative Drug Treatment Mediates 3 '-Deoxy-3 '-[F-18]-Fluorothymidine Cellular Retention, PLOS ONE, Vol: 9, ISSN: 1932-6203

Journal article

Mapelli P, Tam HH, Sharma R, Aboagye EO, Al-Nahhas Aet al., 2014, Frequency and significance of physiological versus pathological uptake of Ga-68-DOTATATE in the pancreas: validation with morphological imaging, NUCLEAR MEDICINE COMMUNICATIONS, Vol: 35, Pages: 613-619, ISSN: 0143-3636

Journal article

Schelhaas S, Wachsmuth L, Viel T, Honess DJ, Heinzmann K, Smith D-M, Hermann S, Wagner S, Kuhlmann MT, Mueller-Tidow C, Kopka K, Schober O, Schaefers M, Schneider R, Aboagye EO, Griffiths J, Faber C, Jacobs AHet al., 2014, Variability of Proliferation and Diffusion in Different Lung Cancer Models as Measured by 3'-Deoxy-3'-F-18-Fluorothymidine PET and Diffusion-Weighted MR Imaging, JOURNAL OF NUCLEAR MEDICINE, Vol: 55, Pages: 983-988, ISSN: 0161-5505

Journal article

Evans HL, Carroll L, Aboagye EO, Spivey ACet al., 2014, Bioorthogonal chemistry for Ga-68 radiolabelling of DOTA-containing compounds, JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, Vol: 57, Pages: 291-297, ISSN: 0362-4803

Journal article

Trousil S, Hoppmann S, Quang-De N, Kaliszczak M, Tomasi G, Iveson P, Hiscock D, Aboagye EOet al., 2014, Positron Emission Tomography Imaging with F-18-Labeled Z(HER2:2891) Affibody for Detection of HER2 Expression and Pharmacodynamic Response to HER2-Modulating Therapies, CLINICAL CANCER RESEARCH, Vol: 20, Pages: 1632-1643, ISSN: 1078-0432

Journal article

Witney TH, Fortt RR, Aboagye EO, 2014, Preclinical Assessment of Carboplatin Treatment Efficacy in Lung Cancer by F-18-ICMT-11-Positron Emission Tomography, PLOS ONE, Vol: 9, ISSN: 1932-6203

Journal article

Witney TH, Carroll L, Alam IS, Chandrashekran A, Quang-De N, Sala R, Harris R, DeBerardinis RJ, Agarwal R, Aboagye EOet al., 2014, A Novel Radiotracer to Image Glycogen Metabolism in Tumors by Positron Emission Tomography, CANCER RESEARCH, Vol: 74, Pages: 1319-1328, ISSN: 0008-5472

Journal article

Carroll L, Aboagye EO, 2014, A manganese-catalysed oxidative benzylic C-H F-18-fluorination for applications in drug development, JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, Vol: 57, Pages: 181-181, ISSN: 0362-4803

Journal article

Aboagye EO, Aigbirhio FI, Allen P, Arent R, Arrowsmith RL, Banci G, Bagley MC, Bailey CD, Blake T, Bunt AJ, Bushby N, Carroll L, Cons BD, Cortezon F, Dilworth JR, Dorff PN, Eggleston IM, Ellames G, Elmore CS, Ernst G, Estrela P, Faithfull J, Ge H, Geach NJ, Hall J, Harding J, Harwood LM, Hickey MJ, Heys JR, Hogg C, Hudson MJ, James T, Kerr WJ, Killick D, Kingston LP, Kociok-Köhn G, Landvatter S, Lewis F, Lockley WJ, Marken F, Mudd RJ, Pascu SI, Pheko T, Powell ME, Reid M, Riss PJ, Ruhl T, Rustidge DC, Schenk DJ, Schofield C, Schweiger L, Sharma P, Smith D, Tuttle CT, Testa A, Tyson JA, Tyrrell RM, Urbanek R, Wilkinson DJ, Willis CL, Zanda Met al., 2014, Abstracts of the 22nd International Isotope Society (UK Group) Symposium: synthesis and applications of labelled compounds 2013., J Labelled Comp Radiopharm, Vol: 57, Pages: 178-190

Meeting Summary The 22nd annual symposium of the International Isotope Society's United Kingdom Group took place at the Møller Centre, Churchill College, Cambridge, UK, on Friday, 18 October 2013. The meeting was attended by 65 delegates from academia and industry; the life sciences; and chemical, radiochemical and scientific instrument suppliers. Delegates were welcomed by Dr Ken Lawrie (GlaxoSmithKline, UK, chair of the IIS UK group). The subsequent scientific programme consisted of oral and poster presentations on isotopic chemistry and applications of labelled compounds, or of chemistry with potential implications for isotopic synthesis. Both short-lived and long-lived isotopes were represented, as were stable isotopes. The symposium programme was divided into a morning session chaired by Dr Karl Cable (GlaxoSmithKline, UK) and afternoon sessions chaired by Mr Mike Chappelle (Quotient Biosciences, UK) and by Dr Nick Bushby (AstraZeneca, UK). The UK meeting concluded with remarks from Dr Ken Lawrie (GlaxoSmithKline, UK).

Journal article

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