Imperial College London

ProfessorEricAboagye

Faculty of MedicineDepartment of Surgery & Cancer

Professor
 
 
 
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Contact

 

+44 (0)20 3313 3759eric.aboagye

 
 
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Assistant

 

Mrs Maureen Francis +44 (0)20 7594 2793

 
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Location

 

GN1Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

332 results found

Aboagye EO, Smith G, Nguyen QD, Arstad E, Glaser Met al., 2010, WO2010/026388: Isatin derivatives for use as in vivo imaging agents

Patent

Aboagye EO, Aboagye EO, Smith G, 2010, WO2010/023457: Nucleoside analogues useful as positron emission tomography (PET) imaging agents

Patent

Aboagye EO, Vigushin DM, 2010, US2010/0063144: Compounds and uses thereof [HDAC inhibitors]

Patent

Kenny LM, Contractor K, Stebbing J, Al-Nahhas A, Palmieri C, Shousha S, Aboagye EO, Coombes RCet al., 2009, Changes in [F-18]Fluorothymidine Pharmacokinetics Following Capecitabine Treatment in Human Breast Cancer Detected by Positron Emission Tomography, 32nd Annual San Antonio Breast Cancer Symposium, Publisher: AMER ASSOC CANCER RESEARCH, Pages: 765S-765S, ISSN: 0008-5472

Conference paper

Quang-De N, Smith G, Glaser M, Perumal M, Robins E, Aboagye EOet al., 2009, Assessment of tumor response to therapy with the caspase-317 specific [18F]CMT-11 PET imaging tracer, Publisher: AMER ASSOC CANCER RESEARCH, ISSN: 1535-7163

Conference paper

Pardo OE, Latigo J, Jeffery RE, Nye E, Poulsom R, Spencer-Dene B, Lemoine NR, Stamp GW, Aboagye EO, Seckl MJet al., 2009, The Fibroblast Growth Factor Receptor Inhibitor PD173074 Blocks Small Cell Lung Cancer Growth In vitro and In vivo, CANCER RESEARCH, Vol: 69, Pages: 8645-8651, ISSN: 0008-5472

Journal article

Tennant DA, Frezza C, MacKenzie ED, Nguyen QD, Zheng L, Selak MA, Roberts DL, Dive C, Watson DG, Aboagye EO, Gottlieb Eet al., 2009, Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death, ONCOGENE, Vol: 28, Pages: 4009-4021, ISSN: 0950-9232

Journal article

Smith G, Nguyen Q-D, Aboagye EO, 2009, Translational Imaging of Apoptosis, ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, Vol: 9, Pages: 958-967, ISSN: 1871-5206

Journal article

Kenny LM, Contractor KB, Stebbing J, Ai-Nahhas A, Palmieri C, Shousha S, Coombes RC, Aboagye EOet al., 2009, Altered Tissue 3 '-Deoxy-3 '-[F-18]Fluorothymidine Pharmacokinetics in Human Breast Cancer following Capecitabine Treatment Detected by Positron Emission Tomography, CLINICAL CANCER RESEARCH, Vol: 15, Pages: 6649-6657, ISSN: 1078-0432

Journal article

Nguyen Q-D, Smith G, Glaser M, Perumal M, Arstad E, Aboagye EOet al., 2009, Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-3/7 specific [F-18]-labeled isatin sulfonamide, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 16375-16380, ISSN: 0027-8424

Journal article

Contractor KB, Kenny LM, Stebbing J, Al-Nahha A, Palmieri C, Sinnett D, Lewis JS, Hogben K, Osman S, Shousha S, Lowdell C, Coombes RC, Aboagye EOet al., 2009, [C-11]Choline Positron Emission Tomography in Estrogen Receptor-Positive Breast Cancer, CLINICAL CANCER RESEARCH, Vol: 15, Pages: 5503-5510, ISSN: 1078-0432

Journal article

Rosso L, Gray KR, Contractor KB, Kenny LM, Al-Nahhas A, Shousha S, Stebbing J, Wasan HS, Coombes RC, Aboagye EO, Turkheimer FEet al., 2009, New Method for Segmentation of Tumors from [18F] FLT PET Images using Predefined Kinetic Classes, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 36, Pages: S193-S193, ISSN: 1619-7070

Journal article

Rosso L, Brock CS, Gallo JM, Saleem A, Price PM, Turkheimer FE, Aboagye EOet al., 2009, Development of a New Pharmacokinetic Model for the Prediction of Temozolomide Disposition in Gliomas Using Positron Emission Tomography Imaging, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 36, Pages: S270-S271, ISSN: 1619-7070

Journal article

Seckl MJ, Pardo OE, Aboagye EO, Latigo J, Stamp G, Lemoine N, Spencer-Dean Bet al., 2009, The FGF receptor (FGFR) inhibitor PD0173074 blocks SCLC growth in vitro and in vivo, JOURNAL OF THORACIC ONCOLOGY, Vol: 4, Pages: S385-S385, ISSN: 1556-0864

Journal article

Ali S, Heathcote DA, Kroll SHB, Jogalekar AS, Scheiper B, Patel H, Brackow J, Siwicka A, Fuchter MJ, Periyasamy M, Tolhurst RS, Kanneganti SK, Snyder JP, Liotta DC, Aboagye EO, Barrett AGM, Coombes RCet al., 2009, The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity, CANCER RESEARCH, Vol: 69, Pages: 6208-6215, ISSN: 0008-5472

Journal article

Contractor KB, Aboagye EO, 2009, Monitoring Predominantly Cytostatic Treatment Response with F-18-FDG PET, JOURNAL OF NUCLEAR MEDICINE, Vol: 50, Pages: 97S-105S, ISSN: 0161-5505

Journal article

Chapon C, Jackson JS, Aboagye EO, Herlihy AH, Jones WA, Bhakoo KKet al., 2009, An In Vivo Multimodal Imaging Study Using MRI and PET of Stem Cell Transplantation after Myocardial Infarction in Rats, MOLECULAR IMAGING AND BIOLOGY, Vol: 11, Pages: 31-38, ISSN: 1536-1632

Journal article

Rosso L, Brock CS, Gallo JM, Saleem A, Price PM, Turkheimer FE, Aboagye EOet al., 2009, A New Model for Prediction of Drug Distribution in Tumor and Normal Tissues: Pharmacokinetics of Temozolomide in Glioma Patients, CANCER RESEARCH, Vol: 69, Pages: 120-127, ISSN: 0008-5472

Journal article

Julius Leyton, Graham Smith, Yongjun Zhao, Meg Perumal, Quang-De Nguyen, Edward Robins, Erik Arstad, Eric O Aboagyeet al., 2009, [18F]Fluoromethyl-[1,2-2H4]-Choline: A Novel Radiotracer for Imaging Choline Metabolism in Tumors by Positron Emission Tomography, Cancer Research, Vol: 22, Pages: 7721-7728

Journal article

Smith G, Glaser M, Perumal M, Nguyen Q-D, Shan B, Arstad E, Aboagye EOet al., 2008, Design, Synthesis, and Biological Characterization of a Caspase 3/7 Selective Isatin Labeled with 2-[F-18]fluoroethylazide, JOURNAL OF MEDICINAL CHEMISTRY, Vol: 51, Pages: 8057-8067, ISSN: 0022-2623

Journal article

McParland BJ, Miller MP, Spinks TJ, Kenny LM, Osman S, Khela MK, Aboagye E, Coombes RC, Hui AM, Cohen PSet al., 2008, The biodistribution and radiation dosimetry of the Arg-Gly-Asp peptide 18F-AH111585 in healthy volunteers, Journal of Nuclear Medicine, Vol: 49, Pages: 1664-1667

We report the safety, biodistribution, and internal radiation dosimetry of a new PET tracer, (18)F-AH111585, a peptide with a high affinity for the alpha(v)beta(3) integrin receptor involved in angiogenesis. METHODS: PET scans of 8 healthy volunteers were acquired at time points up to 4 h after a bolus injection of (18)F-AH111585. (18)F activity in whole blood and plasma and excreted urine were measured up to 4 h after injection. In vivo (18)F activities in up to 12 source regions were determined from quantitative analysis of the images. The cumulated activities subsequently calculated were then used to determine the internal radiation dosimetry, including the effective dose. RESULTS: Injection of (18)F-AH111585 was well tolerated in all subjects, with no serious or drug-related adverse events reported. The main route of (18)F excretion was renal (37%), and the 3 highest initial uptakes were by liver (15%); combined walls of the small, upper large, and lower large intestines (11%); and kidneys (9%). The 3 highest absorbed doses were received by the urinary bladder wall (124 microGy/MBq), kidneys (102 microGy/MBq), and cardiac wall (59 microGy/MBq). The effective dose was 26 microGy/MBq. CONCLUSION: (18)F-AH111585 is a safe PET tracer with a dosimetry profile comparable to other common (18)F PET tracers.

Journal article

Leyton J, Smith G, Lees M, Perumal M, Nguyen Q-D, Aigbirhio FI, Golovko O, He Q, Workman P, Aboagye EOet al., 2008, Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901, MOLECULAR CANCER THERAPEUTICS, Vol: 7, Pages: 3112-3121, ISSN: 1535-7163

Journal article

Kenny LM, Coombes RC, Oulie I, Contractor KB, Miller M, Spinks TJ, McParland B, Cohen PS, Hui A-M, Palmieri C, Osman S, Glaser M, Turton D, At-Nahhas A, Aboagye EOet al., 2008, Phase I trial of the positron-emitting Arg-Gly-Asp (RGD) peptide radioligand F-18-AH111585 in breast cancer patients, JOURNAL OF NUCLEAR MEDICINE, Vol: 49, Pages: 879-886, ISSN: 0161-5505

Journal article

Pillai RG, Forster M, Perumal M, Mitchell F, Leyton J, Aibgirhio FI, Golovko O, Jackman AL, Aboagye EOet al., 2008, Imaging pharmacodynamics of the alpha-folate receptor-targeted thymidylate synthase inhibitor BGC 945, CANCER RESEARCH, Vol: 68, Pages: 3827-3834, ISSN: 0008-5472

Journal article

Saleem A, Aboagye EO, Matthews JC, Price PMet al., 2008, Plasma pharmacokinetic evaluation of cytotoxic agents radiolabelled with positron emitting radioisotopes, CANCER CHEMOTHERAPY AND PHARMACOLOGY, Vol: 61, Pages: 865-873, ISSN: 0344-5704

Journal article

Aboagye EO, 2008, Design and Development of Probes for In vivo Molecular and Functional Imaging of Cancer and Cancer Therapies by Positron Emission Tomography (PET), Modern Biopharmaceuticals: Design, Development and Optimization, Pages: 1243-1270, ISBN: 9783527311842

Molecular imaging with positron emission tomography (PET) is now evolving as a unique non-invasive method for studying tumor and normal tissue biochemistry, physiology, and pharmacology. In oncology, a range of drugs can be radiolabeled for pharmacokinetic studies including "microdosing" of human subjects prior to Phase I trials. Gene delivery can be assessed by incorporating a reporter gene that is detectable by PET within the vector of interest. This chapter also reviews progress made in the PET imaging field in the design of pharmacodynamic markers including assays of cell surface receptor status, angiogenesis, apoptosis, proliferation, glucose metabolism, and hypoxia. Such probes are potentially useful in patient management and for drug development. PET is particularly attractive for the development of cancer-targeted therapies where assessment of plasma drug levels or assays of the target protein in peripheral blood cells are less specific than direct assessment of the tumor or tumor material. The recent introduction of dedicated small-animal scanners has helped bridge in vitro science with in vivo clinical studies for the efficient development of modern biopharmaceuticals. © 2005 WILEY-VCH Verlag GmbH & Co. KGaA.

Book chapter

Aboagye EO, Vigushin DM, 2008, Compounds and uses thereof [HDAC]

Patent

Leyton J, Aboagye EO, 2007, PET Tracers as biomarkers in oncology drug development, MOLECULAR CANCER THERAPEUTICS, Vol: 6, Pages: 3627S-3628S, ISSN: 1535-7163

Journal article

Chan F, Sun C, Perumal M, Nguyen Q-D, Bavetsias V, McDonald E, Martins V, Wilsher NE, Raynaud FI, Valenti M, Eccles S, te Poele R, Workman P, Aboagye EO, Linardopoulos Set al., 2007, Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity, MOLECULAR CANCER THERAPEUTICS, Vol: 6, Pages: 3147-3157, ISSN: 1535-7163

Journal article

Kenny L, Coombes RC, Vigushin DM, Al-Nahhas A, Shousha S, Aboagye EOet al., 2007, Imaging early changes in proliferation at 1 week post chemotherapy: a pilot study in breast cancer patients with 3 '-deoxy-3 '-[F-18]fluorothymidine positron emission tomography, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 34, Pages: 1339-1347, ISSN: 1619-7070

Journal article

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