Imperial College London

ProfessorEricAboagye

Faculty of MedicineDepartment of Surgery & Cancer

Professor
 
 
 
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Contact

 

+44 (0)20 3313 3759eric.aboagye

 
 
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Assistant

 

Mrs Maureen Francis +44 (0)20 7594 2793

 
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Location

 

GN1Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Leow:2019:10.1109/TUFFC.2019.2906434,
author = {Leow, CH and Bush, N and Stanziola, A and Braga, M and Shah, A and Hernández-Gil, J and Long, NJ and Aboagye, E and Bamber, J and Tang, M},
doi = {10.1109/TUFFC.2019.2906434},
journal = {IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control},
pages = {939--948},
title = {3D microvascular imaging using high frame rate ultrasound and ASAP without contrast agents: development and initial in vivo evaluation on non-tumour and tumour models},
url = {http://dx.doi.org/10.1109/TUFFC.2019.2906434},
volume = {66},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Three-dimensional imaging is valuable to non-invasively assess angiogenesis given the complex 3D architecture of vascular networks. The emergence of high frame rate (HFR) ultrasound, which can produce thousands of images per second, has inspired novel signal processing techniques and their applications in structural and functionalimaging of blood vessels. Although highly sensitive vascular mapping has been demonstrated using ultrafast Doppler, the detectability of microvasculature from the background noise may be hindered by the low signal to noise ratio (SNR) particularly in deeper region and without the use of contrast agents. We have recently demonstrated a coherence based technique, acoustic sub-aperture imaging (ASAP), for super-contrast vascular imaging and illustrated the contrast improvement using HFR contrast-enhanced ultrasound. In this work, we provide a feasibility study for microvascular imaging using ASAP without contrast agents, and extend its capability from 2D to volumetric vascular mapping. Using an ultrasound research system and a pre-clinical probe, we demonstrated the improved visibility of microvascular mapping using ASAP in comparison to ultrafast Power Doppler (PD) on a mouse kidney, liver and tumour without contrast agent injection. The SNR of ASAP images improves in average by 10dB when compared to PD. Besides, directional velocity mappings were also demonstrated by combining ASAP with the phase information extracted from lag-1 autocorrelation. Three-dimensional vascular and velocity mapping of the mouse kidney, liver and tumour were demonstrated by stackingthe ASAP images acquired using 2D ultrasound imaging and a trigger-controlled linear translation stage. The 3D results depicted clear micro-vasculature morphologies and function
AU - Leow,CH
AU - Bush,N
AU - Stanziola,A
AU - Braga,M
AU - Shah,A
AU - Hernández-Gil,J
AU - Long,NJ
AU - Aboagye,E
AU - Bamber,J
AU - Tang,M
DO - 10.1109/TUFFC.2019.2906434
EP - 948
PY - 2019///
SN - 0885-3010
SP - 939
TI - 3D microvascular imaging using high frame rate ultrasound and ASAP without contrast agents: development and initial in vivo evaluation on non-tumour and tumour models
T2 - IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
UR - http://dx.doi.org/10.1109/TUFFC.2019.2906434
UR - http://hdl.handle.net/10044/1/68587
VL - 66
ER -