Imperial College London


Faculty of MedicineDepartment of Surgery & Cancer




+44 (0)20 3313 3759eric.aboagye




Mrs Maureen Francis +44 (0)20 7594 2793




GN1Commonwealth BuildingHammersmith Campus






BibTex format

author = {Leow, CH and Braga, M and Bush, NL and Stanziola, A and Shah, A and Hernández-Gil, J and Long, NJ and Aboagye, EO and Bamber, JC and Tang, MX},
doi = {10.1109/ULTSYM.2018.8579652},
publisher = {IEEE},
title = {Contrast vs non-contrast enhanced microvascular imaging using acoustic sub-aperture processing (ASAP): in vivo demonstration},
url = {},
year = {2019}

RIS format (EndNote, RefMan)

AB - Angiogenesis plays a vital role in the progression of cancer. Non-invasive imaging techniques capable of assessing the microenvironment are therefore of clinical interest. Although highly sensitive vascular mapping has been demonstrated using ultrafast Power Doppler (PD), the detectability of microvasculature from the background noise may be hindered by the low signal-to-noise ratio (SNR) in deeper region and without the use of contrast agents. We recently developed acoustic sub-aperture processing (ASAP) processing for super-contrast vasculature imaging. This technique relies on the spatial coherence of the backscattered echoes over different acquisitions to substantially reduce the noise floor compared to the power Doppler (PD) technique. In this study, we demonstrate the feasibility of applying ASAP processing for non-contrast enhanced microvascular imaging in preclinical condition, and compare it with contrast enhanced ASAP as well as ultrafast PD. Comparing to PD, ASAP exhibit SNR improvement up to 12 dB. Higher SNR and extra visibility of smaller vessel are also demonstrated in contrast enhanced images in comparison to the non-contrast images. In conclusion, we have demonstrated the feasibility of using ASAP in vivo for non-contrast microvascular imaging, and the added benefit of using contrast agents in microvascular imaging.
AU - Leow,CH
AU - Braga,M
AU - Bush,NL
AU - Stanziola,A
AU - Shah,A
AU - Hernández-Gil,J
AU - Long,NJ
AU - Aboagye,EO
AU - Bamber,JC
AU - Tang,MX
DO - 10.1109/ULTSYM.2018.8579652
PY - 2019///
SN - 1948-5719
TI - Contrast vs non-contrast enhanced microvascular imaging using acoustic sub-aperture processing (ASAP): in vivo demonstration
UR -
UR -
ER -