Imperial College London


Faculty of MedicineDepartment of Surgery & Cancer




+44 (0)20 3313 3759eric.aboagye




Mrs Maureen Francis +44 (0)20 7594 2793




GN1Commonwealth BuildingHammersmith Campus






BibTex format

author = {Hernandez-Gil, J and Braga, M and Harriss, B and Carroll, LS and Leow, CH and Tang, M-X and Aboagye, EO and Long, NJ},
doi = {10.1039/c9sc00684b},
journal = {Chemical Science},
pages = {5603--5615},
title = {Development of Ga-68-labelled ultrasound microbubbles for whole-body PET imaging},
url = {},
volume = {10},
year = {2019}

RIS format (EndNote, RefMan)

AB - Microbubble (MB) contrast agents have revolutionalised the way ultrasound (US) imaging can be used clinically and pre-clinically. Contrast-enhanced US offers improvements in soft-tissue contrast, as well as the ability to visualise disease processes at the molecular level. However, its inability to provide in vivo whole-body imaging can hamper the development of new MB formulations. Herein, we describe a fast and efficient method for achieving 68Ga-labelling of MBs after a direct comparison of two different strategies. The optimised approach produces 68Ga-labelled MBs in good yields through the bioorthogonal inverse-electron-demand Diel–Alder reaction between a trans-cyclooctene-modified phospholipid and a new tetrazine-bearing HBED-CC chelator. The ability to noninvasively study the whole-body distribution of 68Ga-labelled MBs was demonstrated in vivo using positron emission tomography (PET). This method could be broadly applicable to other phospholipid-based formulations, providing accessible solutions for in vivo tracking of MBs.
AU - Hernandez-Gil,J
AU - Braga,M
AU - Harriss,B
AU - Carroll,LS
AU - Leow,CH
AU - Tang,M-X
AU - Aboagye,EO
AU - Long,NJ
DO - 10.1039/c9sc00684b
EP - 5615
PY - 2019///
SN - 2041-6520
SP - 5603
TI - Development of Ga-68-labelled ultrasound microbubbles for whole-body PET imaging
T2 - Chemical Science
UR -
UR -
UR -!divAbstract
UR -
VL - 10
ER -