Imperial College London

ProfessorEricAboagye

Faculty of MedicineDepartment of Surgery & Cancer

Professor
 
 
 
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Contact

 

+44 (0)20 3313 3759eric.aboagye

 
 
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Assistant

 

Mrs Maureen Francis +44 (0)20 7594 2793

 
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Location

 

GN1Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ordonez:2020:10.1007/s11307-020-01494-9,
author = {Ordonez, AA and Abhishek, S and Singh, AK and Klunk, MH and Azad, BB and Aboagye, EO and Carroll, L and Jain, SK},
doi = {10.1007/s11307-020-01494-9},
journal = {Molecular Imaging and Biology},
pages = {1--6},
title = {Caspase-based PET for evaluating pro-apoptotic treatments in a tuberculosis mouse model},
url = {http://dx.doi.org/10.1007/s11307-020-01494-9},
year = {2020}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - PurposeDespite recent advances in antimicrobial treatments, tuberculosis (TB) remains a major global health threat. Mycobacterium tuberculosis proliferates in macrophages, preventing apoptosis by inducing anti-apoptotic proteins leading to necrosis of the infected cells. Necrosis then leads to increased tissue destruction, reducing the penetration of antimicrobials and immune cells to the areas where they are needed most. Pro-apoptotic drugs could be used as host-directed therapies in TB to improve antimicrobial treatments and patient outcomes.ProcedureWe evaluated [18F]-ICMT-11, a caspase-3/7-specific positron emission tomography (PET) radiotracer, in macrophage cell cultures and in an animal model of pulmonary TB that closely resembles human disease.ResultsCells infected with M. tuberculosis and treated with cisplatin accumulated [18F]-ICMT-11 at significantly higher levels compared with that of controls, which correlated with levels of caspase-3/7 activity. Infected mice treated with cisplatin with increased caspase-3/7 activity also had a higher [18F]-ICMT-11 PET signal compared with that of untreated infected animals.Conclusions[18F]-ICMT-11 PET could be used as a noninvasive approach to measure intralesional pro-apoptotic responses in situ in pulmonary TB models and support the development of pro-apoptotic host-directed therapies for TB.
AU - Ordonez,AA
AU - Abhishek,S
AU - Singh,AK
AU - Klunk,MH
AU - Azad,BB
AU - Aboagye,EO
AU - Carroll,L
AU - Jain,SK
DO - 10.1007/s11307-020-01494-9
EP - 6
PY - 2020///
SN - 1095-0397
SP - 1
TI - Caspase-based PET for evaluating pro-apoptotic treatments in a tuberculosis mouse model
T2 - Molecular Imaging and Biology
UR - http://dx.doi.org/10.1007/s11307-020-01494-9
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000522584400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://link.springer.com/article/10.1007%2Fs11307-020-01494-9
UR - http://hdl.handle.net/10044/1/81943
ER -