Imperial College London

ProfessorEricAboagye

Faculty of MedicineDepartment of Surgery & Cancer

Professor
 
 
 
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Contact

 

+44 (0)20 3313 3759eric.aboagye

 
 
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Assistant

 

Mrs Maureen Francis +44 (0)20 7594 2793

 
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Location

 

GN1Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cesarec:2020:10.2174/1874471013666200907115026,
author = {Cesarec, S and Robson, JA and Carroll, LS and Aboagye, EO and Spivey, AC},
doi = {10.2174/1874471013666200907115026},
journal = {Curr Radiopharm},
title = {Direct incorporation of [ 18F] into aliphatic systems: A promising Mncatalysed labelling technique for PET imaging.},
url = {http://dx.doi.org/10.2174/1874471013666200907115026},
year = {2020}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - BACKGROUND: One of the challenges in positron emission tomography (PET) is labelling complex aliphatic molecules. OBJECTIVE: To develop a method of metal-catalysed radiofluorination that is site-selective and works in moderate to good yields under facile conditions. METHODS: We report here on the optimisation of an aliphatic C-H to C-18F bond transformation catalysed by a Mn(porphyrin) complex. RESULTS: The successful oxidation of 11 aliphatic molecules including progesterone are reported. Radiochemical Incorporations (RCIs) up to 69% were achieved within 60 min without the need for pre-activation or specialist equipment. CONCLUSION: The method features mild conditions (60 °C) and promises to constitute a valuable approach to labelling of biomolecules and drug substances.
AU - Cesarec,S
AU - Robson,JA
AU - Carroll,LS
AU - Aboagye,EO
AU - Spivey,AC
DO - 10.2174/1874471013666200907115026
PY - 2020///
TI - Direct incorporation of [ 18F] into aliphatic systems: A promising Mncatalysed labelling technique for PET imaging.
T2 - Curr Radiopharm
UR - http://dx.doi.org/10.2174/1874471013666200907115026
UR - https://www.ncbi.nlm.nih.gov/pubmed/32895047
ER -