Imperial College London

ProfessorEricAboagye

Faculty of MedicineDepartment of Surgery & Cancer

Professor
 
 
 
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Contact

 

+44 (0)20 3313 3759eric.aboagye

 
 
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Assistant

 

Mrs Maureen Francis +44 (0)20 7594 2793

 
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Location

 

GN1Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gallo:2013,
author = {Gallo, J and Alam, IS and Lavdas, I and Wylezinska-Arridge, M and Aboagye, EO and Long, NJ and Gallo, J and Alam, IS and Lavdas, I and Wylezinska-Arridge, M and Aboagye, EO and Long, NJ},
journal = {J. Mater. Chem. B},
title = {RGD-targeted MnO nanoparticles as T1 contrast agents for cancer imaging – the effect of PEG length in vivo},
year = {2013}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - As magnetic resonance imaging (MRI) contrast agents, T1 Gd3+ chelates are generally the preferred option for radiologists over T2 iron oxide nanoparticles. The main reason for the popularity of T1 agents is the easier interpretation of T1-weighted MR images. However, the chemical versatility of nanoparticulate platforms makes them ideal candidates for the next generation of targeted MRI contrast agents. In this context, we present herein the design and preparation of a nanoparticulate contrast agent based on MnO, which presents T1 contrast enhancement properties as well as nanoparticle formulation. Functionalization of MnO nanoparticles with the extensively studied RGD peptide was used to target tumours over-expressing the αvβ3 integrin. PEG (polyethylene glycol) molecules were used to increase the blood half-life of the nanoparticles in vivo, and the effect of different PEG lengths on the final contrast on MR images was investigated.
AU - Gallo,J
AU - Alam,IS
AU - Lavdas,I
AU - Wylezinska-Arridge,M
AU - Aboagye,EO
AU - Long,NJ
AU - Gallo,J
AU - Alam,IS
AU - Lavdas,I
AU - Wylezinska-Arridge,M
AU - Aboagye,EO
AU - Long,NJ
PY - 2013///
TI - RGD-targeted MnO nanoparticles as T1 contrast agents for cancer imaging – the effect of PEG length in vivo
T2 - J. Mater. Chem. B
ER -