Imperial College London

ProfessorEricAboagye

Faculty of MedicineDepartment of Surgery & Cancer

Professor
 
 
 
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Contact

 

+44 (0)20 3313 3759eric.aboagye

 
 
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Assistant

 

Mrs Maureen Francis +44 (0)20 7594 2793

 
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Location

 

GN1Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Aboagye:2008:10.1002/9783527620982.ch51,
author = {Aboagye, EO},
booktitle = {Modern Biopharmaceuticals: Design, Development and Optimization},
doi = {10.1002/9783527620982.ch51},
pages = {1243--1270},
title = {Design and Development of Probes for In vivo Molecular and Functional Imaging of Cancer and Cancer Therapies by Positron Emission Tomography (PET)},
url = {http://dx.doi.org/10.1002/9783527620982.ch51},
year = {2008}
}

RIS format (EndNote, RefMan)

TY  - CHAP
AB - Molecular imaging with positron emission tomography (PET) is now evolving as a unique non-invasive method for studying tumor and normal tissue biochemistry, physiology, and pharmacology. In oncology, a range of drugs can be radiolabeled for pharmacokinetic studies including "microdosing" of human subjects prior to Phase I trials. Gene delivery can be assessed by incorporating a reporter gene that is detectable by PET within the vector of interest. This chapter also reviews progress made in the PET imaging field in the design of pharmacodynamic markers including assays of cell surface receptor status, angiogenesis, apoptosis, proliferation, glucose metabolism, and hypoxia. Such probes are potentially useful in patient management and for drug development. PET is particularly attractive for the development of cancer-targeted therapies where assessment of plasma drug levels or assays of the target protein in peripheral blood cells are less specific than direct assessment of the tumor or tumor material. The recent introduction of dedicated small-animal scanners has helped bridge in vitro science with in vivo clinical studies for the efficient development of modern biopharmaceuticals. © 2005 WILEY-VCH Verlag GmbH & Co. KGaA.
AU - Aboagye,EO
DO - 10.1002/9783527620982.ch51
EP - 1270
PY - 2008///
SN - 9783527311842
SP - 1243
TI - Design and Development of Probes for In vivo Molecular and Functional Imaging of Cancer and Cancer Therapies by Positron Emission Tomography (PET)
T1 - Modern Biopharmaceuticals: Design, Development and Optimization
UR - http://dx.doi.org/10.1002/9783527620982.ch51
ER -