Imperial College London
Alternate

ProfessorEricAboagye

Faculty of Medicine, Department of Surgery & Cancer

Professor
 
 
 
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Contact

 

+44 (0)20 3313 3759eric.aboagye

 
 
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Assistant

 

Mrs Maureen Francis +44 (0)20 7594 2793

 
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Location

 

GN1Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Allott:2019:10.1039/c8re00279g,
author = {Allott, L and Barnes, C and Brickute, D and Aboagye, EO},
doi = {10.1039/c8re00279g},
journal = {Reaction Chemistry and Engineering},
pages = {569--574},
title = {An improved automated radiosynthesis of [F-18]FET-beta AG-TOCA},
url = {http://dx.doi.org/10.1039/c8re00279g},
volume = {4},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The fluorine-18 radiolabelled octreotide derivative [18F]FET-βAG-TOCA targeting somatostatin receptor type 2, has been evaluated clinically for positron emission tomography (PET) imaging of neuroendocrine tumours (NETs). We report an improved automated radiosynthesis of [18F]FET-βAG-TOCA with several advantages over the current automated GMP synthesis: 1) cartridge-based purification of 2-[18F]fluoroethylazide ([18F]FEA); 2) simple set-up for the radiolabelling on a single cassette; 3) HPLC purification using a biocompatible mobile phase. [18F]FET-βAG-TOCA was produced with a radiochemical yield of 16.7 ± 0.6% (non-decay corrected) and radiochemical purity ≥98%. The automated synthesis produced multi-patient doses (900 MBq) that were radiochemically stable (≥98%) over 4 hours. In addition, the automated procedure described can be used, with minimal adaptation, to radiolabel any alkyne-containing peptide with [18F]FEA using the GE FASTlab™ platform.
AU  - Allott,L
AU  - Barnes,C
AU  - Brickute,D
AU  - Aboagye,EO
DO  - 10.1039/c8re00279g
EP  - 574
PY  - 2019///
SN  - 2058-9883
SP  - 569
TI  - An improved automated radiosynthesis of [F-18]FET-beta AG-TOCA
T2  - Reaction Chemistry and Engineering
UR  - http://dx.doi.org/10.1039/c8re00279g
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000459805800006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://pubs.rsc.org/en/content/articlelanding/2019/RE/C8RE00279G#!divAbstract
UR  - http://hdl.handle.net/10044/1/72963
VL  - 4
ER  -
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