Imperial College London
Alternate

ProfessorEricAboagye

Faculty of Medicine, Department of Surgery & Cancer

Professor
 
 
 
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Contact

 

+44 (0)20 3313 3759eric.aboagye

 
 
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Assistant

 

Mrs Maureen Francis +44 (0)20 7594 2793

 
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Location

 

GN1Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hernandez-Gil:2019:10.1039/c9sc00684b,
author = {Hernandez-Gil, J and Braga, M and Harriss, B and Carroll, LS and Leow, CH and Tang, M-X and Aboagye, EO and Long, NJ},
doi = {10.1039/c9sc00684b},
journal = {Chemical Science},
pages = {5603--5615},
title = {Development of Ga-68-labelled ultrasound microbubbles for whole-body PET imaging},
url = {http://dx.doi.org/10.1039/c9sc00684b},
volume = {10},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Microbubble (MB) contrast agents have revolutionalised the way ultrasound (US) imaging can be used clinically and pre-clinically. Contrast-enhanced US offers improvements in soft-tissue contrast, as well as the ability to visualise disease processes at the molecular level. However, its inability to provide in vivo whole-body imaging can hamper the development of new MB formulations. Herein, we describe a fast and efficient method for achieving 68Ga-labelling of MBs after a direct comparison of two different strategies. The optimised approach produces 68Ga-labelled MBs in good yields through the bioorthogonal inverse-electron-demand Diel–Alder reaction between a trans-cyclooctene-modified phospholipid and a new tetrazine-bearing HBED-CC chelator. The ability to noninvasively study the whole-body distribution of 68Ga-labelled MBs was demonstrated in vivo using positron emission tomography (PET). This method could be broadly applicable to other phospholipid-based formulations, providing accessible solutions for in vivo tracking of MBs.
AU  - Hernandez-Gil,J
AU  - Braga,M
AU  - Harriss,B
AU  - Carroll,LS
AU  - Leow,CH
AU  - Tang,M-X
AU  - Aboagye,EO
AU  - Long,NJ
DO  - 10.1039/c9sc00684b
EP  - 5615
PY  - 2019///
SN  - 2041-6520
SP  - 5603
TI  - Development of Ga-68-labelled ultrasound microbubbles for whole-body PET imaging
T2  - Chemical Science
UR  - http://dx.doi.org/10.1039/c9sc00684b
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000474412700018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://pubs.rsc.org/en/content/articlelanding/2019/SC/C9SC00684B#!divAbstract
UR  - http://hdl.handle.net/10044/1/72930
VL  - 10
ER  -
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