Imperial College London
Alternate

ProfessorEricAboagye

Faculty of Medicine, Department of Surgery & Cancer

Professor
 
 
 
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Contact

 

+44 (0)20 3313 3759eric.aboagye

 
 
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Assistant

 

Mrs Maureen Francis +44 (0)20 7594 2793

 
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Location

 

GN1Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lu:2021:10.1038/s41416-020-01252-2,
author = {Lu, H and Cunnea, P and Nixon, K and Rinne, N and Aboagye, EO and Fotopoulou, C},
doi = {10.1038/s41416-020-01252-2},
journal = {British Journal of Cancer},
pages = {1286--1293},
title = {Discovery of a biomarker candidate for surgical stratification in high-grade serous ovarian cancer},
url = {http://dx.doi.org/10.1038/s41416-020-01252-2},
volume = {124},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Maximal effort cytoreductive surgery is associated with improved outcomes in advanced high-grade serous ovarian cancer (HGSOC). However, despite complete gross resection (CGR), there is a percentage of patients who will relapse and die early. The aim of this study is to identify potential candidate biomarkers to help personalise surgical radicality.Methods: 136 advanced HGSOC cases who underwent CGR were identified from three public transcriptomic datasets. Candidate prognostic biomarkers were discovered in this cohort by Cox regression analysis, and further validated by targeted RNA-sequencing in HGSOC cases from Imperial College Healthcare NHS Trust (n = 59), and a public dataset. Gene set enrichment analysis was performed to understand the biological significance of the candidate biomarker.Results: We identified ALG5 as a prognostic biomarker for early tumour progression in advanced HGSOC despite CGR (HR = 2.42, 95% CI (1.57–3.75), p < 0.0001). The prognostic value of this new candidate biomarker was additionally confirmed in two independent datasets (HR = 1.60, 95% CI (1.03–2.49), p = 0.0368; HR = 3.08, 95% CI (1.07–8.81), p = 0.0365). Mechanistically, the oxidative phosphorylation was demonstrated as a potential biological pathway of ALG5-high expression in patients with early relapse (p < 0.001).Conclusion: ALG5 has been identified as an independent prognostic biomarker for poor prognosis in advanced HGSOC patients despite CGR. This sets a promising platform for biomarker combinations and further validations towards future personalised surgical care.
AU  - Lu,H
AU  - Cunnea,P
AU  - Nixon,K
AU  - Rinne,N
AU  - Aboagye,EO
AU  - Fotopoulou,C
DO  - 10.1038/s41416-020-01252-2
EP  - 1293
PY  - 2021///
SN  - 0007-0920
SP  - 1286
TI  - Discovery of a biomarker candidate for surgical stratification in high-grade serous ovarian cancer
T2  - British Journal of Cancer
UR  - http://dx.doi.org/10.1038/s41416-020-01252-2
UR  - https://www.nature.com/articles/s41416-020-01252-2
UR  - http://hdl.handle.net/10044/1/86329
VL  - 124
ER  -
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